Browse our HVCN1 Proteins (HVCN1)

Full name:
Hydrogen Voltage-Gated Channel 1 Proteins (HVCN1)
On are 3 Hydrogen Voltage-Gated Channel 1 (HVCN1) Proteins from 2 different suppliers available. Additionally we are shipping HVCN1 Antibodies (39) and HVCN1 Kits (6) and many more products for this protein. A total of 51 HVCN1 products are currently listed.
0610039P13Rik, AI450555, BTS, HV1, HVCN1, mVSOP, RGD1310788, Vsop, vsx1, zgc:92181
list all proteins Gene Name GeneID UniProt
HVCN1 84329 Q96D96
HVCN1 74096 Q3U2S8
Rat HVCN1 HVCN1 304485  

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Human Hydrogen Voltage-Gated Channel 1 (HVCN1) interaction partners

  1. Inhibition of Hv1 channels by Zn(2+).

  2. CREBBP (show CREBBP Proteins) mutations were associated with inferior progression-free survival (PFS), whereas mutations in previously unreported HVCN1, a voltage-gated proton channel-encoding gene and B-cell receptor signaling modulator, were associated with improved PFS.

  3. Our data demonstrated that the expression of Hv1 in pancreatic islet beta-cells regulates insulin (show INS Proteins) secretion through regulating Ca(2 (show CA2 Proteins)+) homeostasis.

  4. The main properties of the voltage-gated proton channel (HV1) are described in this review, along with what is known about how the channel protein structure accomplishes its functions. [review]

  5. Hv1 activity displays hysteresis

  6. A shorter isoform of HVCN1 with enhanced gating is specifically enriched in malignant B cells.

  7. Divalent metal binding causes a conformational change in human the Hv1 c-terminal domain.

  8. analysis of of the C-terminal domain of voltage-gated proton channel HV1 and the thermodynamic characteristics of Zn(2) binding to this domain

  9. Salt bridge networks and the hydrophobic plug function as the gate in Hv1 channels; outward movement of the fourth transmembrane segment leads to the opening of this gate.

  10. Results suggest that Hv1 may be used as a potential biomarker for diagnosis and prognosis of colorectal carcinoma, and a potential target for anticancer drugs in colorectal cancer therapy.

Mouse (Murine) Hydrogen Voltage-Gated Channel 1 (HVCN1) interaction partners

  1. microglial Hv1 proton channel is a unique target for modulation of microglial M1/M2 polarization in the pathogenesis of ischemic stroke

  2. Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1.

  3. The voltage-gated proton channel Hv1/VSOP inhibits neutrophil granule release

  4. Our data demonstrated that the expression of Hv1 in pancreatic islet beta-cells regulates insulin (show INS Proteins) secretion through regulating Ca(2 (show CA2 Proteins)+) homeostasis.

  5. Eosinophils require proton channel HVCN1 for optimal reactive oxygen species generation and prevention of activation-induced cell death.

  6. Functional expression of voltage-gated proton (Hv1) channels is characterized, for the first time, in mouse bone marrow-derived dendritic cells.

  7. inhibition of Hv1 function via knockdown of Hv1 expression can effectively retard cancer growth

  8. Hv1 channels maintain a physiological membrane potential during the respiratory burst of neutrophils by providing a compensating charge for the electrons transferred by NOX2 (show CYBB Proteins) from NADPH (show FDXR Proteins) to superoxide.

  9. Review of structural organization and gating of Hv1 channels discusses relationship between gating of Hvcn1 and the gating of ion-conducting pores recently discovered in the voltage-sensing domains of mutant voltage-gated potassium and sodium channels.

  10. HVCN1 -deficieent B cells show a defct in ROS production, which causes less signal transduction through impaired BCR-dependent oxidation of SHP-1.

HVCN1 Protein Profile

Protein Summary

This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with HVCN1

  • hydrogen voltage-gated channel 1 (hvcn1)
  • hydrogen voltage-gated channel 1 (HVCN1)
  • voltage-gated hydrogen channel 1 (hvcn1)
  • hydrogen voltage-gated channel 1 (Hvcn1)
  • 0610039P13Rik protein
  • AI450555 protein
  • BTS protein
  • HV1 protein
  • HVCN1 protein
  • mVSOP protein
  • RGD1310788 protein
  • Vsop protein
  • vsx1 protein
  • zgc:92181 protein

Protein level used designations for HVCN1

HV1 , voltage-gated hydrogen channel 1 , hydrogen voltage-gated channel 1 , voltage sensor domain-only protein

436618 Danio rerio
452241 Pan troglodytes
496712 Xenopus (Silurana) tropicalis
608547 Canis lupus familiaris
616570 Bos taurus
778897 Ciona intestinalis
100152115 Sus scrofa
84329 Homo sapiens
74096 Mus musculus
416871 Gallus gallus
304485 Rattus norvegicus
496219 Xenopus laevis
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