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Insulin (show INS Proteins) resistance in obese boys leads to up-regulation of INSIG2 (show INSIG2 Proteins) gene expression as well as to down-regulation of PFKFB1, PFKFB3 (show PFKFB3 Proteins), and HK2 (show HK2 Proteins) genes in the blood cells as compared to obese patients with normal insulin (show INS Proteins) sensitivity.
Results describe structural differences between two isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from liver and testis.
Data show that cardiac overexpression of kinase-deficient PFK-2 reduces cardiac glycolysis that produced negative consequences to the heart including hypertrophy, fibrosis, and reduced cardiomyocyte function.
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.
, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1-like
, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
, 6PF-2-K/Fru-2,6-P2ASE liver isozyme
, 6PF-2-K/Fru-2,6-P2ase 1
, PFK/FBPase 1
, 6PF-2-K/Fru-2,6-P2ase liver isozyme
, PFK-2/FBPase-2 gene A
, 6-phosphofructo-2 kinase /fructose-2,6-biphosphatase 1