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Role of cysteine 341 and arginine 348 of GLP-1 receptor in G-protein coupling.
The rate of homologous desensitization and internalization of the GLP-1R has been determined in a transgenic cell line system.
In the glucagon receptor (GCGR (show GCGR Proteins)) and glucagon-like peptide-1 receptor (GLP-1R), the extracellular domain is required for signaling even when the hormone is covalently linked to the transmembrane domain.
In glucagon (show GCG Proteins)-like peptide receptor (GLP-1R) expressing cells, small molecule agonists induced cAMP production but caused no intracellular Ca2 (show CA2 Proteins)+ accumulation, ERK (show EPHB2 Proteins) phosphorylation or hGLP-1R internalisation.
We aimed to investigate whether genetic variations in glucagon (show GCG Proteins)-like peptide receptor are associated with responses to dipepdityl peptidase-4 (show PEPD Proteins) inhibitors in patients with type 2 diabetes. Polymorphism in the GLP-1 receptor may influence DPP-4 (show DPP4 Proteins) inhibitor response.
Results suggest that pancreatic ductal adenocarcinoma (PDAC) cells or their precursor lesions do not overexpress glucagon-like peptide-1 receptor (GLP-1R) compared with non-neoplastic pancreatic cells.
The molecular dynamics simulations of wild-type and mutant GLP (show RCBTB1 Proteins)-1R.ligand complexes provided molecular insights into GLP-1R-specific recognition mechanisms for the N terminus of GLP-1 (show GCG Proteins) by residues in the 7TM pocket and explained how glucagon (show GCG Proteins)-mimicking GLP-1 (show GCG Proteins) mutants restored binding affinity for (glucagon receptor (show GCGR Proteins) -mimicking) GLP-1R mutants.
NMR-determined structure of a high-potency cyclic conformationally-constrained 11-residue analogue of GLP-1 (show GCG Proteins) was also docked into the receptor-binding site.
Lack of association of rs6923761 GLP-1 R polymorphism with weight loss.
An association was found between the rs6923761 GLP-1 receptor polymorphism and basal GLP-1 (show GCG Proteins) levels in diabetes mellitus type 2 patients.
although GLP-1R is not an independent prognostic factor in PDAC patients, it appears to have some implications for pancreatic ductal adenocarcinoma metastatic ability
Genetic deletion of both GLP-1 (show GCG Proteins) and GIP (show GIP Proteins) receptors reveals that they are required to maintain an adequate islet number in adulthood and to maintain normal beta cell responses to glucose.
present study provides critical insights regarding the nature by which GLP-1 (show GCG Proteins) signaling controls reinforced behaviors and underscores the importance of both peripheral and central GLP-1R signaling for the regulation of addictive disorders.
CB1 (show CNR1 Proteins) activation negatively impacts GLP-1R-mediated insulin (show INS Proteins) secretion.
These differential effects of exogenous Glp1r in nondiabetic and diabetic mice suggest that downregulation of Glp1r might be required to slow the progression of beta-cell failure under diabetic conditions.
although endogenous GLP-1R signalling contributes to increased brown adipose tissue thermogenesis, this mechanism does not play a significant role in the food intake-independent body weight lowering effect of the GLP-1 (show GCG Proteins) mimetic liraglutide in obese mice
GLP-1R is present in pancreatic acinar cells and that GLP-1 (show GCG Proteins) can regulate secretion through its receptor and cAMP signaling pathway.
GLP1R is expressed in mouse retina. GLP-1R protein abundance was independent of the presence of diabetes.
The data of this study reveal a novel role of GLP-1R in dorsal lateral septum function driving behavioral responses to cocaine.
GLP-1R agonism significantly reduced alcohol consumption in a mouse model of alcohol dependence.
these data provide novel evidence that lipotoxicity decreases the mesangial GLP-1R expression in intact cells and in vivo.
induces insulin secretion\; mediates neuroendocrine signaling of feeding behavior\; mediates cardiovascular response and increased blood pressure
glucagon-like peptide 1 receptor
, glucagon-like peptide 1 receptor-like
, GLP-1 receptor
, pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1