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Browse our 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 Proteins (PFKFB1)

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6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 Proteins (PFKFB1)
On are 11 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1) Proteins from 6 different suppliers available. Additionally we are shipping 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 Antibodies (67) and 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 Kits (4) and many more products for this protein. A total of 88 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 products are currently listed.
F6PK, HL2K, Pfkfb01, PFKFB1, PFRX, wu:fi11h10, zgc:55328
list all proteins Gene Name GeneID UniProt
PFKFB1 5207 P16118
PFKFB1 18639 P70266
PFKFB1 24638 P07953

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6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 Proteins (PFKFB1) by Origin

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More Proteins for 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 Interaction Partners

Human 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1) interaction partners

  1. Insulin (show INS Proteins) resistance in obese boys leads to up-regulation of INSIG2 (show INSIG2 Proteins) gene expression as well as to down-regulation of PFKFB1, PFKFB3 (show PFKFB3 Proteins), and HK2 (show HK2 Proteins) genes in the blood cells as compared to obese patients with normal insulin (show INS Proteins) sensitivity.

  2. Results describe structural differences between two isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from liver and testis.

Mouse (Murine) 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1) interaction partners

  1. Data show that cardiac overexpression of kinase-deficient PFK-2 reduces cardiac glycolysis that produced negative consequences to the heart including hypertrophy, fibrosis, and reduced cardiomyocyte function.

6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1) Protein Profile

Protein Summary

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1)

  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (pfkfb1)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (PFKFB1)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (Pfkfb1)
  • F6PK protein
  • HL2K protein
  • Pfkfb01 protein
  • PFKFB1 protein
  • PFRX protein
  • wu:fi11h10 protein
  • zgc:55328 protein

Protein level used designations for PFKFB1

6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase , 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 , 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1-like , 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 , 6PF-2-K/Fru-2,6-P2ASE liver isozyme , 6PF-2-K/Fru-2,6-P2ase 1 , PFK/FBPase 1 , fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase , 6PF-2-K/Fru-2,6-P2ase liver isozyme , PFK-2/FBPase-2 gene A , 6-phosphofructo-2 kinase /fructose-2,6-biphosphatase 1

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100014887 Monodelphis domestica
100078789 Ornithorhynchus anatinus
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100606264 Nomascus leucogenys
5207 Homo sapiens
18639 Mus musculus
24638 Rattus norvegicus
282304 Bos taurus
491903 Canis lupus familiaris
100233197 Sus scrofa
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