Browse our UCP1 Proteins (UCP1)

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Uncoupling Protein 1 (Mitochondrial, Proton Carrier) Proteins (UCP1)
On are 15 Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) Proteins from 5 different suppliers available. Additionally we are shipping UCP1 Antibodies (110) and UCP1 Kits (30) and many more products for this protein. A total of 160 UCP1 products are currently listed.
list all proteins Gene Name GeneID UniProt
UCP1 7350 P25874
UCP1 22227 P12242
UCP1 24860 P04633

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UCP1 Proteins (UCP1) by Origin

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More Proteins for UCP1 Interaction Partners

Arabidopsis thaliana Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) interaction partners

  1. The transcriptome of overexpressing plants revealed a broad induction of stress-responsive genes not strictly related to the mitochondrial antioxidant machinery, suggesting that overexpression of AtUCP1 imposes a strong stress response within the cell.

  2. Foliar NO3 (-) assimilation was enhanced in both aox1a and ucp1 compared with the wild-type, suggesting that foliar NO3 (-) assimilation is probably driven by a decreased capacity of mAET and an increase in reductant within the cytosol.

  3. Overexpression of UCP1 in the mitochondrial inner membrane induced increased uncoupling respiration, decreased reactive pxygen species accumulation under abiotic stresses, and diminished cellular ATP content.

  4. The main physiological role of UCP1 in Arabidopsis leaves is related to maintaining the redox poise of the mitochondrial electron transport chain to facilitate photosynthetic metabolism. [AtUCP1]

Pig (Porcine) Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) interaction partners

  1. Data indicate that the abundance of uncoupling protein 1 (UCP1) was significantly reduced in the intrauterine growth restriction (IUGR) piglets.

  2. An alignment with human UCP1 revealed that exons 3 to 5 were eliminated by a deletion in the pig sequence.

Human Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) interaction partners

  1. The role of UCP1 gene polymorphisms A-3826G, A-1766G, Met229Leu and Ala64Thr in susceptibility to obesity or metabolic syndrome was reviewed.

  2. Haplotype-based interaction between the PPARGC1A and UCP1 genes is associated with impaired fasting glucose (IFG (show IFNG Proteins)) or type 2 diabetes mellitus (T2DM) among the residents of Henan province, China. Individuals with the haplotype AAG (show MPG Proteins) (PPARGC1A gene) and CTCG (UCP1 gene) have increased susceptibility to IFG (show IFNG Proteins) or T2DM, while those with haplotype AAG (show MPG Proteins) (PPARGC1A gene) and CTCA (UCP1 gene) have a lower risk of IFG (show IFNG Proteins) or T2DM.

  3. human and rodent Brown adipose tissue have similar UCP1 function per mitochondrion.

  4. glucocorticoids increased isoprenaline-stimulated respiration and UCP-1 in human primary brown adipocytes.

  5. These results reveal different characteristics in the biological actions between WAT and BAT (show BAAT Proteins) in obese humans. Increased levels of IL6 (show IL6 Proteins), UCP1 and SIRT1 (show SIRT1 Proteins) in the BAT (show BAAT Proteins) were associated with metabolic parameters improvements.

  6. UCP1 dietary activation can alleviate obesity. (Review)

  7. The molecular features of UCP1 support a conventional mitochondrial carrier-like mechanism. (Review)

  8. The history of discovery of UCP1, the mitochondrial uncoupling protein of brown adipocyte, has been described. (Review)

  9. Transcriptional regulation of the UCP1 protein in obesity and normal thermogenesis has been described. (Review)

  10. The H+ transport mediated by UCP1 was shown to be electrophoretic with a linear relation to the membrane potential. (Review)

Mouse (Murine) Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) interaction partners

  1. through interaction with Zfp516, LSD1 (show KDM1A Proteins) is recruited to UCP1 and other brown adipose tissue-enriched genes.

  2. Together the data show that both UCP1 and UCP3 play essential and complementary roles in thermogenic responses in the mouse and suggest that UCP3-dependent thermogenesis is an under-appreciated mode of thermogenic energy dissipation.

  3. in vitro experiments show that Arrdc3-null adipocytes responded to beta-adrenergic receptor agonist with decreased Ucp1 levels

  4. Despite the absence of UCP1 in the majority of epididymal beige adipocytes, these cells employ prominent creatine cycling as a UCP1-independent thermogenic mechanism.

  5. These novel findings uncover a previously unrecognized metabolic protective role of UCP1 that is independent of its already established role in energy homeostasis/

  6. human and rodent Brown adipose tissue have similar UCP1 function per mitochondrion.

  7. Targeted mitochondrial uncoupling in adipose tissue and skeletal muscle of UCP1-transgenic mice increased substrate metabolism and ameliorates obesity. (Review)

  8. In the absence of regulators (fatty acids, retinoids), rodent UCP1 presents a high ohmic proton conductance that cannot be detected in human UCP1.

  9. The uncoupling of oxidative phosphorylation through a proton conductance pathway across the mitochondrial inner membrane is the mechanism for heat production in brown adipose tissue regulated by UCP1. (Review)

  10. Brown adipocytes trough their unique mitochondrial UCP1 protein burn glucose and lipids to perform thermogenesis in order to survive in cold environments. (Review)

Cow (Bovine) Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) interaction partners

  1. The results of the present study provide an insight into the unexpected expression of Ucp1 in bovine skeletal muscle, which suggests the necessity for further studies on Ucp1-mediated energy expenditure in bovine skeletal muscle.

  2. study suggests that uncoupling protein 1 affects milk yield, milk fat percentage and milk protein (show CSN2 Proteins) percentage

  3. UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 or UCP2 (show UCP2 Proteins) does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro.

  4. These results suggest that CIDE-A (show CIDEA Proteins) and UCP1 are regulated by insulin (show INS Proteins) and/or fatty acids in mammary epithelial cells and lactating mammary glands, and thereby play an important role in lipid and energy metabolism.

UCP1 Protein Profile

Protein Summary

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.

Alternative names and synonyms associated with UCP1

  • uncoupling family protein PUMP2 (PUMP1)
  • uncoupling protein 1 (mitochondrial, proton carrier) (UCP1)
  • uncoupling protein 1 (UCP1)
  • uncoupling protein 1 (mitochondrial, proton carrier) (ucp1)
  • uncoupling protein 1 (mitochondrial, proton carrier) (Ucp1)
  • AI385626 protein
  • ATPUMP1 protein
  • ATUCP1 protein
  • plant uncoupling mitochondrial protein 1 protein
  • Slc25a7 protein
  • Ucp protein
  • UCP1 protein
  • Ucpa protein
  • Uncp protein

Protein level used designations for UCP1

uncoupling protein 1 (mitochondrial, proton carrier) , uncoupling protein 1 , mitochondrial brown fat uncoupling protein 1 , solute carrier family 25 member 7 , thermogenin , UCP 1 , uncoupling protein 1 UCP1 , uncoupling protein 1, mitochondrial , uncoupling protein, mitochondrial , mitochondrial, proton carrier , Solute carrier family 25 member 7 , Thermogenin

824578 Arabidopsis thaliana
461504 Pan troglodytes
574124 Macaca mulatta
751863 Sus scrofa
100036979 Xenopus laevis
100135179 Xenopus (Silurana) tropicalis
7350 Homo sapiens
403574 Canis lupus familiaris
22227 Mus musculus
24860 Rattus norvegicus
281561 Bos taurus
100328618 Oryctolagus cuniculus
101835783 Mesocricetus auratus
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