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ARPP-19 is validated by showing reduced mRNA and protein levels when miR (show MLXIP Proteins)-320 is overexpressed in neurites.
Data show that micrRNA miR-320a directly targets cAMP-regulated phosphoprotein 19 (ARPP-19) and estrogen-related receptor gamma protein (ERRgamma) in breast cancer cell lines.
ARPP-19 may play a role in HCC (show FAM126A Proteins) pathogenesis through regulating cell proliferation.
ARPP19 gene expression is decreased in follicular variant of papillary thyroid carcinoma.
Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease.
PP2A (show PPP2R2B Proteins)-B55delta, Greatwall (show MASTL Proteins) and ARPP19 are not only required for entry into meiotic divisions, but are also pivotal effectors within the Cdk1 (show CDK1 Proteins) auto-regulatory loop responsible for its independence with respect to the PKA-negative control.
description of how Gwl (show MASTL Proteins) activation results in PP2A (show PPP2R2B Proteins) inhibition; Arpp19 and alpha-Endosulfine (show ENSA Proteins) when phosphorylated by Gwl (show MASTL Proteins) associate with and inhibit PP2A (show PPP2R2B Proteins) promoting mitotic entry; endogenous Arpp19 responsible for PP2A (show PPP2R2B Proteins) inhibition at mitotic entry in egg extracts
study identifes Ensa (show ENSA Proteins) and Arpp-19 as phosphorylation-dependent inhibitors of PP2A (show PPP2R2B Proteins)-B55delta and physiological substrates of Greatwall (show MASTL Proteins) kinase
The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A\; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010
cAMP-regulated phosphoprotein 19
, cAMP-regulated phosphoprotein ARPP-19
, cyclic AMP phosphoprotein, 19 kDa
, cyclic AMP phosphoprotein, 19kD
, cyclic AMP phosphoprotein, 19 kD
, cAMP-regulated phosphoprotein 19-A