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anti-Human Dopamine d2 Receptor Antibodies:
anti-Rat (Rattus) Dopamine d2 Receptor Antibodies:
anti-Mouse (Murine) Dopamine d2 Receptor Antibodies:
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Human Polyclonal Dopamine d2 Receptor Primary Antibody for IF (p), IHC (p) - ABIN730858
Xu, Wang, Chen, Chen, Li, Shao, Li, Lu, Zhou: Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells. in Acta pharmacologica Sinica 2014
Show all 6 Pubmed References
Human Polyclonal Dopamine d2 Receptor Primary Antibody for IHC (p) - ABIN4305945
Srirajaskanthan, Watkins, Marelli, Khan, Caplin: Expression of somatostatin and dopamine 2 receptors in neuroendocrine tumours and the potential role for new biotherapies. in Neuroendocrinology 2009
Show all 2 Pubmed References
Human Monoclonal Dopamine d2 Receptor Primary Antibody for ELISA, WB - ABIN515070
Akimoto, Furuse: SCH23390, a dopamine D1 receptor antagonist, suppressed scratching behavior induced by compound 48/80 in mice. in European journal of pharmacology 2011
Bat Polyclonal Dopamine d2 Receptor Primary Antibody for IHC (p) - ABIN4305946
Saveanu, Sebag, Guillet, Archange, Essamet, Barlier, Palazzo, Taïeb: Targeting dopamine receptors subtype 2 (D2DR) in pheochromocytomas: head-to-head comparison between in vitro and in vivo findings. in The Journal of clinical endocrinology and metabolism 2013
Findings suggest a role for dopamine D1-like receptor (show DRD1 Antibodies) Dop1R2 in the repression of genes that coordinate metamorphosis.
Results suggest that the activation state of DAMB protein contributes to oxidative stress susceptibility in Drosophila and lead to a proposed model for paraquat neurotoxicity.
Mapped associations occur between changes in D2 and D3 dopamine receptor (show DRD3 Antibodies) occupancy and brain hemodynamics
These data provide evidence for a predisposition to self-administer cocaine based on dopamine D2 receptor availability, and demonstrate that the brain dopamine system responds rapidly following cocaine exposure.
The amount of dopamine d1 receptor (show DRD1 Antibodies), dopamine D2 receptor, and follicle stimulating hormone receptor (show FSHR Antibodies) mRNA were quantified in ovarian tissues in anestrous and mares expressing estrus during the breeding season are reported.
The pig DRD2 gene was cloned, investigated its distribution in tissues and polymorphisms were identified.
The increase in NOS (show NOS Antibodies) protein seen in both the endothelium and vascular smooth muscle in response to cerebral vasospasm is enhanced by dopamine in a D(2)R-dependent mechanism.
Lowering the level of cellular FLNA (show FLNA Antibodies) caused an elevation in RalA (show rala Antibodies) activity and resulted in selective interference with the normal intracellular trafficking and signaling of D2R through GRK2 (show ADRBK1 Antibodies). Knockdown of FLNA (show FLNA Antibodies) or coexpression of active RalA (show rala Antibodies) interfered with the recycling of the internalized D2R and resulted in the development of receptor tolerance. Active RalA (show rala Antibodies) was found to interact with GRK2 (show ADRBK1 Antibodies) to sequester it from D2R.
Using the human glycosylated native conformational D2R, study shows the importance of D2R extracellular N-terminus in regulating receptor availability at the cell surface, human anti-D2R antibody binding, and potential pathogenic mechanisms of these antibodies.
this study shows that D3R is palmitoylated more extensively than D2R even though the carboxyl terminus tails of D2R and D3R are highly homologous, and thus provides a new clue regarding the consensus sequence for palmitoylation.
High frequencies of the DRD2/ANKK1 (show ANKK1 Antibodies) A1 allele were present in Mexican populations
rs1076560(T) imparts a small but reliable risk for schizophrenia. and was associated with impaired verbal fluency and comprehension in schizophrenia. It was associated with impaired verbal fluency and comprehension in schizophrenia, and disrupted a binding site for the splicing factor ZRANB2. This work implicates rs1076560(T) as one possible risk factor for schizophrenia in the Han Chinese population.
