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Early Growth Response 1 Proteins (EGR1)
On www.antibodies-online.com are 19 Early Growth Response 1 (EGR1) Proteins from 7 different suppliers available. Additionally we are shipping EGR1 Antibodies (132) and EGR1 Kits (45) and many more products for this protein. A total of 204 EGR1 products are currently listed.
Synonyms:
A530045N19Rik, at225, egr, egr-1, EGR-1-A, EGR1, ETR103, g0s30, Krox-1, krox-24, krox24, Ngf1, NGF1-A, Ngfi, ngfi-a, NGFIA, tis8, wu:fj64b05, wu:fq25f01, Xegr-1, zenk, Zfp-6, zif-268, Zif268, znf225
list all proteins Gene Name GeneID UniProt
EGR1 1958 P18146
EGR1 13653 P08046
EGR1 24330 P08154

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EGR1 Proteins (EGR1) by Origin

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Pig (Porcine) Early Growth Response 1 (EGR1) interaction partners

  1. Egr-1 silencing through intracoronary delivery of a targeting DNAzyme at the time of reperfusion following acute myocardial ischemia decreases myocardial inflammation and apoptosis leading to improved cardiac function.

  2. Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion.

  3. Data suggest that Egr-1 protein levels may be tightly regulated in an attempt to diminish neurotoxicity or to enhance plasticity in newborn animals.

Human Early Growth Response 1 (EGR1) interaction partners

  1. The Egr-1 is essential for CSE-induced MUC5AC production in HBE (show HBe1 Proteins) cells likely through interaction with and modulation of AP-1 (show FOSB Proteins), and re-emphasize targeting Egr-1 as a novel therapeutic strategy for COPD (show ARCN1 Proteins).

  2. Finally, the authors show that EGFR (show EGFR Proteins)-ERK1/2 and beta1-integrin signaling are the main pathways used for bacteria-mediated EGR1 upregulation.

  3. Early growth response (Egr)-1 is essential for fibrotic responses to Transforming growth factor (TGF)-beta (show TGFB1 Proteins). Egr-1 mediates TGF-beta1 (show TGFB1 Proteins)-induced COL1A1 (show COL1A1 Proteins) and COL1A2 (show COL1A2 Proteins) mRNA expression and acid-soluble collagen production in buccal mucosal fibroblasts (BMFs).The epigallocatechin-3-gallate (EGCG) can block TGF-beta1 (show TGFB1 Proteins)-induced collagen production by attenuating Egr-1 expression in BMFs.

  4. Along with the reduction of ovarian cancer-2/disabled homolog 2 (DOC-2 (show DAB2 Proteins)/DAB2) interactive protein (DAB2IP (show DAB2IP Proteins)) expression, EGR-1 gene was upregulated in FI-treated cells. On the other hand, downregulation of EGR-1 gene expression sensitized radioresistant cells to IR accompanied by DAB2IP (show DAB2IP Proteins) overexpression and STAT3 (show STAT3 Proteins) inactivation. In addition, NF-kappaB (show NFKB1 Proteins) inhibitor, BAY11-7082 enhanced resistant cells' radiosensitivity and chemos...

  5. ROS (show ROS1 Proteins) activation of the MAPK (ERK (show MAPK1 Proteins)-1 (show MAPK3 Proteins)/2)/Egr-1 pathway is a main player in the regulatory mechanism for cigarette smoke extract-induced PlGF (show PGF Proteins) production. Antioxidants could partly abolish these effects.

  6. adipose tissue-derived mesenchymal stem cells (AT-MSCs) from diabetic patients may contribute to microvascular damage and delay wound healing through the overexpression of EGR-1.

  7. KLF12 (show KLF12 Proteins) promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 (show KLF12 Proteins) and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 (show KLF12 Proteins) likely plays an important role in CRC (show CALR Proteins) and could serve as a potential prognostic marker and therapeutic target.

  8. Shikonin induces apoptosis in some lung cancer cells via activation of FOXO3a (show FOXO3 Proteins)/EGR1/SIRT1 (show SIRT1 Proteins) signaling, and AKT (show AKT1 Proteins) and p300 (show EP300 Proteins) negatively regulate this process via Bim (show BCL2L11 Proteins) upregulation.

  9. Inhibition of mTORC1-mediated 4EBP1 (show EIF4EBP1 Proteins) phosphorylation leads to decreased expression of c-MYC (show MYC Proteins) and subsequent upregulation of the proapoptotic BCL2 (show BCL2 Proteins) family member PUMA (show BBC3 Proteins), whereas inhibition of mTORC2 (show CRTC2 Proteins) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 (show BCL2L11 Proteins) locus encoding BIM (show BCL2L11 Proteins).

  10. Conversely, siRNA-mediated Klotho (show KL Proteins) silencing up-regulated Egr-1, FN, and Col (show HDAC1 Proteins) I expression and the p-Smad3/Smad3 (show SMAD3 Proteins) ratio. Moreover, the effects of si-Klotho (show KL Proteins) on Egr-1 expression were abolished by the TGF-beta1 (show TGFB1 Proteins) inhibitor SB-431542. Klotho (show KL Proteins) overexpression can prevent mesangial ECM (show MMRN1 Proteins) production in high-glucose-treated human MCs (show SMCP Proteins), an effect that has been partially attributed to Egr-1 down-regulation facilitated by TGF-beta1 (show TGFB1 Proteins)/Smad3 (show SMAD3 Proteins) s...

Cow (Bovine) Early Growth Response 1 (EGR1) interaction partners

  1. Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.

