Browse our Carboxypeptidase B2 (Plasma) Proteins (CPB2)

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Carboxypeptidase B2 (Plasma) Proteins (CPB2)
On are 26 Carboxypeptidase B2 (Plasma) (CPB2) Proteins from 10 different suppliers available. Additionally we are shipping Carboxypeptidase B2 (Plasma) Antibodies (179) and Carboxypeptidase B2 (Plasma) Kits (55) and many more products for this protein. A total of 271 Carboxypeptidase B2 (Plasma) products are currently listed.
1110032P04Rik, 1700120C01Rik, 4930405E17Rik, AI255929, AI325129, Cappb1, CPB1, CPB2, CPbeat2, CPbeta1, CPbeta2, CPR, Cpu, pCPB, TAFI
list all proteins Gene Name GeneID UniProt
CPB2 12345 P47757
CPB2 1361  
CPB2 113936 Q9EQV9

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Carboxypeptidase B2 (Plasma) Proteins (CPB2) by Origin

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Top referenced Carboxypeptidase B2 (Plasma) Proteins

  1. Mouse (Murine) CPB2 Protein expressed in Human Cells - ABIN2008456 : Valnickova, Christensen, Skottrup, Thøgersen, Højrup, Enghild: Post-translational modifications of human thrombin-activatable fibrinolysis inhibitor (TAFI): evidence for a large shift in the isoelectric point and reduced solubility upon activation. in Biochemistry 2006 (PubMed)
    Show all 4 references for 2008456

  2. Human CPB2 Protein expressed in Human Cells - ABIN2004308 : Boffa, Reid, Joo, Nesheim, Koschinsky: Characterization of the gene encoding human TAFI (thrombin-activable fibrinolysis inhibitor; plasma procarboxypeptidase B). in Biochemistry 1999 (PubMed)
    Show all 4 references for 2004308

More Proteins for Carboxypeptidase B2 (Plasma) Interaction Partners

Mouse (Murine) Carboxypeptidase B2 (Plasma) (CPB2) interaction partners

  1. Cpb2-deficient mice had decreased pneumococcal meningitis mortality and attenuated cytokine levels and bacterial outgrowth in the systemic compartment but not in the brain (show CSF2 Proteins)compartment, as compared with wild-type mice.

  2. with strain there was significant PKCepsilon (show PRKCE Proteins) translocation to the Z-disc and co-localization with CapZbeta1 or alpha-actinin (show ACTN1 Proteins), which was quantified on confocal images.

  3. Carboxypeptidase B2 deficiency reveals that complement C3a (show C3 Proteins) limits infection and C5a exacerbates infection in a murine polymicrobial sepsis model.

  4. Combination of TAFI-I and a low dose of rtPA was not as effective as the standard dose of rtPA in treating thromboembolic stroke, while TAFI inhibition alone was not effective at all.

  5. Capping protein-beta (show CAPZB Proteins) knockdown decreases filopodial length, alters filopodial shape, and reduces filopodial dynamics.

  6. In an induced osteoarthritis model, CPB2 knockout mice developed dramatically greater cartilage damage than did wild-type mice, had a greater number of osteophytes, and a greater degree of synovitis.

  7. TAFI deficiency results in accelerated fibrogenesis and increased liver damage in murine models of chronic and acute liver disease, which may be related to increased inflammation.

  8. Actin-capping protein is a novel regulator of microtubule stability that functions by antagonizing mDia1 activity toward actin filaments.

  9. This study suggested that increased expression of TrkB (show NTRK2 Proteins) and Capzb2 accompanies adequate brain reserve in the initial stages of AD pathology.

  10. The unique NFkappaB site in the mouse CPB2 promoter is functional and mediates the upregulation of mouse CPB2 expression by TNFalpha (show TNF Proteins).

Human Carboxypeptidase B2 (Plasma) (CPB2) interaction partners

  1. Plasma levels of TAFI are elevated in patients with chronic thromboembolic pulmonary hypertension and are correlated with resistance to clot (show TXNDC17 Proteins) lysis in those patients.

