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Browse our ENPP1 Proteins (ENPP1)

Full name:
Ectonucleotide Pyrophosphatase/phosphodiesterase 1 Proteins (ENPP1)
On are 16 Ectonucleotide Pyrophosphatase/phosphodiesterase 1 (ENPP1) Proteins from 5 different suppliers available. Additionally we are shipping ENPP1 Antibodies (138) and ENPP1 Kits (17) and many more products for this protein. A total of 174 ENPP1 products are currently listed.
4833416E15Rik, AI428932, ARHR2, C76301, CD203c, E-NPP1, ENPP1, Ly-41, M6S1, NPP1, Npps, PC-1, Pc1, Pca, Pca-1, PCA1, Pdnp1, si:ch211-142e24.2, ttw, twy, zgc:136238
list all proteins Gene Name GeneID UniProt
ENPP1 5167 P22413
ENPP1 18605  
ENPP1 85496 Q924C3

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ENPP1 Proteins (ENPP1) by Origin

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More Proteins for ENPP1 Interaction Partners

Zebrafish Ectonucleotide Pyrophosphatase/phosphodiesterase 1 (ENPP1) interaction partners

  1. enpp1 can exert its function in tissues that are remote from its site of expression.

Human Ectonucleotide Pyrophosphatase/phosphodiesterase 1 (ENPP1) interaction partners

  1. Results suggest that heterozygous mutations in the SMB domains of ENPP1 are necessary, but not always sufficient in themselves to cause Cole disease.

  2. The K121Q polymorphism of ENPP1 shows no direct correlation with metabolic syndrome in Han Chinese.

  3. Our findings demonstrate that ENPP1, TCF7L2 (show TCF7L2 Proteins), and FTO (show FTO Proteins) may predispose to T2DM in the mixed-ancestry population.

  4. In this exploratory analysis, IRS1 (show IRS1 Proteins), ENNP1 and TRIB3 (show TRIB3 Proteins), known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin (show INS Proteins) signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes.

  5. we found that patients with severe asthma exacerbation had reduced activity of leukocyte ectonucleotidases and reduced expression of E-NPP1 in PMNs.

  6. A rare type of idiopathic infantile arterial calcification resulting from a mutation in the gene encoding for the ENPP1 enzyme.

  7. Loss of function mutation in ENPP1 is associated with early onset hearing loss in autosomal recessive hypophosphatemic rickets.

  8. ENPP1 was also identified as a substrate of the 26S proteasome (show Psmd4 Proteins), the activity of which is downregulated in CSCs

  9. Expression of NPP1 and 5'-nucleotidase (show NT5E Proteins) by valve interstitial cells promotes the mineralization of the aortic valve through A2aR (show ADORA2A Proteins) and a cAMP/PKA/CREB (show CREB1 Proteins) pathway.

  10. ENPP1 rs1805101 polymorphism is associated with Insulin (show INS Proteins) resistance and advanced Diabetic nephropathy.

Mouse (Murine) Ectonucleotide Pyrophosphatase/phosphodiesterase 1 (ENPP1) interaction partners

  1. Vitamin D3 regulates Enpp1 expression, which presumably, in the context of adequate tissue non-specific alkaline phosphatase activity, provides phosphate to stimulate mineralisation.

  2. ENPP1-Fc fusion protein prevents the mortality, vascular calcifications and sequela of disease in mouse models of generalized arterial calcification of infancy.

  3. Expression of NPP1 and 5'-nucleotidase (show ACPP Proteins) by valve interstitial cells promotes the mineralization of the aortic valve through A2aR (show ADORA2A Proteins) and a cAMP/PKA/CREB (show CREB1 Proteins) pathway.

  4. Increased NPP1 expression and activity might contribute to the decreased mineralisation observed when osteoblasts are exposed to acid conditions.

  5. NPP1 has a role in obesity and diabetes in a mouse model

  6. we have characterized the phenotypic and histopathologic features of this spontaneous mutant mouse, designated as asj (show ARSJ Proteins)-2J, and we have identified a large deletion/insertion mutation in the Enpp1 gene

  7. these data highlight the key role of NPP1 in regulating calcification of both soft and skeletal tissues.

  8. ENPP1 2'3'-cGAMP-hydrolyzing activity is repsonsible for tumor progression in humans and mice.

  9. Both mono-allelic and bi-allelic ENPP1 deficiency promote dysregulated VSMC function, with robust C/EBP homologous protein (show DDIT3 Proteins) expression and enhanced neointimal hyperplasia after injury in vivo, but marked post-injury calcification limited to Enpp1-/- mice.

  10. Studied the role of genetic modulation and the role of diet in nephrocalcinosis using two established mouse models of ectopic mineralization, Abcc6 (show ABCC6 Proteins)(tm1Jfk) and Enpp1(asj (show ARSJ Proteins)) mice.

ENPP1 Protein Profile

Protein Summary

This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.

Alternative names and synonyms associated with ENPP1

  • ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1)
  • ectonucleotide pyrophosphatase/phosphodiesterase 1 (enpp1)
  • ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1)
  • 4833416E15Rik protein
  • AI428932 protein
  • ARHR2 protein
  • C76301 protein
  • CD203c protein
  • E-NPP1 protein
  • ENPP1 protein
  • Ly-41 protein
  • M6S1 protein
  • NPP1 protein
  • Npps protein
  • PC-1 protein
  • Pc1 protein
  • Pca protein
  • Pca-1 protein
  • PCA1 protein
  • Pdnp1 protein
  • si:ch211-142e24.2 protein
  • ttw protein
  • twy protein
  • zgc:136238 protein

Protein level used designations for ENPP1

ectonucleotide pyrophosphatase/phosphodiesterase 1 , dgf , ectonucleotide pyrophosphatase/phosphodiesterase family member 1 , ectonucleotidase enpp1 , E-NPP 1 , Ly-41 antigen , alkaline phosphodiesterase 1 , membrane component chromosome 6 surface marker 1 , membrane component, chromosome 6, surface marker 1 , phosphodiesterase I/nucleotide pyrophosphatase 1 , plasma-cell membrane glycoprotein 1 , plasma-cell membrane glycoprotein PC-1 , 1 ectonucleotide pyrophosphatase/phosphodiesterase 1 , lymphocyte antigen 41 , phosphodiesterase I/nucleotide pyrophosphatase 1; 1 ectonucleotide pyrophosphatase/phosphodiesterase 1 , tiptoe walking

100073097 Equus caballus
426929 Gallus gallus
463002 Pan troglodytes
562399 Danio rerio
615535 Bos taurus
100137399 Papio anubis
100422807 Xenopus (Silurana) tropicalis
100462923 Xenopus laevis
100562666 Anolis carolinensis
5167 Homo sapiens
18605 Mus musculus
85496 Rattus norvegicus
100009517 Oryctolagus cuniculus
476153 Canis lupus familiaris
100037271 Sus scrofa
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