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Browse our Ghrelin/obestatin Prepropeptide Proteins (GHRL)

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Ghrelin/obestatin Prepropeptide Proteins (GHRL)
On are 17 Ghrelin/obestatin Prepropeptide (GHRL) Proteins from 8 different suppliers available. Additionally we are shipping Ghrelin/obestatin Prepropeptide Antibodies (260) and Ghrelin/obestatin Prepropeptide Kits (96) and many more products for this protein. A total of 443 Ghrelin/obestatin Prepropeptide products are currently listed.
2210006E23Rik, Gh1-1, GHR, GRHL, m46, MTLRP, MTLRP-AP, MTLRPAP
list all proteins Gene Name GeneID UniProt
Mouse GHRL GHRL 58991 Q9EQX0
GHRL 51738 Q9UBU3
Rat GHRL GHRL 59301 Q9QYH7

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Ghrelin/obestatin Prepropeptide Proteins (GHRL) by Origin

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Top referenced Ghrelin/obestatin Prepropeptide Proteins

  1. Human GHRL Protein expressed in Escherichia coli (E. coli) - ABIN413323 : Iantorno, Chen, Kim, Tesauro, Lauro, Cardillo, Quon: Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells. in American journal of physiology. Endocrinology and metabolism 2007 (PubMed)

  2. Human GHRL Protein expressed in Escherichia coli (E. coli) - ABIN620667 : Ferro, Gutiérrez-Gallego, Bosch, Farré, Segura: Fit-for-Purpose Radio Receptor Assay for the Determination of Growth Hormone Secretagogues in Urine. in Journal of biomolecular screening 2015 (PubMed)

  3. Human GHRL Protein expressed in Escherichia coli (E. coli) - ABIN666671 : Tschöp, Smiley, Heiman: Ghrelin induces adiposity in rodents. in Nature 2000 (PubMed)

More Proteins for Ghrelin/obestatin Prepropeptide Interaction Partners

Mouse (Murine) Ghrelin/obestatin Prepropeptide (GHRL) interaction partners

  1. Des (show DES Proteins)-acylated ghrelin reduced blood-brain barrier disruption in vivo and attenuated the hyper-permeability of mouse cerebral microvascular endothelial cells after oxygen glucose deprivation.

  2. des (show DES Proteins)-acyl ghrelin produces an anxiogenic effect under nonstressed conditions, but this switches to an anxiolytic effect under stress

  3. data support the notion that ghrelin activates ParaVentricular Nucleus CRF (show CRH Proteins) neurons via inhibition of local GABAergic tone, in an Arcuate nucleus-independent manner.

  4. ghrelin may mediate part of its metabolic actions through modulation of hypothalamic astrocytes and that this effect could involve astrocyte mediated changes in local glucose and glutamate (show GRIN1 Proteins) metabolism that alter the signals/nutrients reaching neighboring neurons.

  5. These studies reemphasize the beneficial effects imparted by co-administration of obestatin and CCK8 (show CCK Proteins) and their potential use towards countering obesity.

  6. Stress in a postpartum mother has persistent effects on the body weight of their offspring. Increased ghrelin and decreased leptin (show LEP Proteins) expression in the stomach may play a role in these effects.

  7. Data (including data from studies in cell line from knockout mice) suggest high incorporation of long-chain fatty acids, partly mediated by Acsl1 (show Acsl1 Proteins), plays role in supply of octanoic acid for ghrelin acylation/lipoylation in ghrelin-producing cells.

  8. Data show that chronic caloric restriction (CR) alters hypothalamic agouti-related protein (Agrp (show AGRP Proteins)) and neuropeptide Y (Npy (show NPY Proteins)) gene expression similarly in Ghrelin+/+, Ghrelin-/-, ghrelin receptor Ghsr (show GHSR Proteins)+/+, and Ghsr (show GHSR Proteins)-/- mice.

  9. The expression of ghrelin and GH secretagogue receptor 1a [GHSR1a] in cerebral arteries and the effects of ghrelin analogs on cerebrovascular function are reproted.[GHSR1a]

  10. Pax6 (show PAX6 Proteins) inactivation in the adult pancreas reveals ghrelin as endocrine cell maturation marker.

Rabbit Ghrelin/obestatin Prepropeptide (GHRL) interaction partners

  1. Study suggests that ghrelin promotes the growth and osteogenic differentiation of rBMSC primarily through the ERK1/2 pathway.

Rainbow Trout (Oncorhynchus mykiss) Ghrelin/obestatin Prepropeptide (GHRL) interaction partners

  1. Data show that ghrelin was identified in cultured differentiated adipocytes, but did not influence either preadipocyte proliferation or differentiation, indicating that it may have other adipose-related roles.

  2. data provides evidence for the first time in fish of a possible modulatory role of ghrelin on the metabolic regulation by fatty acid of food intake occurring in the hypothalamus

Human Ghrelin/obestatin Prepropeptide (GHRL) interaction partners

  1. In hemodialysis patients, plasma ghrelin level was associated with the endoscopic and serological severity of atrophy related to H. pylori infection.

  2. studies indicate that pharmacological targeting of the endogenous ghrelin system is a valuable approach to treat metabolic complications.

  3. Patients with intestinal metaplasia, a known precursor of gastric cancer, had significantly less plasma ghrelin levels and ghrelin/obestatin (G/O) ratio than those without intestinal metaplasia.

  4. The mechanism may be that ghrelin up-regulates the expression of cyclin D1 (show CCND1 Proteins) via regulating Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway, which has an intimate relationship with lung diseases. These results suggested the possible role of ghrelin in treating diabetic lung diseases, especially in view of its low toxicity in humans.

