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Human Polyclonal UCN3 Primary Antibody for ELISA, WB - ABIN238662
Jiang, Michal, Williams, Daniels, Kunej: Cross species association examination of UCN3 and CRHR2 as potential pharmacological targets for antiobesity drugs. in PLoS ONE 2007
Human Polyclonal UCN3 Primary Antibody for IHC, IHC (p) - ABIN4364471
Hua, Shang, Martinez, Freeby, Gallagher, Ludwig, Deng, Greenberg, Leduc, Chung, Goland, Leibel, Egli: iPSC-derived β cells model diabetes due to glucokinase deficiency. in The Journal of clinical investigation 2013
circulating levels elevated and positively correlated with C-reactive protein (show CRP Antibodies) in polycystic ovary syndrome
results show that activation of CRH (show CRH Antibodies) receptors by CRH (show CRH Antibodies) ligands stimulates VEGF-A (show VEGFA Antibodies) expression in intestinal epithelial cells through the cAMP/CREB (show CREB1 Antibodies) pathway
The paracrine actions of Ucn3 activate a negative feedback loop that promotes somatostatin (show SST Antibodies) release to ensure the timely reduction of insulin (show INS Antibodies) secretion upon normalization of plasma glucose.
The molecular modifications of urocortin 3[36-38] led to an improved understanding of the relationship between molecular structure and biological activity of this peptide, could be further tested for possible clinical treatment of depression
Data suggest that UCN3 expression can serve as a late stage maturation/differentiation marker in beta-cells during pancreogenesis. [REVIEW]
SCP (show RAG1AP1 Antibodies) inhibits a subpopulation of PVN neurons, especially OTergic magnocellular neurons, by enhancing the activity of GIRK channels via CRF-R2 (show CRHR2 Antibodies)
study showed that Ucn2 (show UTS2 Antibodies) and Ucn3 differentially regulate the LPS (show IRF6 Antibodies)-induced TNF-alpha (show TNF Antibodies) and IL-10 (show IL10 Antibodies) expression and secretion in trophoblast explants acting through CRH-R2 (show CRHR2 Antibodies). Ucn3 has an anti-inflammatory effect.
These data suggest a possible involvement of urocortin 2 (show UCN2 Antibodies) and Ucn 3 in the mechanisms of endometriosis.
Confirm the anti-inflammatory function of VIP (show Vip Antibodies), through the modulation of the expression of CRF (show CRH Antibodies) system that impacts in a reduction of mediators with inflammatory/destructive functions.
Placental Ucn2 (show UTS2 Antibodies) and Ucn3 expression is sensitive to O(2) tensions and mediated by HIF-1alpha (show HIF1A Antibodies). In preeclampsia, the increased expression of both peptides may reflect a response to the oxidative stress.
Ucn3 KO mice displayed significantly increased ethanol intake and preference compared with WT. There were no long-term effects of chronic pain on alcohol drinking behavior, regardless of genotype.
This study aims to investigate the cellular localization of CRF (show CRH Antibodies) and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
UCN3 expression enhances glucose disposal and signalling in muscle by an autocrine/paracrine mechanism that is separate from its pro-hypertrophic effects.
Leptin (show LEP Antibodies) regulates corticotropin-releasing factor (show CRH Antibodies) and urocortin 2 (show UTS2 Antibodies)/3 mRNA in hypothalamic neurons.
Urocortin 3 acting on CRFR2 (show CRHR2 Antibodies) in skeletal muscle of Ucn3(+) mice results in a metabolic phenotype, with lean body composition and protection against diet-induced obesity and hyperglycaemia.
In this study, the intracerebroventricularly administered Ucn3 exerted an inhibitory effect on food intake, although the potency for decreasing food intake differed with the experimental conditions.
The results of this study suggested a novel role for UCN3 and CRH-R2 (show CRHR2 Antibodies) related to the processing of social cues and to the establishment of social memories.
demonstrate the involvement of the hypothalamic neuropeptide Urocortin-3 in modulating septal and hypothalamic nuclei responsible for anxiety-like behaviors and metabolic functions, respectively.
pancreatic Ucn III acting through CRFR2 (show CRHR2 Antibodies) is involved in the local regulation of glucagon (show GCG Antibodies) and insulin (show INS Antibodies) secretion.
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.
, urocortin 3
, prepro-urocortin 3
, ucn III
, urocortin III
, Urocortin II
, Urocortin III
, urocortin 3 (stresscopin)