Browse our Ribonucleotide Reductase M1 Proteins (RRM1)

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Ribonucleotide Reductase M1 Proteins (RRM1)
On www.antibodies-online.com are 19 Ribonucleotide Reductase M1 (RRM1) Proteins from 6 different suppliers available. Additionally we are shipping Ribonucleotide Reductase M1 Antibodies (116) and Ribonucleotide Reductase M1 Kits (14) and many more products for this protein. A total of 153 Ribonucleotide Reductase M1 products are currently listed.
Synonyms:
cb396, cb838, CG5371, CHUNP6866, Dmel\\CG5371, DmRNR1, l(2)k06709, r1, RIR1, RNR1, RnrM1, RntL, RR1, sb:cb548, wu:fb39b07, wu:fi14b02, wu:fk95f07, XRRM1
list all proteins Gene Name GeneID UniProt
RRM1 6240 P23921
RRM1 20133 P07742
Rat RRM1 RRM1 685579  

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Ribonucleotide Reductase M1 Proteins (RRM1) by Origin

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More Proteins for Ribonucleotide Reductase M1 Interaction Partners

Human Ribonucleotide Reductase M1 (RRM1) interaction partners

  1. findings suggest that the up-regulated RRM1 and hTrx1 (show MLL Proteins) in colorectal cancer directly interact with each other and promote RR activity, resulting in enhanced DNA synthesis and cancer malignancy.

  2. RRM1 and ERCC1 (show ERCC1 Proteins) expression levels did not show any relationship with overall survival.

  3. RRM1 and ERCC wild type alleles are risk-reducing factor for Coronary artery disease (CAD). Also, carrying RRM1 A allele might have a protective effect for smokers.

  4. Presence of rare AA (-37C>A) and CC (-524C>T) genotypes of the RRM1 may be favorable predictive factors for chemotherapy with platinum compounds and gemcitabine in non-small cell lung cancer patients.

  5. study finds that ERCC1 (show ERCC1 Proteins) and RRM1 are not independent prognostic factors of recurrence in stage I non-small cell lung cancer patients

  6. mRNA expression of RRM1 was closely associated with cell proliferation and varied in seven non-Hodgkin lymphoma cell lines.

  7. A significant association has been found between RRM1 rs12806698 (-269C>A) RRM1 genotype and the risk for developing non-small cell lung cancer.

  8. Results underline the relevance of microRNA-101-3p-driven regulation of RRM1 in pancreatic ductal carcinoma gemcitabine resistance.

  9. TUBB3 (show TUBB3 Proteins), TOP2A (show TOP2A Proteins), CYP19A1 (show CYP19A1 Proteins) and CYP2D6 (show CYP2D6 Proteins) gene expression, but not protein expression, was associated with patient survival.

  10. A possible predictive impact of ribonucleotide-reductase subunit-1 (RRM1) on vinorelbine efficacy in non-small cell lung cancer (NSCLC) has been previously reported.

Mouse (Murine) Ribonucleotide Reductase M1 (RRM1) interaction partners

  1. This study provides an improved understanding of the molecular basis (structure and dynamics) that governs the binding of the p54(nrb)/NonO (show NONO Proteins) RRM1 to one of its target RNAs.

  2. This work reveals that binding of RRM1 to RRM2 (show RRM2 Proteins) is essential for mammalian cells and provides the first loss-of-function model of the ribonucleotide reductase complex for genetic studies.

  3. analysis of transgenic overexpression of ribonucleotide reductase Rrm1 and Rrm2 (show RRM2 Proteins) improves cardiac performance

  4. silencing RRM1 expression using siRNA could potentially be an effective strategy to overcome gemcitabine resistance.

  5. Tip60 (show KAT5 Proteins)-dependent recruitment of RNR plays an essential role in dNTP supply for DNA repair

  6. The hexamer form of murine ribonucleotide reductase (mRR) large catalytic subunit mR1 (show MR1 Proteins)(6) predominates over the dimer form mR1 (show MR1 Proteins)(2) in the cytoplasm of normal cells, where the great majority of mRR activity is located.

  7. overexpression of RRM1 in human and mouse lung cancer cell lines induced PTEN expression, reduced phosphorylation of focal adhesion kinase (FAK), suppressed migration, invasion, and metastasis formation, and increased survival in an animal model.

Ribonucleotide Reductase M1 (RRM1) Protein Profile

Protein Summary

This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.

Alternative names and synonyms associated with Ribonucleotide Reductase M1 (RRM1)

  • ribonucleotide reductase M1 (RRM1)
  • Ribonucleoside diphosphate reductase large subunit (RnrL)
  • ribonucleotide reductase M1 (rrm1)
  • ribonucleotide reductase M1 (Rrm1)
  • ribonucleotide reductase M1 polypeptide (rrm1)
  • cb396 protein
  • cb838 protein
  • CG5371 protein
  • CHUNP6866 protein
  • Dmel\\CG5371 protein
  • DmRNR1 protein
  • l(2)k06709 protein
  • r1 protein
  • RIR1 protein
  • RNR1 protein
  • RnrM1 protein
  • RntL protein
  • RR1 protein
  • sb:cb548 protein
  • wu:fb39b07 protein
  • wu:fi14b02 protein
  • wu:fk95f07 protein
  • XRRM1 protein

Protein level used designations for RRM1

ribonucleoside diphosphate reductase large subunit , CG5371-PA , RnrL-PA , ribonucleoside diphosphate reductase M1 subunit , ribonucleoside-diphosphate reductase large subunit , ribonucleoside-diphosphate reductase M1 chain , ribonucleotide reductase M1 polypeptide , ribonucleotide reductase M1 , ribonucleoside-diphosphate reductase large subunit-like , ribonucleoside-diphosphate reductase subunit M1 , ribonucleotide reductase, R1 subunit , ribonucleotide reductase large subunit , ribonucleotide reductase protein r1 class I

GENE ID SPECIES
100053126 Equus caballus
34392 Drosophila melanogaster
450974 Pan troglodytes
717990 Macaca mulatta
100472317 Ailuropoda melanoleuca
100562780 Anolis carolinensis
100599741 Nomascus leucogenys
399431 Xenopus laevis
419081 Gallus gallus
6240 Homo sapiens
476823 Canis lupus familiaris
505537 Bos taurus
20133 Mus musculus
685579 Rattus norvegicus
100525117 Sus scrofa
100172956 Pongo abelii
30740 Danio rerio
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