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Targeting FOXM1 with thiostrepton decreased FOXM1 mRNA expression and its downstream targets such as CCNB1 (show CCNB1 ELISA Kits) and CDC25B (show CDC25B ELISA Kits), leading to cell death in both cell lines and patients' ascites cancer cells.
these results demonstrate that the reversible acetylation of FOXM1 by p300/CBP (show CREBBP ELISA Kits) and SIRT1 (show SIRT1 ELISA Kits) modulates its transactivation function
this study shows that FOXM1 confers resistance to gefitinib in lung adenocarcinoma via a MET/AKT (show AKT1 ELISA Kits)-dependent positive feedback loop
FOXM1 has roles in cell cycle, pluripotency genes and stem cell pathways in sarcoma [review]
Cells with ectopic FOXM1 expression demonstrate considerable ( approximately 20%, P < 0.001) growth advantage despite MET targeting.
FoxM1 is an established therapeutic target for several cancers.
Data indicate that forkhead box M1 (FOXM1) is highly expressed in the erythroid population suggesting a role of FOXM1 in erythropoiesis.
this study provided mechanistic evidences to support the positive regulatory function of FOXM1 in HSPA5 (show HSPA5 ELISA Kits) expression in colorectal cancer
We identified FOXM1 and FOXQ1 (show FOXQ1 ELISA Kits) as novel prognostic biomarkers in colorectal cancer and miR (show MLXIP ELISA Kits)-342 as a novel regulator of both FOXM1 and FOXQ1 (show FOXQ1 ELISA Kits)
High FOXM1 expression is associated with malignant pleural mesothelioma.
Upregulated ROS (show ROS1 ELISA Kits) induced by FABP4 (show FABP4 ELISA Kits) was of significance in activating FoxM1 leading to airway inflammation and epithelial barrier dysfunction.
Interactions between the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) and the Kras/ERK (show EPHB2 ELISA Kits)/Foxm1 pathways are essential to restrict SOX9 (show SOX9 ELISA Kits) expression in basal cells during pulmonary branching morphogenesis
YAP (show YAP1 ELISA Kits) cooperates with FOXM1 to contribute to chromosome instability in hepatocellular carcinoma.
RCM-1 (show TNNI3 ELISA Kits) blocked the nuclear localization and increased the proteasomal degradation of Forkhead box M1 (FOXM1), a transcription factor critical for the differentiation of goblet cells from airway progenitor cells.
These data implicate the insulin (show INS ELISA Kits)-FoxM1/PLK1 (show PLK1 ELISA Kits)/CENP-A (show CENPA ELISA Kits) pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.
EGF (show EGF ELISA Kits) promotes FoxM1 expression through the ERK (show EPHB2 ELISA Kits) signal pathway
FoxM1 induction in the pulmonary vasculature was inhibited by a p110gamma (show PIK3CG ELISA Kits)-selective inhibitor and in Pik3cg (show PIK3CG ELISA Kits)(-/-) mice after LPS (show TLR4 ELISA Kits) challenge. Defective vascular repair in Pik3cg (show PIK3CG ELISA Kits)-/- mice results from impaired FoxM1 expression
we suggest that proper regional decidualization and polyploidy development requires FoxM1 signaling downstream of Hoxa10 (show HOXA10 ELISA Kits) and cyclin D3 (show CCND3 ELISA Kits).
FOXM1 and CENPF (show CENPF ELISA Kits) are master regulators of prostate cancer malignancy, and can serve as drug response markers for antineoplastic drugs efficiency.
Both gain-of-function and loss-of-function TP53 (show TP53 ELISA Kits) mutations contribute to overexpression of FoxM1 in high-grade serous ovarian cancer.
the sequence and expression pattern of FoxM1 (fork head box M1) transcription factor in Xenopus laevis embryos are described
Results suggest that FoxM1 functions to link cell division and neuronal differentiation in early Xenopus embryos.
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene.
forkhead box protein M1
, forkhead box M1
, forkhead box protein M1-like
, Forkhead, drosophila, homolog-like 16
, HNF-3/fork-head homolog 11
, M-phase phosphoprotein 2
, MPM-2 reactive phosphoprotein 2
, forkhead-related protein FKHL16
, hepatocyte nuclear factor 3 forkhead homolog 11
, transcription factor Trident
, winged-helix factor from INS-1 cells
, forkhead homolog 16
, winged-helix transcription factor Trident
, INS-1 winged helix