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Tmod3 is a novel Akt2 (show AKT2 Proteins) effector that mediates insulin (show INS Proteins)-induced cortical actin remodelling and subsequent GLUT4 (show SLC2A4 Proteins) membrane insertion
Loss of TMOD3 is associated with hemorrhage, defect in actin polymerization, organization and platelet biogenesis.
Tmod1 (show TMOD1 Proteins) and Tmod3 showed somewhat different tropomyosin (show TPM2 Proteins)-binding site utilization.
Tmod3-/- embryos are defective in definitive erythropoiesis with reduced progenitors, impaired terminal differentiation, and enucleation.
Western blots of Tmod1 (show TMOD1 Proteins)-null RBCs (show SSU1 Proteins) confirm the absence of Tmod1 (show TMOD1 Proteins) and show the presence of Tmod3, which is normally not present in RBCs (show SSU1 Proteins).
Tmod3 and -4 localize to pointed ends in Tmod1 (show TMOD1 Proteins)-null adult muscle
study has identified several new proteins like RHOC (show RHOC Proteins), DLG5 (show DLG5 Proteins), UGDH (show UGDH Proteins), TMOD3 in addition to known chemoresistance associated proteins in non-small cell lung carcinoma.
investigation of biomarkers for early diagnosis of endometriosis: Data suggest that TMOD3, tropomyosin 3, and stomatin-like protein 2 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified.
capping of actin filament pointed ends by Tmod3 inhibits cell migration and reveal a novel control mechanism for regulation of actin filaments in lamellipodia.
levels of TM1 (show TPM2 Proteins), TM2 (show TPM2 Proteins) and TM3 (show TPM1 Proteins) are reduced in human transitional cell carcinoma cells, but significantly upregulated by inhibition of the mitogen-activated protein kinase (show MAPK1 Proteins)-signaling pathway
the Tmod3 isoform may regulate actin dynamics differently in cells than the previously described tropomodulin isoforms
findings show that the pointed-end capping protein Tmod3 contributes to epithelial cell shape within confluent monolayers of polarized epithelial cells
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).
tropomodulin 3 (ubiquitous)
, tropomodulin 3
, tropomodulin 3; ubiquitous tropomodulin
, ubiquitous tropomodulin
, ubiquitous tropomodulin U-Tmod