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We demonstrate that MHCII is dispensable for the B cell phenotype of (signal peptide peptidase-like 2a) SPPL2a(-/-) mice, further supporting a CD74-intrinsic effect.
MIF (show MIF ELISA Kits)-CD74 signaling inhibits interferon (IFN)-gamma (show IFNA ELISA Kits) secretion in microglia through phosphorylation of microglial ERK1/2 (show MAPK1/3 ELISA Kits) (extracellular signal-regulated protein kinases 1 and 2). The inhibition of MIF (show MIF ELISA Kits) signaling or its receptor CD74 promotes IFN-gamma (show IFNG ELISA Kits) release and amplifies tumor death either through pharmacological inhibition or through siRNA-mediated knockdown.
CD74-knockout mice showed disturbed placental morphology, reduced junctional zone, smaller placentas, and impaired spiral artery remodeling with fetal growth restriction.
explored CD74 expression, which can form a complex with CD44 (show CD44 ELISA Kits), in glomerular parietal epithelial cells during the progression of a model of focal segmental glomerulosclerosis
Data show that cathepsins S (CatS) regulates CCL2 (show CCL2 ELISA Kits) chemokine (show CCL1 ELISA Kits) expression by modulation of CD74 antigen processing.
Suggest that the DQA1*0103/CD74 dimer may result in presentation of unique antigens and susceptibility to develop arthritis.
CD74 plays a critical role in the MIF (show MIF ELISA Kits) inhibition of osteoclastogenesis.
Genetic deletion of CD74 restored the ability of infected dendritic cells to present a parasite antigen in the context of MHC-II.
SPPL2a-mediated processing of CD74 NTF (show TNF ELISA Kits) is indispensable to maintain appropriate levels of tonic BCR (show BCR ELISA Kits) signaling to promote B cell maturation (show TNFRSF17 ELISA Kits).
Results support the hypothesis that neurodegeneration following traumatic brain injury is dependent upon antigen processing and presentation that requires CD74
these observations are consistent with the view that CD74 expression in tumor cells promotes the intratumoral immune response and is associated with a better prognosis in basal-like breast cancer
MIF (show AMH ELISA Kits)-CD74 signaling inhibits interferon (IFN)-gamma (show IFNA ELISA Kits) secretion in microglia through phosphorylation of microglial ERK1/2 (show MAPK1/3 ELISA Kits) (extracellular signal-regulated protein kinases 1 and 2). The inhibition of MIF (show AMH ELISA Kits) signaling or its receptor CD74 promotes IFN-gamma (show IFNG ELISA Kits) release and amplifies tumor death either through pharmacological inhibition or through siRNA-mediated knockdown.
High CD74 expression is associated with colorectal cancer.
the roles of CD74 and MIF (show AMH ELISA Kits) in the immune surveillance escape process
CD74 downregulation in placental macrophages is present in preeclampsia.
CD74 was increased in burn patients.
predicted binding of one CD74 trimer to a single RTL1000 antagonist utilized the same two 5 residue determinants
an inverse correlation with the tumor size for stromal MIF (show AMH ELISA Kits) and a positive correlation with the triple receptor negative tumor status for stromal CD74 seem to be showed
Studies indicate that the invariant chain (CD74) is critical for antigen presentation.
FOXP1 (show FOXP1 ELISA Kits) represents a novel regulator of genes targeted by the class II MHC (show HLAE ELISA Kits) transactivator CIITA (show CIITA ELISA Kits) and CD74.
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
H-2 class II histocompatibility antigen gamma chain
, Ia-associated invariant chain
, MHC class II-associated invariant chain
, class II-associated invariant chain peptide
, dinucleotide microsatellite
, histocompatibility: class II antigens, gamma chain of
, ia antigen-associated invariant chain
, invariant polypeptide of major histocompatibility complex, class II antigen-associated
, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
, HLA class II histocompatibility antigen gamma chain
, HLA-DR antigens-associated invariant chain
, MHC HLA-DR gamma chain
, gamma chain of class II antigens