  2. R12 (show GPR17 Proteins) is a critical residue for the activation of TAFI by thrombin (show F2 Proteins)-thrombomodulin (show THBD Proteins)

  3. Thrombin activatable fibrinolysis inhibitor, particularly its preoperative levels but also levels during the immediate postoperative period, may be key for understanding coagulopathy during liver transplantation, and it may have a role as predictor of increased mortality rates in the liver transplant population

  4. The results suggest that although the TAFI S438G>T polymorphism is not correlated with venous thrombosis risk in all genetic models of venous thrombosis, a trend toward a reduced risk still could be observed. (Meta-analysis)

  5. The results of the present study demonstrated that the CPB2 expression in patients with chronic hepatitis C was inversely correlated with several risk factors of hepatic fibrosis or steatosis, although ectopic CPB2 expression did not suppress the expression of fibrogenic or lipogenic genes.

  6. Protein C and TAFI are concurrently activated in a thrombomoulin-dependent manner and do not compete for the thrombin (show F2 Proteins)-TM complex, raising the possibility that they interact with distinct activation complexes.

  7. Acute myocardial infarction patients have higher plasma CPU levels and lower proCPU levels than controls. This finding indicates in vivo generation of functional active CPU in patients with AMI (show CFD Proteins).

  8. Arg12-Glu28 and Cys383-Val401 in TAFI are involved in thrombomodulin (show THBD Proteins)-mediated TAFI activation. Gly205-Asp232 is involved in binding to thrombin (show F2 Proteins).

  9. CPB2 polymorphisms (reference sequences: rs1926447 and rs3742264) were related to systemic complications in bacterial meningitis. TAFI levels correlated positively with CSF (show CSF2 Proteins) complement. rs1926447 (TT) was associated with higher levels of TAFI in CSF (show CSF2 Proteins).

  10. Pro-inflammatory cytokines or lipopolysaccharide decreased TAFI protein levels via binding of tristetraprolin to the CPB2 3'-UTR, which mediates CPB2 mRNA destabilisation. HuR can bind the CBP2 3'UTR. This is reduced by pro-inflammatory mediators.

Cow (Bovine) Carboxypeptidase B2 (Plasma) (CPB2) interaction partners

  1. analysis of the crystal structure of thrombin-activable fibrinolysis inhibitor (TAFI) and description of the structural basis for its intrinsic activity and the short half-life of TAFIa

  2. Purified bovine TAFI activated in the presence of a proteinaceous inhibitor renders a stable enzyme-inhibitor complex.

  3. Findings presented here suggest that the properties of these two orthologous proteins are similar and that conclusions reached using the bovine TAFI may be extrapolated to the human TAFI protein.

Carboxypeptidase B2 (Plasma) (CPB2) Protein Profile

Protein Summary

Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region.

Alternative names and synonyms associated with Carboxypeptidase B2 (Plasma) (CPB2)

  • capping protein (actin filament) muscle Z-line, beta (Capzb)
  • carboxypeptidase B2 (plasma) (CPB2)
  • carboxypeptidase B2 (plasma) (Cpb2)
  • 1110032P04Rik protein
  • 1700120C01Rik protein
  • 4930405E17Rik protein
  • AI255929 protein
  • AI325129 protein
  • Cappb1 protein
  • CPB1 protein
  • CPB2 protein
  • CPbeat2 protein
  • CPbeta1 protein
  • CPbeta2 protein
  • CPR protein
  • Cpu protein
  • pCPB protein
  • TAFI protein

Protein level used designations for CPB2

F-actin-capping protein subunit beta , capZ beta , capping protein beta 1 , carboxypeptidase B-like protein , carboxypeptidase B2 , carboxypeptidase B2 (plasma, carboxypeptidase U) , carboxypeptidase R , thrombin-activable fibrinolysis inhibitor , thrombin-activatable fibrinolysis inhibitor , carboxypeptidase U , CPR , CPU , TAFI , plasma carboxypeptidase B

12345 Mus musculus
1361 Homo sapiens
56373 Mus musculus
608910 Canis lupus familiaris
113936 Rattus norvegicus
508222 Bos taurus
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