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Overexpression of miR (show MLXIP ELISA Kits)-935 inhibited SOX7 expression.
The results suggest that miR (show MLXIP ELISA Kits)-664 functions as an oncogene (show RAB1A ELISA Kits) miRNA and has an important role in promoting human osteosarcoma cell invasion and migration by suppressing SOX7 expression.
miR (show MLXIP ELISA Kits)-595 played a critical role in carcinogenesis by suppression of SOX7.
Aberrant methylation of the promoter regions of the SOX7 gene in patients with acute myeloid leukemias.
miR (show MLXIP ELISA Kits)-935 contributed to cell proliferation of gastric cancer through targeting SOX7.
the HMG (show SSRP1 ELISA Kits)-box is a key domain of SOX7 for negatively regulating the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway when functioning as a tumor suppressor in a glioma.
The results provided unequivocal evidence for a novel tumor suppressor role of SOX7 in acute myeloid leukemia (show BCL11A ELISA Kits)
SOX7 plays an important inhibitory role in hepatocarcinogenesis, and might be a novel target for hepatocellular carcinoma therapy.
Ectopic expression of miR (show MLXIP ELISA Kits)-492 led to downregulation of SOX7 protein.
Low SOX7 expression is associated with hepatocellular carcinoma.
SOX7 mRNA is localized to the vegetal region of the blastula-stage embryo
SOX7 and SOX18b are essential regulators of cardiogenesis in Xenopus.
Vegetal pole localized Sox7 positively regulates Nodal (Xnr4, Xnr5, and Xnr6) expression, as well as the expression of genes involved in mesodermal (Xmenf, Slug, and Snail) and endodermal (Endodermin and Sox17beta) differentiation.
SOX7 inhibits the expression of RUNX1 (show RUNX1 ELISA Kits) target genes in hemogenic endothelium, while having no effect on RUNX1 (show RUNX1 ELISA Kits) expression itself. SOX7 directly interacts with RUNX1 (show RUNX1 ELISA Kits) and inhibits its transcriptional activity.
Dynamically and epigenetically coordinated GATA2 (show GATA2 ELISA Kits)/ETS1SOX7 transcription factor expression is indispensable for endothelial cell differentiation.
combined deletion of Sox7, Sox17 (show SOX17 ELISA Kits), and Sox18 (show SOX18 ELISA Kits) at the onset of retinal angiogenesis leads to a dense capillary plexus with a nearly complete loss of radial arteries and veins, whereas the presence of a single Sox17 (show SOX17 ELISA Kits) allele largely restores arterial identity
These data indicate that Sox7 is dispensable for both differentiation and maturation of primitive endoderm in an mouse embryonic stem cell model system.
ETV2 directly regulates Sox7, and ETV2 governs endothelial development by regulating transcriptional networks which include Sox7.
Notch and SoxF factors combinatorially regulate Dll4 expression in arteries downstream of VEGF.
Haploinsufficiency of Sox7 or Gata4 (show GATA4 ELISA Kits) is sufficient to produce anterior congenital diaphragmatic hernia in mice.
SOX7 regulates the expression of VE-cadherin (show CDH5 ELISA Kits) in the haemogenic endothelium at the onset of haematopoietic development.
Sox7-sustained expression in the earliest committed hematopoietic precursors promotes the maintenance of their multipotent and self-renewing status.
SOX7 and GATA-4 (show GATA4 ELISA Kits) are competitive activators of Fgf-3 (show FGF3 ELISA Kits) transcription
Sox7 levels are crucial in arterial specification in conjunction with hey2 (show HEY2 ELISA Kits) and efnb2 (show EFNB2 ELISA Kits) function, with mutants in all three genes displaying shunt formation and an arterial block.
Sox7/18 factors and Notch (show NOTCH1 ELISA Kits) regulate nr2f2 (show NR2F2 ELISA Kits) gene expression during venous differentiation in zebrafish.
Sox7 and Sox18 (show SOX18 ELISA Kits)-mediated transcriptional regulation of Robo4 (show ROBO4 ELISA Kits) is important in the developing embryonic vasculature
Sox7 and sox18 (show SOX18 ELISA Kits) are specifically expressed in the developing vasculature, and simultaneous loss of their function results in a severe loss of the arterial identity of the presumptive aorta.
Sox7 and sox18 (show SOX18 ELISA Kits) play redundant but collectively essential roles in the establishment of proper arteriovenous identity in zebrafish.
Sox7 and Sox18 (show SOX18 ELISA Kits) control arterial-venous identity by regulating Gridlock (show HEY2 ELISA Kits) expression.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway.
transcription factor SOX-7
, SRY-box containing gene 7
, SRY (sex determining region Y)-box 7, xSox7 protein
, transcription factor Sox-7
, SRY (sex determining region Y)-box 7