ErbB2/Her2 antibody

Catalog No. ABIN920575

This Mouse Monoclonal antibody specifically detects ErbB2/Her2 in WB, IHC (p), IP and IHC (fro). It exhibits reactivity toward Human, Mouse, Rat and Monkey. It has been mentioned in 6+ publications

Quick Overview for ErbB2/Her2 antibody (ABIN920575)

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivity: Human, Mouse, Rat, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This ErbB2/Her2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 3B5

Product Details anti-ErbB2/Her2 Antibody

Characteristics: Tumour marker

Purification: The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.

Isotype: IgG1

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C/-20 °C

References for anti-ErbB2/Her2 antibody (ABIN920575)

Schwechheimer, Läufle, Schmahl, Knödlseder, Fischer, Höfler: "Expression of neu/c-erbB-2 in human brain tumors." in: Human pathology, Vol. 25, Issue 8, pp. 772-80, (1994) (PubMed).

Singleton, Niehans, Gu, Litz, Hagen, Qiu, Kiang, Strickler: "Detection of c-erbB-2 activation in paraffin-embedded tissue by immunohistochemistry." in: Human pathology, Vol. 23, Issue 10, pp. 1141-50, (1992) (PubMed).

De Potter, Quatacker, Maertens, Van Daele, Pauwels, Verhofstede, Eechaute, Roels: "The subcellular localization of the neu protein in human normal and neoplastic cells." in: International journal of cancer. Journal international du cancer, Vol. 44, Issue 6, pp. 969-74, (1990) (PubMed).

van Leeuwen, van de Vijver, Lomans, van Deemter, Jenster, Akiyama, Yamamoto, Nusse: "Mutation of the human neu protein facilitates down-modulation by monoclonal antibodies." in: Oncogene, Vol. 5, Issue 4, pp. 497-503, (1990) (PubMed).

De Potter, Van Daele, Van de Vijver, Pauwels, Maertens, De Boever, Vandekerckhove, Roels: "The expression of the neu oncogene product in breast lesions and in normal fetal and adult human tissues." in: Histopathology, Vol. 15, Issue 4, pp. 351-62, (1989) (PubMed).

van de Vijver, Peterse, Mooi, Wisman, Lomans, Dalesio, Nusse: "Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer." in: The New England journal of medicine, Vol. 319, Issue 19, pp. 1239-45, (1988) (PubMed).

Target Details for ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Alternative Name: Neu-Oncogen / C-Erb B2

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development