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Mammalian Monoclonal DLG1 Primary Antibody for ISt, IHC - ABIN1304943
Jafari, Esmaili, Toufan, Aghamollaei: Bilingual proficiency and cognitive reserve in Persian-English bilingual older adults. in Aging clinical and experimental research 2015
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Human Monoclonal DLG1 Primary Antibody for ICC, IF - ABIN4305323
Cui, Hayashi, Sun, Belmares, Cobey, Phan, Schweizer, Salter, Wang, Tasker, Garman, Rabinowitz, Lu, Tymianski: PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Show all 6 Pubmed References
Human Monoclonal DLG1 Primary Antibody for IF, IP - ABIN968224
Adey, Huang, Ormonde, Baumgard, Pero, Byreddy, Tavtigian, Bartel: Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding. in Cancer research 2000
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Human Monoclonal DLG1 Primary Antibody for IF, IP - ABIN968225
Caruana, Bernstein: Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene. in Molecular and cellular biology 2001
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Rat (Rattus) Polyclonal DLG1 Primary Antibody for WB - ABIN1742275
Smalla, Sahin, Putzke, Tischmeyer, Gundelfinger, Kreutz: Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis. in Neurochemical research 2009
Human Polyclonal DLG1 Primary Antibody for ELISA, WB - ABIN451674
Mahoney, Sammut, Xavier, Cunningham, Go, Brim, Stappenbeck, Miner, Swat: Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. in Proceedings of the National Academy of Sciences of the United States of America 2006
Human Polyclonal DLG1 Primary Antibody for ICC, IF - ABIN269417
Gardner, Naren, Bahouth et al.: Assembly of an SAP97-AKAP79-cAMP-dependent protein kinase scaffold at the type 1 PSD-95/DLG/ZO1 motif of the human beta(1)-adrenergic receptor generates a receptosome involved in receptor recycling ... in The Journal of biological chemistry 2007
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Adrenergic modulation of Kv1.1 (show KCNA2 Antibodies) was mediated by the signaling scaffold SAP97, which, through direct protein-protein interactions, escorts beta2 signaling to remove Kv1.1 (show KCNA2 Antibodies) from the dendrite surface. This process promoted spike timing-dependent long-term synaptic potentiation at mouse hippocampal excitatory synapses.
that Pten (show PTEN Antibodies), through the Dlg1-binding ability of its PDZ (show INADL Antibodies)-binding domain , accumulates phosphorylated Eg5 (show KIF11 Antibodies) at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes
Kif13b (show KIF13B Antibodies) also negatively regulates Dlg1 stability in oligodendrocytes, in which Dlg1, in contrast to Schwann cells, enhances AKT (show AKT1 Antibodies) activation and promotes myelination
Dlg1 regulates p38 (show CRK Antibodies)-dependent proinflammatory cytokine production.
phenotypes of Dlg1-/- mice involving cellular disorganization and insufficient tissue elongation strongly suggest a defect in the convergent extension movements
Loss of Dlg1 confers strong predisposition to the development of pediatric B-ALL in a murine model.
data indicate that the surface expression and function of EAAT2b can be rapidly modulated through the disruption of its interaction with DLG1 by CaMKII (show CAMK2G Antibodies) activation.
Loss of Dlg-1 in the mouse lens impairs fibroblast growth factor receptor signaling.
lack of the Dlg1 gene induces a decrease in apoptotic epithelial cell death and the persistence of the common nephric duct, which result in a dysfunctional vesicoureteral junction and cause megaureter or hydronephrosis through vesicoureteral reflux
DLG1 influences distal ureter maturation via a non-epithelial cell autonomous mechanism involving reduced retinoic acid signaling, Ret (show RET Antibodies) expression, and apoptosis.
Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 (show DISC1 Antibodies) contribute to maintaining Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta (show GSK3b Antibodies) phosphorylation.
Results suggest that discs large (show DLG4 Antibodies) tumour suppressor (DLG1) expression may have an important role in the progression of early dysplastic cervical lesions, giving prognostic information.
Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia was identified.
Human papillomavirus oncoproteins E6 and E7 induce the loss of DLG1 from the cell borders and an increase in the level of DLG1 protein, reflecting the pattern observed in cervical lesions.
The study provides new evidence for understanding the transcriptional regulation of DLG1 and the changes in DLG1 expression during different biological processes.
Trans-homophilic interaction of CADM1 (show CADM1 Antibodies) activates PI3K (show PIK3CA Antibodies) by forming a complex with MAGuK-family proteins MPP3 (show MPP3 Antibodies) and Dlg (show DLG4 Antibodies).
the synapse-associated protein-97 (SAP97), an excitatory synapse scaffolding element, governs ADAM10 (show ADAM10 Antibodies) trafficking from dendritic Golgi outposts to synaptic membranes, mediated by a previously uncharacterized protein kinase C (show PKC Antibodies).
E4-ORF1 (show NCKIPSD Antibodies) interacts with Dlg1 and PI3K (show PIK3CA Antibodies) to assemble a ternary complex where E4-ORF1 (show NCKIPSD Antibodies) hijacks the Dlg1 oncogenic function to relocate cytoplasmic PI3K (show PIK3CA Antibodies) to the membrane for constitutive activation.
While other domains of SAP97 were involved in forward trafficking of GluN1 (show GRIN1 Antibodies)-3 out of the endoplasmic reticulum (ER), the SH3 domain (show ITSN1 Antibodies) was necessary and sufficient to block the ER retention.
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.
discs, large homolog 1 (Drosophila)
, synapse-associated protein 97
, disks large homolog 1
, Drosophila discs-large tumor suppressor homologue (synapse associated protein)
, embryo-dlg/synapse-associated protein 97
, presynaptic protein SAP97