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Browse our Fukutin Proteins (FKTN)

Full name:
Fukutin Proteins (FKTN)
On www.antibodies-online.com are 7 Fukutin (FKTN) Proteins from 4 different suppliers available. Additionally we are shipping Fukutin Antibodies (64) and Fukutin Kits (2) and many more products for this protein. A total of 78 Fukutin products are currently listed.
Synonyms:
CMD1X, D830030O17Rik, Fcmd, FKTN, im:7163166, LGMD2M, MDDGA4, MDDGB4, MDDGC4, zgc:162828
list all proteins Gene Name GeneID UniProt
FKTN 2218 O75072
FKTN 246179 Q8R507
Rat FKTN FKTN 362520  

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Fukutin Proteins (FKTN) by Origin

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More Proteins for Fukutin Interaction Partners

Zebrafish Fukutin (FKTN) interaction partners

  1. Fukutin and FKRP have functions that affect ocular development in zebrafish independently of dystroglycan.

  2. Muscle pathology in embryos lacking Fukutin or FKRP (show FKRP Proteins) is different from loss of dystroglycan; knockdown of Fukutin or FKRP (show FKRP Proteins) leads to a notochord defect and a perturbation of laminin expression before muscle degeneration.

Human Fukutin (FKTN) interaction partners

  1. Fukutin and fukutin-related protein (show FKRP Proteins) are sequentially acting Rbo5P transferases that use cytidine diphosphate ribitol.

  2. Fukutin role in in tumor progression in gastric cancer

  3. Mutation in the fukutin gene is associated with Fukuyama congenital muscular dystrophy and microcephaly.

  4. four new non-Japanese patients with FKTN mutations and congenital muscular dystrophy

  5. FKTN mutations are the most common genetic cause of congenital muscular dystrophies with defective alpha-dystroglycan glycosylation in Korea

  6. In Fukuyama congenital muscular dystrophy (FCMD) cases, expression of fukutin looked decreased.

  7. Fukutin is associated with Walker-Warburg syndrome.

  8. Data suggest that fukutin and fukutin-related protein (FKRP (show FKRP Proteins)) may be involved at different steps in O-mannosylglycan synthesis of alpha-dystroglycan, and FKRP (show FKRP Proteins) is most likely involved in the initial step in this synthesis.

  9. Fukutin seems to bind to both the hypoglycosylated and fully glycosylated form of alpha-dystroglycan, and seems bind to the core area rather than the sugar chain of alpha-dystroglycan

  10. Walker-Warburg syndrome carries a homozygous-single nucleotide insertion that produces a frameshift, or 2 mutations, a point mutation that produces an amino acid substitution, & deletion in 3'UTR that affects the polyadenylation signal of fukutin gene.

Mouse (Murine) Fukutin (FKTN) interaction partners

  1. Rapamycin treatment in fukutin-deficient mouse model of dystroglycanopathy delays/reduces disease burden.

  2. Fktn deficient mice express moderate to severe muscular dystrophy; glycosylated alpha-dystroglycan has a unique role in muscle regeneration in these mice

  3. Mouse fukutin deletion impairs dystroglycan processing, recapitulates muscular dystrophy and is relevant to modifications near the dystroglycan O-mannose sugar.

  4. disease-causing missense mutations cause abnormal folding and localization of fukutin protein

  5. the highly hydrophobic transmembrane domain of Fukutin-1 was purified; the identity of the peptide and revealed that in hydrophobic solvents mimicking the bilayer, the peptide adopts a well-structured alpha-helix as predicted from the sequence.

  6. Fukuyama-type congenital muscular dystrophy (FCMD) murine ortholog, Fcmd is 90% identical to that of its human counterpart

  7. Merosin (show LAMA2 Proteins)-deficient congenital muscular dystrophy with mental retardation and cerebellar cysts, unlinked to the FCMD locus, in three Tunisian patients

  8. These results support the hypothesis that fukutin is involved in the glycosylation process of alpha-DG and that a defect in this process plays an essential role in the pathogenesis of FCMD.

  9. The basal lamina of the cortical surface in chimeras showed defects at E14, coinciding with the earliest time point at which ectopia were detected

  10. From these findings, we propose that fukutin forms a complex with POMGnT1 (show POMGNT1 Proteins) and may modulate its enzymatic activity.

Fukutin (FKTN) Protein Profile

Protein Summary

The protein encoded by this gene is a putative transmembrane protein that is localized to the cis-Golgi compartment, where it may be involved in the glycosylation of alpha-dystroglycan in skeletal muscle. The encoded protein is thought to be a glycosyltransferase and could play a role in brain development. Defects in this gene are a cause of Fukuyama-type congenital muscular dystrophy (FCMD), Walker-Warburg syndrome (WWS), limb-girdle muscular dystrophy type 2M (LGMD2M), and dilated cardiomyopathy type 1X (CMD1X). Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with Fukutin (FKTN)

  • Fukuyama type congenital muscular dystrophy (fukutin) (FCMD)
  • fukutin (FKTN)
  • fukutin (fktn)
  • Fukutin (Bm1_09375)
  • Fukutin (Bm1_09380)
  • Fukutin (Bm1_44655)
  • fukutin (Fktn)
  • fukutin-like (LOC536891)
  • CMD1X protein
  • D830030O17Rik protein
  • Fcmd protein
  • FKTN protein
  • im:7163166 protein
  • LGMD2M protein
  • MDDGA4 protein
  • MDDGB4 protein
  • MDDGC4 protein
  • zgc:162828 protein

Protein level used designations for Fukutin Proteins (FKTN)

Fukuyama type congenital muscular dystrophy (fukutin) , fukutin , Fukutin , Fukuyama type congenital muscular dystrophy protein , patient fukutin , Fukuyama type congenital muscular dystrophy homolog

GENE ID SPECIES
712201 Macaca mulatta
427303 Gallus gallus
100006345 Danio rerio
464634 Pan troglodytes
100054199 Equus caballus
495324 Xenopus laevis
6096801 Brugia malayi
6096802 Brugia malayi
6103815 Brugia malayi
100124956 Xenopus (Silurana) tropicalis
2218 Homo sapiens
481652 Canis lupus familiaris
246179 Mus musculus
362520 Rattus norvegicus
100521942 Sus scrofa
536891 Bos taurus
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