Browse our Slit Homolog 2 (Drosophila) Proteins (SLIT2)

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Slit Homolog 2 (Drosophila) Proteins (SLIT2)
On are 11 Slit Homolog 2 (Drosophila) (SLIT2) Proteins from 5 different suppliers available. Additionally we are shipping Slit Homolog 2 (Drosophila) Antibodies (84) and Slit Homolog 2 (Drosophila) Kits (17) and many more products for this protein. A total of 114 Slit Homolog 2 (Drosophila) products are currently listed.
Drad-1, E030015M03Rik, E130320P19Rik, mKIAA4141, Slil3, Slit, Slit-2, slit2-a
list all proteins Gene Name GeneID UniProt
SLIT2 9353 O94813
SLIT2 20563 Q9R1B9
SLIT2 360272  

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Slit Homolog 2 (Drosophila) Proteins (SLIT2) by Origin

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More Proteins for Slit Homolog 2 (Drosophila) Interaction Partners

Zebrafish Slit Homolog 2 (Drosophila) (SLIT2) interaction partners

  1. These data supports a model whereby Wnt signaling through Frizzled-3a attenuates expression of Slit2 in the rostral midline of the forebrain.

  2. In embryonic axon tracts, Robo2 (show ROBO2 Proteins) responds to signals from slit2 and slit3 (show SLIT3 Proteins).

  3. Data show that Hedgehog (show SHH Proteins) signaling is required for commissure formation, glial bridge formation, and the restricted expression of the guidance molecules slit1a, slit2, slit3 (show SLIT3 Proteins) and sema3d (show SEMA3D Proteins).

Xenopus laevis Slit Homolog 2 (Drosophila) (SLIT2) interaction partners

  1. Slit acts via Robo2 (show ROBO2 Proteins) in dendrites as a branching/growth factor but not in guidance, while Robo2 (show ROBO2 Proteins) and Robo3 (show ROBO3 Proteins) function in concert in axons to mediate axonal interactions and respond to Slits as guidance factors

Human Slit Homolog 2 (Drosophila) (SLIT2) interaction partners

  1. human placental multipotent mesenchymal stromal cell express Slit2 (show SLIT3 Proteins) and both Robo1 (show ROBO1 Proteins) and Robo4 (show ROBO4 Proteins) are present in human umbilical vein endothelial cells.

  2. Slit2 (show SLIT3 Proteins)-Robo1 (show ROBO1 Proteins) signaling promoted the adhesion, invasion and migration of tongue carcinoma cells by upregulating the expression levels of MMP2 (show MMP2 Proteins) and MMP9 (show MMP9 Proteins) and, downregulating the expression of E-cadherin (show CDH1 Proteins).

  3. findings suggest that AK3 and SLIT2 may be potential candidates involved in genetic susceptibility to colorectal cancer

  4. Low Slit2 expression is associated with glioma.

  5. Results indicate the importance of SLIT2 (show SLIT3 Proteins)-ROBO1 (show ROBO1 Proteins)-CDC42 (show CDC42 Proteins) signaling pathway in predicting tumor progression.

  6. We postulate that Robo1 (show ROBO1 Proteins) promotes tumor invasion partly by the upregulation of MMP2 (show MMP2 Proteins) after activation of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway. Notably, Slit2 (show SLIT3 Proteins) knockdown caused the upregulation of Robo1 (show ROBO1 Proteins) expression both at the mRNA and protein levels. Thus, the stimulatory effects of Slit2 (show SLIT3 Proteins) knockdown on tumor progression can be ascribed, at least in part, to the upregulation of Robo1 (show ROBO1 Proteins) and its positive role in tumor progression.

  7. expression of the evolutionarily conserved slit2 (show SLIT3 Proteins) Gene Promoter Requires Sp1 (show PSG1 Proteins)

  8. Study shows that Slit2 (show SLIT3 Proteins) mRNA and protein levels were significantly reduced in papillary thyroid cancer (PTC (show F9 Proteins)) specimens and implicates Slit2 (show SLIT3 Proteins) functions as a negative regulator in the development and progression of PTC (show F9 Proteins).

  9. Overexpression of Slit2 induces its tumor suppressive effects in Breast cancer.

  10. Significantly increased serum Slit2 (show SLIT3 Proteins) levels and hepatic expression of Slit2 (show SLIT3 Proteins) and Robo1 (show ROBO1 Proteins) were observed in patients with liver fibrosis.

Mouse (Murine) Slit Homolog 2 (Drosophila) (SLIT2) interaction partners

  1. Transgenic over-expression of slit2 enhances disruption of blood-brain barrier and increases cell death after traumatic brain injury in mice. This suggest that over expression of slit2 plays a detrimental role in the pathophysiology of mild TBI (show TBPL1 Proteins).

  2. Slit2 induces a robust activation of PKA signaling, which is required for its prothermogenic activity.

  3. Robo1-Slit2 interaction required for pathfinding mechanism essential to establish the functionally important habenulo-interpeduncular connection.

  4. Together, these observations suggest that Slit2 serves as a factor utilized by muscle Ctnnb1 (show CTNNB1 Proteins) to direct presynaptic differentiation.

  5. Slit2 acts as a repellant cue to mediate axon guidance in the formation of the anterior commissure.

  6. Slit2/Robo1 (show ROBO1 Proteins) signaling promotes intestinal tumorigenesis through Src (show SRC Proteins)-mediated activation of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.

  7. the two genes neuropeptide Y (Npy (show NPY Proteins)) and Slit homolog 2 (Drosophila) (Slit2) gradually increase during aging, and upon suppression of these two genes

  8. Data shows that modulation of angiostatic factor Slit2 by EphA2 receptor regulates endothelial responses to VEGF-mediated angiogenesis and tumor neovascularization.

  9. administration of Slit2 to atherosclerosis-prone LDL receptor (show LDLR Proteins)-deficient mice inhibited monocyte recruitment to nascent atherosclerotic lesions.

  10. Results provide novel evidence that low expression of SLIT2 correlates with poor prognosis and promotes metastasis in ESCC, which may be regulated by the Cdc42 (show CDC42 Proteins)-mediated pathways.

Slit Homolog 2 (Drosophila) (SLIT2) Protein Profile

Protein Summary

acts as a ligand for glypican-1, a heparan sulfate proteoglycan\; may play a role in neurogenesis and midline development

Alternative names and synonyms associated with Slit Homolog 2 (Drosophila) (SLIT2)

  • slit (Drosophila) homolog 2 (slit2)
  • slit homolog 2 (slit2)
  • slit homolog 2 (Drosophila) (SLIT2)
  • slit homolog 2 (Drosophila) (Slit2)
  • Drad-1 protein
  • E030015M03Rik protein
  • E130320P19Rik protein
  • mKIAA4141 protein
  • Slil3 protein
  • Slit protein
  • Slit-2 protein
  • slit2-a protein

Protein level used designations for SLIT2

slit homolog 2 protein , slit-2 , downregulated during adipocyte differentiation-1 , neurogenic extracellular slit protein

80353 Danio rerio
394404 Xenopus laevis
9353 Homo sapiens
373967 Gallus gallus
534164 Bos taurus
20563 Mus musculus
360272 Rattus norvegicus
595148 Canis lupus familiaris
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