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SIVA1, Apoptosis-Inducing Factor Proteins (SIVA1)
On are 15 SIVA1, Apoptosis-Inducing Factor (SIVA1) Proteins from 6 different suppliers available. Additionally we are shipping SIVA1 Antibodies (43) and SIVA1 Kits (11) and many more products for this protein. A total of 75 SIVA1 products are currently listed.
CD27bp, Siva, Siva-1, Siva-2
list all proteins Gene Name GeneID UniProt
SIVA1 10572 O15304
SIVA1 30954 O54926
SIVA1 362791  

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Human SIVA1, Apoptosis-Inducing Factor (SIVA1) interaction partners

  1. Loss of SIVA1 expression is associated with nasopharyngeal carcinoma.

  2. These findings collectively reveal a novel role for the p53 (show TP53 Proteins) target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53 (show TP53 Proteins).

  3. Functional test demonstrated that Siva1 significantly inhibited the invasion and migration of HCT116 cells.

  4. electrical stimulation -inducible SIVA1 modulates p53 (show TP53 Proteins) activities in proliferating keratinocytes, and exogenous electrical stimulation affects p53 (show TP53 Proteins)/HDM2/SIVA1 axis leading to increased proliferation during re-epithelialization

  5. SIVA1 interacts with RAD18 (show RAD18 Proteins) and serves as a molecular bridge between RAD18 (show RAD18 Proteins) and PCNA (show PCNA Proteins), thus targeting the E3 ligase activity of RAD18 (show RAD18 Proteins) onto PCNA (show PCNA Proteins).

  6. Siva1 promotes the ubiquitination and degradation of ARF, which in turn affects the stability of p53 (show TP53 Proteins).

  7. Upon stimulation of thromboxane A2, degradation of Siva1 is impeded, resulting in an accumulation of the protein, which translocates from the nucleus to the cytosol.

  8. negative regulator of IL-2 gene expression in Treg cells

  9. Data show that low levels of Siva1 and Ser16-phosphorylated stathmin (show STMN1 Proteins) correlate with high metastatic states of breast cancer cells.

  10. These findings suggest that the caspase (show CASP3 Proteins)-dependent pathway for induction of apoptosis is involved in Siva-1-mediated influenza A virus replication.

Mouse (Murine) SIVA1, Apoptosis-Inducing Factor (SIVA1) interaction partners

  1. These findings collectively reveal a novel role for the p53 (show TP53 Proteins) target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53 (show TP53 Proteins).

  2. Data indicate that p53 (show TP53 Proteins) target Siva is pivotal in regulating apoptosis in the pathology of renal ischemia reperfusion injury.

  3. SIVA is a direct transcriptional target for the tumor suppressors p53 (show TP53 Proteins) and E2F1 (show E2F1 Proteins)

  4. Siva's expression pattern suggests that it plays an instructive role in apoptosis, and accordingly, we demonstrate that Siva is essential for p53 (show TP53 Proteins)-dependent apoptosis in cerebellar granule neurons.

  5. lysophosphatidic acid 2 (show PTOV1 Proteins) receptor mediates down-regulation of Siva-1 to promote cell survival

  6. Data show that SLIMMER (show FHL1 Proteins) delayed Siva-1-dependent apoptosis in C2C12 myoblasts.

SIVA1 Protein Profile

Protein Summary

This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.

Alternative names and synonyms associated with SIVA1

  • SIVA1, apoptosis-inducing factor (SIVA1)
  • SIVA1, apoptosis-inducing factor (Siva1)
  • CD27bp protein
  • Siva protein
  • Siva-1 protein
  • Siva-2 protein

Protein level used designations for SIVA1

CD27-binding (Siva) protein , apoptosis regulatory protein Siva , CD27-binding protein , Cd27 binding protein , CD27BP

10572 Homo sapiens
30954 Mus musculus
362791 Rattus norvegicus
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