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anti-Mouse (Murine) RNF168 Antibodies:
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anti-Rat (Rattus) RNF168 Antibodies:
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Human Polyclonal RNF168 Primary Antibody for EIA, WB - ABIN500624
Doil, Mailand, Bekker-Jensen, Menard, Larsen, Pepperkok, Ellenberg, Panier, Durocher, Bartek, Lukas, Lukas: RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. in Cell 2009
RNF168, in complex with RAD6A (show ube2a Antibodies) or RAD6B (show UBE2B Antibodies), is activated in the DNA-damage-induced protein ubiquitination cascade.
Rnf168 is important for maintaining genomic integrity, and it cooperates with p53 (show TP53 Antibodies) in suppressing tumorigenesis.
Further mining of the UBE2U (show UBE2U Antibodies) interactome uncovered its cognate E3 RNF17 (show RNF17 Antibodies) as a novel factor that, via the radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties (RIDDLE) syndrome protein RNF168, enforces DNA damage responses.
The association of RNF168 with PML (show PML Antibodies) NBs (show NBN Antibodies) resulted in increased ubiquitylation.
Results reveal an important role of USP7 (show USP7 Antibodies) in regulating ubiquitin-dependent signaling via stabilization of RNF168.
CK2 (show CSNK2A1 Antibodies)/WIP1 (show PPM1D Antibodies)-mediated modulation of LSD1 (show KDM1A Antibodies) phosphorylation facilitates RNF168-dependent ubiquitination and recruitment of 53BP1 (show TP53BP1 Antibodies) to the DNA damage sites.
The ubiquitin ligase RNF168 is strictly dependent on the activity that UbK27 is required to promote chromatin ubiquitination following DNA damage.
Finding that RNF8 (show RNF8 Antibodies) is less abundant than RNF168 identifies RNF8 (show RNF8 Antibodies) as a rate-limiting determinant of focal repair complex assembly
Depletion of RNF8 (show RNF8 Antibodies) or RNF168 blocks the degradation of diffusely localized nuclear 53BP1 (show TP53BP1 Antibodies).
The E3 ligase RNF168 promotes both H2A ubiquitylation and neddylation. RNF168 is itself a substrate for NEDD8, and neddylation of RNF168 is necessary for its E3 ubiquitin activity.
The acidic patch functions within the nucleosome as nucleosomes containing a mutated acidic patch exhibit defective H2A/H2AXub by RNF168 and RING1B (show RNF2 Antibodies)/BMI1 (show BMI1 Antibodies) in vitro
Taken together, the results suggested that USP3 (show USP3 Antibodies) is a negative regulator of ubiquitination signaling, counteracting RNF168- and RNF8 (show RNF8 Antibodies)-mediated ubiquitination
This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome.
E3 ubiquitin-protein ligase RNF168
, ring fnger protein 168