A combined haplotype (9R-A2) of DAT-1 (show SLC6A3 Antibodies) and DRD2 genes was associated with the murderer phenotype among Pakistani violent criminal inmates.
The Parkinson's disease-associated LRRK2 (show LRRK2 Antibodies) mutant G2019S impairs DRD1 (show DRD1 Antibodies) internalization, leading to an alteration in signal transduction. The mutant forms of LRRK2 (show LRRK2 Antibodies) also affect receptor turnover by decreasing the rate of DRD2 trafficking from the Golgi complex to the cell membrane.
Methylation levels of the DRD2 gene were elevated in patients with Tourette syndrome compared to normal controls. In addition, we found an association between DNA methylation (show HELLS Antibodies) and tic (show ARNTL Antibodies) severity with higher methylation of DRD2, but lower methylation of DAT (show SLC6A3 Antibodies) in more severely affected patients.
These results disclosed a previously uncharacterized role of TSPAN7 (show TSPAN7 Antibodies) in the regulation of the expression and functional activity of DRD2 by postendocytic trafficking.
Findings suggest that subcortical dopamine function may contribute to negative symptom severity and self-reported anhedonia, independent of diagnostic status, in schizophrenia or schizoaffective disorder; dorsal striatal D2R binding correlated with clinician-rated and self-reported negative symptom severity
The expression of Klf15 is increased during neuropathic pain. TNF-alpha regulates the expression of Klf15. KLF15 regulates the expression of dopamine D2 receptor. KLF15 regulates neuropathic pain in mouse models.
MIce that selectively lack dopamine type 2 receptors (D2Rs) from pituitary lactotropes have chronic high prolactin (show PRL Antibodies) levels associated with increased body weight, marked increments in fat depots, adipocyte size, and serum lipids, and a metabolic phenotype.
Data show that the fine control of excitatory transmission by glycogen synthase kinase 3 (show GSK3a Antibodies) requires recruitment of dopamine D2-receptors and depends on the presence of serotonin 5-HT1A (show HTR1A Antibodies)-receptors.
Study found no differences in the D2R binding following ten-day methamphetamine administration and seven-day withdrawal, possibly suggesting that alterations in the D2R are not involved in the emergence of anxiety-related symptoms and the development of psychomotor sensitization during withdrawal
Results suggest that the role of reduced D2 receptor in obesity lies not in increasing appetitive motivation and generating compulsive eating but rather in altering activity and energy expenditure, favoring reduced behavioral expenditure of energy. More broadly, these data are consistent with a fundamental role for dopamine in regulating behavioral energy expenditure.
D2R agonist treatment blocks tumor growth, induces regression of the aberrant blood supply and normalizes blood vessels. An anti-Vegf therapy is also effective to restrain tumor growth and improves vascular remodeling. Importantly, only the combination treatment suppresses intratumoral hemorrhage and restores blood vessel perfusion, suggesting that it might represent an attractive therapy targeting tumor vasculature
Data indicate a contribution of D2 dopamine receptors to the effects of repetitive transcranial magnetic stimulation (rTMS) on postsynaptic density protein-95 (PSD-95 (show DLG4 Antibodies)) and cyclin-dependent kinase 5 (CDK5 (show CDK5 Antibodies)) levels.
These results suggest that DRD2 activation is involved in alleviation of CIA (show NCOA5 Antibodies) symptoms by amelioration of Th17/Treg imbalance.
Study demonstrated that chronic social defeat stress induced increased expression of DRD2 dimers in the prefrontal cortex of susceptible and/or unsusceptible mice
Studied a novel Dopamine Receptor 2 (DRD2) G/A SNP for resistance to fescue toxicosis.
Dopamine D2 receptor play role in memory consolidation.
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia\; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.
, D[]-like receptor
, dopamine receptor 2
, dopamine receptor in mushroom bodies
, dopamine-2 receptor
, D(2) dopamine receptor
, D2 dopamine receptor
, Dopamine D2 receptor
, dopamine receptor D2b
, dopamine D2 receptor 1
, dopamine D2 receptor 2
, D(2) dopamine receptor A
, D2R 1
, dopamine receptor D2
, dopamine D2 receptor
, dopamine receptor D2 isoform
, seven transmembrane helix receptor
, D2 receptor
, dopamine receptor 2 protein