Browse our ROBO1 Proteins (ROBO1)

Full name:
Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila) Proteins (ROBO1)
On are 9 Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila) (ROBO1) Proteins from 4 different suppliers available. Additionally we are shipping ROBO1 Antibodies (107) and ROBO1 Kits (6) and many more products for this protein. A total of 127 ROBO1 products are currently listed.
AW494633, AW742721, DMT-1, DUTT1, Gm310, MGC122264, ROBO1, roundabout, roundabout-1, SAX3
list all proteins Gene Name GeneID UniProt
ROBO1 24906 O55006
ROBO1 19876 O89026
ROBO1 6091 Q9Y6N7

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ROBO1 Proteins (ROBO1) by Origin

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More Proteins for ROBO1 Interaction Partners

Zebrafish Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila) (ROBO1) interaction partners

  1. These results demonstrate a key role for Robo-Slit signaling in vertebrate longitudinal axon guidance; Robo1 and Robo3 (show ROBO3 Proteins) restricted the extent of defasciculation of the tract of the postoptic commissure.

Mouse (Murine) Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila) (ROBO1) interaction partners

  1. While Slit1 (show SLIT1 Proteins) and Robo2 (show ROBO2 Proteins) are only expressed in peripheral axons and their cell bodies, Slit2 (show SLIT2 Proteins), Slit3 (show SLIT3 Proteins) and Robo1 are also expressed in satellite cells of the dorsal root ganglion, Schwann cells and fibroblasts of peripheral nerves.

  2. restoration of miR (show MLXIP Proteins)-218 inhibited retinal angiogenesis via targeting Robo1. MiR (show MLXIP Proteins)-218 contributed to the inhibition of retinal angiogenesis and miR (show MLXIP Proteins)-218 might be a new therapeutic target for preventing retinal neovascularization..

  3. Robo1-Slit2 interaction required for pathfinding mechanism essential to establish the functionally important habenulo-interpeduncular connection.

  4. FLRT3 (show FLRT3 Proteins) is a Robo1 coreceptor in developing axons.

  5. Slit2 (show SLIT2 Proteins)/Robo1 signaling promotes intestinal tumorigenesis through Src (show SRC Proteins)-mediated activation of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.

  6. Robo1/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice

  7. Roundabout receptor (Robo) genes are expressed in pulmonary neuroendocrine cells (PNECs), a rare, innervated epithelial population. Robo inactivation in mouse lung results in an inability of PNECs to cluster into sensory organoids and triggers increased neuropeptide production upon exposure to air.

  8. Slit2 (show SLIT2 Proteins) signaling through Robo1 and Robo2 (show ROBO2 Proteins) has a role in retinal neovascularization

  9. Data indicate the roles of Slit1 (show SLIT1 Proteins)/Robo1 and Netrin1/DCC (show DCC Proteins) signals in positioning motor neuron cell bodies.

  10. This study demonistrated that significant increase of interneurons in the cortices of Robo1-/- mice, implicate Robo1 in the regulation of progenitor cell dynamics in the developing forebrain.

Human Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila) (ROBO1) interaction partners

  1. ROBO1 gene mutation is responsible for the development of pituitary stalk interruption syndrome.

  2. human placental multipotent mesenchymal stromal cell express Slit2 (show SLIT3 Proteins) and both Robo1 and Robo4 (show ROBO4 Proteins) are present in human umbilical vein endothelial cells.

  3. Slit2 (show SLIT3 Proteins)-Robo1 signaling promoted the adhesion, invasion and migration of tongue carcinoma cells by upregulating the expression levels of MMP2 (show MMP2 Proteins) and MMP9 (show MMP9 Proteins) and, downregulating the expression of E-cadherin (show CDH1 Proteins).

  4. High Slit2 expression is associated with glioma.

  5. ROBO1 mediated the inhibitory effect of miR (show MLXIP Proteins)-218 on angiogenesis in gastric cancer.

  6. Results indicate the importance of SLIT2 (show SLIT3 Proteins)-ROBO1-CDC42 (show CDC42 Proteins) signaling pathway in predicting tumor progression.

  7. We postulate that Robo1 promotes tumor invasion partly by the upregulation of MMP2 (show MMP2 Proteins) after activation of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway. Notably, Slit2 (show SLIT3 Proteins) knockdown caused the upregulation of Robo1 expression both at the mRNA and protein levels. Thus, the stimulatory effects of Slit2 (show SLIT3 Proteins) knockdown on tumor progression can be ascribed, at least in part, to the upregulation of Robo1 and its positive role in tumor progression.

  8. ROBO1 deletion in a putative transcriptional regulatory region

  9. Over-expression of miR (show MLXIP Proteins)-218 in glioma cells may inhibit the proliferation and tumorigenicity through targeting Robo1, suggesting that miR (show MLXIP Proteins)-218 could be a potential target for developing therapies in treating glioma.

  10. Significantly increased serum Slit2 (show SLIT3 Proteins) levels and hepatic expression of Slit2 (show SLIT3 Proteins) and Robo1 were observed in patients with liver fibrosis.

ROBO1 Protein Profile

Protein Summary

Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with ROBO1

  • roundabout homolog 1 (robo1)
  • roundabout, axon guidance receptor, homolog 1 (Drosophila) (ROBO1)
  • roundabout, axon guidance receptor, homolog 1 (robo1)
  • roundabout, axon guidance receptor, homolog 1 (Drosophila) (robo1)
  • RoBo-1 (LOC24906)
  • roundabout homolog 1 (Drosophila) (Robo1)
  • roundabout, axon guidance receptor, homolog 1 (Drosophila) (Robo1)
  • AW494633 protein
  • AW742721 protein
  • DMT-1 protein
  • DUTT1 protein
  • Gm310 protein
  • MGC122264 protein
  • ROBO1 protein
  • roundabout protein
  • roundabout-1 protein
  • SAX3 protein

Protein level used designations for ROBO1

roundabout (axon guidance receptor, Drosophila) homolog 1 , roundabout, axon guidance receptor, homolog 1 (Drosophila) , Roundabout1 protein , roundabout-1 , roundabout 1 , roundabout homolog 1 , roundabout, axon guidance receptor, homolog 1 , roundabout homolog 1-like , divalent metal transporter-1 , protein RoBo-1 , rodent bone protein , deleted in U twenty twenty

30769 Danio rerio
395292 Gallus gallus
399392 Xenopus laevis
460518 Pan troglodytes
536815 Bos taurus
722879 Macaca mulatta
100027473 Monodelphis domestica
100069075 Equus caballus
100124716 Xenopus (Silurana) tropicalis
100344245 Oryctolagus cuniculus
100387812 Callithrix jacchus
100459973 Pongo abelii
100517310 Sus scrofa
100545249 Meleagris gallopavo
100559253 Anolis carolinensis
100595092 Nomascus leucogenys
24906 Rattus norvegicus
19876 Mus musculus
6091 Homo sapiens
58946 Rattus norvegicus
487690 Canis lupus familiaris
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