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ENPP1 Products

(Ectonucleotide Pyrophosphatase/phosphodiesterase 1 (ENPP1))

Categories

This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq, Jul 2008].

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Featured ENPP1 Categories

ENPP1 Antibodies

High quality antibodies with extensive validation data.

ENPP1 ELISA Kits

Reliable ELISA kits for a wide range of species.

ENPP1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ENPP1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
  • (7)
Cat. No. ABIN185487
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
  • (3)
Cat. No. ABIN2854438
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, ICC
Validations
  • (1)
  • (4)
Cat. No. ABIN1858719
Quantity 100 μL
Datasheet Datasheet

Recommended ENPP1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6955501
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966450
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6973804
Quantity 96 tests
Datasheet Datasheet

Recommended ENPP1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7274535
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352823
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1782407
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our ENPP1 products

Liu, Wang, Hou, He, Ma, Ye, Yu, Chen, Wang, Zhang: "Chondrocyte-derived exosomes promote cartilage calcification in temporomandibular joint osteoarthritis." in: Arthritis research & therapy, Vol. 24, Issue 1, pp. 44, (2022) (PubMed).

Trapero, Jover, Fernández-Montolí, García-Tejedor, Vidal, Gómez de Aranda, Ponce, Matias-Guiu, Martín-Satué: "Analysis of the ectoenzymes ADA, ALP, ENPP1, and ENPP3, in the contents of ovarian endometriomas as candidate biomarkers of endometriosis." in: American journal of reproductive immunology (New York, N.Y. : 1989), Vol. 79, Issue 2, (2018) (PubMed).

Takeda, Miyazaki, Kobayashi, Nishino, Goto, Matsunaga, Ooi, Shirakawa, Tani, Kawamura, Komai, Kambe: "Zinc deficiency causes delayed ATP clearance and adenosine generation in rats and cell culture models." in: Communications biology, Vol. 1, pp. 113, (2018) (PubMed).

Huang, Chang, Kuo, Chen, Jeng, Chang, Shew, Hu, Lee: "Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate." in: Nature communications, Vol. 8, pp. 14706, (2018) (PubMed).

Lee, Fiene, Li, Hanck, Brylev, Fedorov, Lecka, Haider, Pietzsch, Zimmermann, Sévigny, Kortz, Stephan, Müller: "Polyoxometalates--potent and selective ecto-nucleotidase inhibitors." in: Biochemical pharmacology, Vol. 93, Issue 2, pp. 171-81, (2015) (PubMed).

de la Croix Ndong, Makowski, Uppuganti, Vignaux, Ono, Perrien, Joubert, Baglio, Granchi, Stevenson, Rios, Nyman, Elefteriou: "Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1." in: Nature medicine, Vol. 20, Issue 8, pp. 904-10, (2014) (PubMed).

Lau, Doucet, Stadel, Huang, Weber, Kominsky: "Enpp1: a potential facilitator of breast cancer bone metastasis." in: PLoS ONE, Vol. 8, Issue 7, pp. e66752, (2013) (PubMed).

Bertrand, Nitschke, Fuerst, Hermann, Schäfers, Sherwood, Nalesso, Ruether, Rutsch, DellAccio, Pap: "Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice." in: Annals of the rheumatic diseases, Vol. 71, Issue 7, pp. 1249-53, (2012) (PubMed).

Foster, Nagatomo, Nociti, Fong, Dunn, Tran, Wang, Narisawa, Millán, Somerman: "Central role of pyrophosphate in acellular cementum formation." in: PLoS ONE, Vol. 7, Issue 6, pp. e38393, (2012) (PubMed).

Pan, Ciociola, Saraf, Tumurbaatar, Tuvdendorj, Prasad, Chandalia, Abate: "Metabolic consequences of ENPP1 overexpression in adipose tissue." in: American journal of physiology. Endocrinology and metabolism, Vol. 301, Issue 5, pp. E901-11, (2011) (PubMed).

Synonyms and alternative names related to ENPP1

ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), ectonucleotide pyrophosphatase/phosphodiesterase 1 (enpp1), ectonucleotide pyrophosphatase/phosphodiesterase 1 L homeolog (enpp1.L), ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1), 4833416E15Rik, AI428932, ARHR2, C76301, CD203c, E-NPP1, ENPP1, Ly-41, M6S1, NPP1, NPPS, Npps, PC-1, Pc1, Pca, Pca-1, PCA1, PDNP1, Pdnp1, si:ch211-142e24.2, ttw, twy, zgc:136238

Protein level used designations for ENPP1

  • ectonucleotide pyrophosphatase/phosphodiesterase 1
  • dgf
  • ectonucleotide pyrophosphatase/phosphodiesterase family member 1
  • ectonucleotidase enpp1
  • E-NPP 1
  • Ly-41 antigen
  • alkaline phosphodiesterase 1
  • membrane component chromosome 6 surface marker 1
  • membrane component, chromosome 6, surface marker 1
  • phosphodiesterase I/nucleotide pyrophosphatase 1
  • plasma-cell membrane glycoprotein 1
  • plasma-cell membrane glycoprotein PC-1
  • 1 ectonucleotide pyrophosphatase/phosphodiesterase 1
  • lymphocyte antigen 41
  • phosphodiesterase I/nucleotide pyrophosphatase 1; 1 ectonucleotide pyrophosphatase/phosphodiesterase 1
  • tiptoe walking
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