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Role of cysteine 341 and arginine 348 of GLP-1 receptor in G-protein coupling.
GLP1-R may represent a novel target for treating bronchial hyperresponsiveness.
Our studies show that GLP-1R is widely expressed throughout the human hypothalamus. The decreased expression of GLP-1R in the PVN and IFN of T2DM patients may be related to the dysregulation of feeding behavior and glucose homeostasis in type 2 diabetes mellitus.
The effects of GLP-1 (show GCG Proteins)-based therapies on blood glucose in type 2 diabetics are not mediated through microvascular responses.
In conclusion, exenatide significantly improves coronary endothelial function in patients with newly diagnosed type 2 diabetes. The effect may be mediated through activation of AMPK (show PRKAA1 Proteins)/PI3K (show PIK3CA Proteins)-Akt (show AKT1 Proteins)/eNOS (show NOS3 Proteins) pathway via a GLP-1R/cAMP-dependent mechanism.
A higher likelihood of attaining A1c goal levels were observed when a GLP-1R agonists was initiated.
Immunohistochemistry of human ileum tissues was performed in this study, which showed that TAS2R38 (show TAS2R38 Proteins) was co-localized with glucagon-like peptide 1 (GLP-1 (show GCG Proteins)) in enteroendocrine L-cells.
Data suggest that three conserved positively charged residues located at extracellular ends of transmembrane helices 3, 4 and 5 of GLP1R are essential for high affinity agonist binding and conformational transitions linked to pleiotropic effector coupling through stabilisation of extracellular domains.
The rate of homologous desensitization and internalization of the GLP-1R has been determined in a transgenic cell line system.
In the glucagon receptor (GCGR (show GCGR Proteins)) and glucagon-like peptide-1 receptor (GLP-1R), the extracellular domain is required for signaling even when the hormone is covalently linked to the transmembrane domain.
In glucagon (show GCG Proteins)-like peptide receptor (GLP-1R) expressing cells, small molecule agonists induced cAMP production but caused no intracellular Ca2 (show CA2 Proteins)+ accumulation, ERK (show EPHB2 Proteins) phosphorylation or hGLP-1R internalisation.
Enhanced beta-cell GLP-1R signaling contributes to improved glucose regulation after vertical sleeve gastrectomy by promoting increased glucose-stimulated insulin (show INS Proteins) secretion.
Results suggest a detectable but only modest role for GLP-1R signaling in mediating the effects of Roux-en-Y gastric bypass and that this role is limited to its well-described action on glucose regulation.
Hypothalamic Glp1r is sufficient but not necessary for regulation of energy balance and glucose homeostasis.
Genetic deletion of both GLP-1 (show GCG Proteins) and GIP (show GIP Proteins) receptors reveals that they are required to maintain an adequate islet number in adulthood and to maintain normal beta cell responses to glucose.
present study provides critical insights regarding the nature by which GLP-1 (show GCG Proteins) signaling controls reinforced behaviors and underscores the importance of both peripheral and central GLP-1R signaling for the regulation of addictive disorders.
CB1 (show CNR1 Proteins) activation negatively impacts GLP-1R-mediated insulin (show INS Proteins) secretion.
These differential effects of exogenous Glp1r in nondiabetic and diabetic mice suggest that downregulation of Glp1r might be required to slow the progression of beta-cell failure under diabetic conditions.
although endogenous GLP-1R signalling contributes to increased brown adipose tissue thermogenesis, this mechanism does not play a significant role in the food intake-independent body weight lowering effect of the GLP-1 (show GCG Proteins) mimetic liraglutide in obese mice
GLP-1R is present in pancreatic acinar cells and that GLP-1 (show GCG Proteins) can regulate secretion through its receptor and cAMP signaling pathway.
GLP1R is expressed in mouse retina. GLP-1R protein abundance was independent of the presence of diabetes.
induces insulin secretion\; mediates neuroendocrine signaling of feeding behavior\; mediates cardiovascular response and increased blood pressure
glucagon-like peptide 1 receptor
, glucagon-like peptide 1 receptor-like
, GLP-1 receptor
, pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1