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Browse our HLA-DRB1 Proteins (HLA-DRB1)

Full name:
HLA Class II DR beta 1 Proteins (HLA-DRB1)
On www.antibodies-online.com are 27 HLA Class II DR beta 1 (HLA-DRB1) Proteins from 4 different suppliers available. Additionally we are shipping HLA-DRB1 Antibodies (196) and HLA-DRB1 Kits (7) and many more products for this protein. A total of 234 HLA-DRB1 products are currently listed.
Synonyms:
DRB1, DRw10, HLA-DR1B, HLA-DRB, MGC108235, SS1
list all proteins Gene Name GeneID UniProt
HLA-DRB1 3123 P01912 , P01911 , Q29974
HLA-DRB1    

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HLA-DRB1 Proteins (HLA-DRB1) by Origin

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Human HLA Class II DR beta 1 (HLA-DRB1) interaction partners

  1. possible interaction between smoking and HLA-DRB1-associated antigen presentation in risk of follicular lymphoma

  2. There is an association between HLA-DRB1 *15:01 in GERD patients with H. pylori positive patients.

  3. findings suggest that in Hodgkin's lymphoma patients, DRB1*11 alleles, and in non-Hodgkin's lymphoma patients, DRB1*04 alleles might be presumptive predisposing factors.

  4. Data indicate that increase of alveolar macrophages is associated with smoking status and HLA-DRB1*15 allele..

  5. DRB1*03 and DRB1*13 were significantly associated with autoimmune liver and biliary diseases in Finnish paediatric patients.

  6. HLA-DRB1 allelic variations are associated with rheumatoid arthritis in Asian patients.

  7. DRB1*03 was positively associated with risk of asthma; DRB1*15 was negatively associated with risk of asthma; Subgroup analysis by age revealed that DRB1*03, DRB1*04, DRB1*09, and DRB1*15 were associated with asthma in children. Subgroup analysis by ethnicity showed that DRB1*03 and DRB1*15 were associated with asthma in whites, and DRB1*07 and DRB1*14 were associated with asthma in Asians.

  8. HLA-DRB1*/DQB1* alleles and haplotypes strongly predispose South Indian population to ischaemic stroke

  9. DRB1 (show RBM45 Proteins)*13:02 (P = 0.0011, Pc = 0.0319, odds ratio [OR] 0.46, 95% confidence interval [CI] 0.29-0.73), DRB1 (show RBM45 Proteins)*14:06 (P = 6.60X10-5, Pc = 0.0020, OR 0.05, 95%CI 0.01-0.41), DQB1*03:01 (P = 0.0009, Pc = 0.0150, OR 0.56, 95%CI 0.40-0.79), and DPB1 (show HLA-DPB1 Proteins)*02:01 (P = 5.16X10-6, Pc = 8.77X10-5, OR 0.52, 95%CI 0.39-0.69) were protectively associated with Systemic Sclerosis in Japanese.

  10. a positive correlation of HLA-DRB1*12 and a negative correlation of HLA-DRB1*13 with younger patientsTNFb4 allele's negative association with older patients displaying higher PSA (show PLAG1 Proteins) levels, higher GS and positive surrounding tissue involvement; positive association of TNFb5 allele for both older and younger patients

HLA-DRB1 Protein Profile

Protein Summary

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide\; exons 2 and 3 encode the two extracellular domains\; exon 4 encodes the transmembrane domain\; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Alternative names and synonyms associated with HLA-DRB1

  • major histocompatibility complex, class II, DR beta 1 (hla-drb1)
  • major histocompatibility complex, class II, DR beta 1 (HLA-DRB1)
  • DRB1 protein
  • DRw10 protein
  • HLA-DR1B protein
  • HLA-DRB protein
  • MGC108235 protein
  • SS1 protein

Protein level used designations for HLA-DRB1

major histocompatibility complex, class II, DR beta 1 , DW2.2/DR2.2 , HLA class II histocompatibility antigen, DR-1 beta chain , MHC class II HLA-DR beta 1 chain , MHC class II HLA-DR-beta cell surface glycoprotein , MHC class II HLA-DRw10-beta , MHC class II antigen , human leucocyte antigen DRB1 , lymphocyte antigen DRB1

GENE ID SPECIES
734125 Xenopus (Silurana) tropicalis
3123 Homo sapiens
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