  5. These results demonstrate that ghrelin lightens LPS (show IRF6 Proteins)-induced apoptosis of human alveolar epithelial cells partly through activating the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) and ERK (show EPHB2 Proteins) pathway and thereby might benefit alleviating septic ALI.

  6. Ghrelin expression was associated with better breast cancer specific survival in univariate analyses (OR 0.55, 95% CI 0.36-0.84) and in multivariate models, adjusted for endocrine treatment and age (OR 0.57, 95% CI 0.36-0.89). Obestatin expression was non-informative (OR 1.2, 95% CI 0.60-2.46).

  7. Mothers with gestational diabetes (GD) and type 2 diabetes mellitus (T2DM) had significantly lower ghrelin levels. compared to the healthy mothers.

  8. Data suggest that a 20 km run significantly decreases plasma acylated ghrelin concentrations and energy intake during a subsequent buffet meal among well-trained long distance runners; this study on appetite regulation was conducted on male long-distance runners in Japan.

  9. analysis of the relationship between skinfold thickness and serum leptin (show LEP Proteins), ghrelin, adiponectin (show ADIPOQ Proteins), and resistin (show RETN Proteins) levels in infants of diabetic mothers

  10. Data suggest that high-salt intake significantly increases fasting ghrelin levels; it has been hypothesized that by up-regulating fasting ghrelin in healthy subjects, a high-salt diet may up-regulate appetite causing hyperphagia which would then lead to overweight/obesity.

Cow (Bovine) Ghrelin/obestatin Prepropeptide (GHRL) interaction partners

  1. GHRL is an important candidate gene that may be used to identify genetic variations that influence traits of economic importance in beef cattle

  2. Single nucleotide polymorphisms identified in the promoter region of the ghrelin gene could cause changes in the putative transcription factor (show TCF19 Proteins) binding sites.

  3. The effects of dietary energy on the metabolism of ghrelin, leptin (show LEP Proteins) and growth hormone secretagogue receptor (show GHSR Proteins) in blood and tissues of steers are reported.

  4. ghrelin declined after glucose infusion and before the insulin (show INS Proteins) peak; post-nadir surge in ghrelin may be regulated by the decline in circulating concentrations of glucose and nonesterified fatty acids

Goat Ghrelin/obestatin Prepropeptide (GHRL) interaction partners

  1. present findings suggest that ghrelin may play an important role in regulation of mammary function in lactating dairy goats via GHSR (show GHSR Proteins)-1a

Pig (Porcine) Ghrelin/obestatin Prepropeptide (GHRL) interaction partners

  1. These expression data may indicate that factors other than ghrelin and leptin (show LEP Proteins) are more involved in the regulation of feed intake in pigs apparently acclimated to heat stress.

  2. slc30A8 (show SLC30A8 Proteins) colocalizes with ghrelin and motilin (show MLN Proteins) in the gastrointestinal tract of pigs

  3. Studied an alternative vascular approach to the modulation of gastric ghrelin levels..

  4. Obestatin enhances proliferation and differentiation of preadipocytes promoting PPARgamma (show PPARG Proteins) and C/EBPa (show CEBPA Proteins) expression, and inhibiting preadipocyte apoptosis by decreasing expression of Caspase-3 (show CASP3 Proteins), Caspase-7 (show CASP7 Proteins) and Caspase-9 (show CASP9 Proteins).

  5. The expression of ghrelin in the digestive tract of low birth weight and normal weight piglets is reported.

  6. Data suggest that a dietary factor (here, high levels of dietary copper) is able to up-regulate expression of ghrelin in the fundic gland of growing pigs; the diets tested in this study also increase feed intake and promote weight gain.

  7. Ghrelin immunolocalization in the gastrointestinal tract of pigs at different ages were studied and it was concluded that gastric ghrelin expression is not related merely to age but could also potentially be influenced by food intake.

  8. BsrI polymorphism at the ghrelin gene locus is potentially associated with carcass and meat quality traits.

  9. Plasma concentrations of ghrelin were greater before feeding and decreased after feeding in pigs fed once per day; there was no consistent pattern to ghrelin secretion in the ad libitum fed group.

  10. glucose output by primary porcine hepatocytes in suspension culture, after incubation with acylated ghrelin (AG), unacylated ghrelin (UAG), and hexarelin (HEX).

Ghrelin/obestatin Prepropeptide (GHRL) Protein Profile

Protein Summary

This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake\; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression.

Alternative names and synonyms associated with Ghrelin/obestatin Prepropeptide (GHRL)

  • ghrelin (Ghrl)
  • ghrelin-like (LOC100349547)
  • ghrelin/obestatin preprohormone (ghrl)
  • ghrelin/obestatin prepropeptide (GHRL)
  • ghrelin/obestatin prepropeptide (Ghrl)
  • 2210006E23Rik protein
  • Gh1-1 protein
  • GHR protein
  • GRHL protein
  • m46 protein
  • MTLRP protein
  • MTLRP-AP protein
  • MTLRPAP protein

Protein level used designations for GHRL

appetite-regulating hormone , growth hormone secretagogue , growth hormone-releasing peptide , motilin-related peptide , preproghrelin , proghrelin , ghrelin , ghrelin, growth hormone secretagogue receptor ligand , ghrelin/obestatin preprohormone , prepro-appetite regulatory hormone , Appetite-regulating hormone , Growth hormone secretagogue , Growth hormone-releasing peptide , prepro-ghrelin , GH releasing peptide , motilin related peptide , growth hormone receptor

58991 Mus musculus
100349547 Oryctolagus cuniculus
100136596 Oncorhynchus mykiss
51738 Homo sapiens
59301 Rattus norvegicus
281192 Bos taurus
100861189 Capra hircus
396728 Sus scrofa
493844 Felis catus
403587 Canis lupus familiaris
442996 Ovis aries
408185 Gallus gallus
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