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Coro1A represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils trafficking during innate immunity.
the phenotype of T cell-specific Coronin 1a deletion resembles the phenotype observed with conventional (whole body) Coronin 1a knock-out mice. In summary, our findings provide formal proof of the predominant T cell-intrinsic role of Coronin 1A.
phosphorylation of coronin 1 on Thr (show TRH Proteins)(418/424) by cyclin-dependent kinase (show CDK1 Proteins) (CDK) 5 (show CDK5 Proteins) activity was responsible for coronin 1-Galphas (show GNAS Proteins) association and the modulation of cAMP production
Authors report that this mutation induces pleiotropic effects in Coro1A protein, including the exacerbation of Coro1A-dependent actin-binding and -bundling activities.
Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A on PKCtheta (show PRKCQ Proteins); recruitment and function downstream of the TCR leading to NF-kappaB (show NFKB1 Proteins) transactivation.
An essential role for 14-3-3 zeta (show YWHAZ Proteins) in the regulation of macropinocytosis in macrophages upon cytokine stimulation through modulation of the localization of coronin 1.
this work suggests that periods before and after NGF (show NGFB Proteins)-TrkA (show NTRK1 Proteins)-induced Coronin-1 expression (and likely other factors) defines two distinct axon growth states
Absence of coronin 1A is associated with severe combined immunodeficiency (show PRKDC Proteins) in humans, hypomorphic mutations lead to a profound defect in naive T cells, expansion of oligoclonal memory T cells, and susceptibility to Epstein Barr B lymphoproliferation (show FAS Proteins).
Our results indicate that Abp1 (show DBNL Proteins) negatively regulates BCR (show BCR Proteins) signaling by coupling actin remodeling to B (show TDO2 Proteins)-cell contraction and activation of inhibitory signaling molecules
Altered T-cell entry and egress in the absence of Coronin 1A attenuates murine acute graft versus host disease.
It has been shown that WDR26 (show WDR26 Proteins) promotes Rac1 membrane translocation following a Coro1A-like and Coro1A-dependent mechanism.
Our studies demonstrate the importance of intact CORO1A C-terminal domains in thymic egress and T-cell survival, as well as in defense against viral pathogens.
These findings suggest that coronin 1A modulates endothelial cell apoptosis by regulating p38beta (show MAPK11 Proteins) expression and activation.
mutatiions result in abnormal T-cells, severe combined immunodeficiency (show PRKDC Proteins) of an epidermodysplasia verruciformis-human papilloma virus mucocutaneous syndrome with B and NK defects and shortened telomeres
Nox4 (show NOX4 Proteins)-mediated redox regulation of PTP1B (show PTPN1 Proteins) serves as a modulator, in part through coronin-1C (show CORO1C Proteins), of the growth and migration of glioblastoma cells.
Results indicate that Coronin1 proteins are at the center of a regulatory hub that coordinates Rac1 activation, effector exchange, and the F-actin organization state during cell signaling.
show a critical role for F-actin deconstruction in cytotoxic function and immunological secretion and identify Coro1A as its mediator
These results demonstrate that coronin-1a is a novel antibody target for clinically isolated syndrome and multiple sclerosis.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16.
coronin, actin binding protein, 1A
, coronin 1
, coronin 1a
, coronin-like actin binding protein
, coronin-like protein A
, coronin-like protein p57
, tryptophan aspartate-containing coat protein
, actin-binding protein p57
, coronin 1A
, coronin-like protein A (CLIPINA)
, tryptophan aspartate-containing coat protein (TACO)