  2. The authors conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells.

  3. EGR-1's expression prior to ovulation and its stimulating effect on the expression of genes known to be involved in prostaglandin biosynthesis pathway, suggest its potential involvement in the regulation of preovulatory events in cattle.

Mouse (Murine) Early Growth Response 1 (EGR1) interaction partners

  1. Herein, we report that silencing of Egr-1 in the hippocampus by shRNA reduces tau phosphorylation, lowers amyloid-beta (Abeta (show APP Proteins)) pathology, and improves cognition in the 3xTg-Alzheimer disease mouse model.

  2. Egr-1 is a novel regulator of drebrin (show DBN1 Proteins) expression, which is linked to changes in dendritic spine density

  3. In the present study, we have investigated the contribution of element C to Krox20 (show EGR2 Proteins) expression, as it was the only characterized initiator element with an activity in r3. Using a conditional knock-out mutation of element C, we show that, unexpectedly, this element is not necessary for Krox20 (show EGR2 Proteins) initial expression in r3.

  4. HAS2 (show HAS2 Proteins)-produced hyaluronan is required for CD44V6 and TGFbetaRI co-localization and subsequent CD44V6/ERK1 (show MAPK3 Proteins)/EGR1 signaling. These results demonstrate a novel positive-feedback loop that links the myofibroblast phenotype to TGFbeta1 (show TGFB1 Proteins)-stimulated CD44V6/ERK (show EPHB2 Proteins)/EGR1 signaling.

  5. Egr1 expression is sensitive to mechanical signals in tendon cells.

  6. age-related up-regulation of EGR1 promotes granulosa cell apoptosis in follicle atresia during ovarian aging.

  7. data indicate that Egr-1 promotes Abeta (show APP Proteins) synthesis via transcriptional activation of BACE-1 (show BACE Proteins) and suggest that Egr-1 plays role in activation of BACE-1 (show BACE Proteins) and acceleration of Abeta (show APP Proteins) synthesis in AD brain.

  8. EGR1, an early growth response factor, is a critical transcription factor that regulates the hepatic clock circuit.

  9. EGR1(-/-) mouse embryonic fibroblasts demonstrated lower susceptibility to Venezuelan equine encephalitis virus-induced cell death than isogenic wild-type fibroblasts, indicating that EGR1 modulates proapoptotic pathways following virus infection.

  10. The levels of B23 (show NPM1 Proteins) expression are directly regulated by EGR1.

Zebrafish Early Growth Response 1 (EGR1) interaction partners

  1. egr1 colocalizes with tyrosine hydroxylase (show TH Proteins) in the olfactory bulb throughout brain development.

  2. successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish

  3. The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization

  4. Egr1 gene has important role in zebrafish embryonic oculogenesis. Lens and retina with egr1 gene deletion were primitive and lacked differentiation. Such arrested retinal and lenticular development in Egr1 morphants resulted in microphthalmos.

Rabbit Early Growth Response 1 (EGR1) interaction partners

  1. Gene therapy using in vivo transfection of an Egr-1 decoy ODN significantly inhibits proliferation of VSMC and intimal hyperplasia of vein grafts in a rabbit model.

  2. Results show that EGR1 plays a key role in tendon formation, healing, and repair through BMP12 (show GDF7 Proteins)/Smad1 (show SMAD1 Proteins)/5/8 pathway.

  3. Collectively, these results demonstrate that Egr-1 is expressed rapidly upon HSV-1 infection and that this novel induction could be due to the NFsmall ka, CyrillicB/CREB (show CREB1 Proteins)-mediated transactivation.

EGR1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.

Alternative names and synonyms associated with EGR1

  • early growth response protein 1(Egr-1, NGFI-A) (EGR-1)
  • early growth response protein 1 (egr-1) (CNK00890)
  • early growth response 1 (EGR1)
  • early growth response 1 (Egr1)
  • early growth response 1 (egr1)
  • early growth response 1 (egr1-a)
  • early growth response protein 1 (EGR-1)
  • A530045N19Rik protein
  • at225 protein
  • egr protein
  • egr-1 protein
  • EGR-1-A protein
  • EGR1 protein
  • ETR103 protein
  • g0s30 protein
  • Krox-1 protein
  • krox-24 protein
  • krox24 protein
  • Ngf1 protein
  • NGF1-A protein
  • Ngfi protein
  • ngfi-a protein
  • NGFIA protein
  • tis8 protein
  • wu:fj64b05 protein
  • wu:fq25f01 protein
  • Xegr-1 protein
  • zenk protein
  • Zfp-6 protein
  • zif-268 protein
  • Zif268 protein
  • znf225 protein

Protein level used designations for Early Growth Response 1 Proteins (EGR1)

early growth response protein 1(Egr-1, NGFI-A) , early growth response protein 1 (egr-1) , early growth response 1 , EGR-1 , early growth response protein 1 , nerve growth factor-induced protein A , transcription factor ETR103 , transcription factor Zif268 , zinc finger protein 225 , zinc finger protein Krox-24 , Krox-24 nuclear protein , zinc finger protein ZENK , etID309970.14 , zinc-finger transcriptional protein , early growth response protein 1-A

GENE ID SPECIES
397332 Sus scrofa
3254484 Cryptococcus neoformans var. neoformans JEC21
100618969 Monodelphis domestica
1958 Homo sapiens
481528 Canis lupus familiaris
407125 Bos taurus
13653 Mus musculus
24330 Rattus norvegicus
462097 Pan troglodytes
100716298 Cavia porcellus
100520726 Sus scrofa
373931 Gallus gallus
443547 Ovis aries
30498 Danio rerio
100008579 Taeniopygia guttata
399162 Xenopus laevis
100009491 Oryctolagus cuniculus
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