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Human APOE ELISA Kit for Sandwich ELISA - ABIN2683480
Schultz, Lyons, Franz, Grant, Boake, Jacobson, Xian, Schellenberg, Eisen, Kremen: Apolipoprotein E genotype and memory in the sixth decade of life. in Neurology 2008
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Human APOE ELISA Kit for Sandwich ELISA - ABIN417091
Wu, Liu, Lei, Zhang: Comment on: Cerebrospinal fluid apolipoprotein E concentration decreases after seizure. in Seizure : the journal of the British Epilepsy Association 2010
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Human APOE ELISA Kit for Sandwich ELISA - ABIN2345037
Lee, Acosta, Stoeck, Long, Hiet, Mueller, Fackler, Kallis, Bartenschlager: Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins. in Journal of virology 2014
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Mouse (Murine) APOE ELISA Kit for Sandwich ELISA - ABIN415472
Escolà-Gil, Chen, Julve, Quesada, Santos, Metso, Tous, Jauhiainen, Blanco-Vaca: Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties. in Biochimica et biophysica acta 2013
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Human APOE ELISA Kit for Sandwich ELISA - ABIN612665
Butt, Bernhardt, Smolenski, Kotsonis, Fröhlich, Sickmann, Meyer, Lohmann, Schmidt: Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases. in The Journal of biological chemistry 2000
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Rat (Rattus) APOE ELISA Kit for Sandwich ELISA - ABIN579777
Burgos-Ramos, Sackmann-Sala, Baquedano, Cruz-Topete, Barrios, Argente, Kopchick: Central leptin and insulin administration modulates serum cytokine- and lipoprotein-related markers. in Metabolism: clinical and experimental 2012
Human APOE ELISA Kit for Sandwich ELISA - ABIN2532293
Johnson, Drugan, Miller, Evans: 38 in 1991
choroid plexus/CSF (show CSF2 ELISA Kits) provides an additional source of apoE and the glymphatic fluid transporting system delivers it to brain via the periarterial space
Longxuetongluo capsule inhibits atherosclerosis progression in high-fat diet-induced ApoE(-/-) mice by improving endothelial dysfunction via MAPK (show MAPK1 ELISA Kits)/IKK (show CHUK ELISA Kits)/IkappaB/NF-kappaB (show NFKB1 ELISA Kits) signaling pathway.
Major orthopedic surgery in ApoE-/- mice triggers a systemic inflammatory response. Atherosclerotic plaque area is enlarged after surgery mainly due to an increase of the necrotic core.
Saffron (Crocus sativus) protects against myocardial ischemia-reperfusion injury in Wild Type and ApoE((-/-)) mice via Nrf2 (show NFE2L2 ELISA Kits) pathway.
Zinc supplementation has a therapeutic effect on the advanced atherosclerosis of ApoE gene-deleted mice, which can significantly improve the efficacy of irbesartan.
Decreased Hexim-1 (show HEXIM1 ELISA Kits) expression does not alter cholesterol metabolism in ApoE null background after high fat diet. However, it promotes stable atherosclerotic plaque and decreased steatosis by promoting the anti-inflammatory TGFbeta (show TGFB1 ELISA Kits) pathway and blocking the expression of the inducible and pro-inflammatory expression of SOCS3 (show SOCS3 ELISA Kits) respectively.
DPP-4 (show DPP4 ELISA Kits) inhibitor teneligliptin inhibited atherogenesis in ApoE knockout mice, at least partially, through attenuation of the inflammatory phenotype of perivascular adipose tissue.
Loss of ApoE potentiates a semi-chronic inflammatory arthritis.
apoE4 interacts wiith insulin receptor (show INSR ELISA Kits) and impairs its trafficking by trapping it in the endosomes, leading to impaired insulin (show INS ELISA Kits) signaling and insulin (show INS ELISA Kits)-stimulated mitochondrial respiration and glycolysis.
UCP-2 (show UCP2 ELISA Kits) prevents angiotensin-II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice via antioxidant and antiapoptotic activities.
indicates that measurable apolipoprotein E-related brain atrophy does not occur in early adulthood and midlife
Self-reported sleep duration, napping, and trouble falling/staying asleep differ by APOE genotype; studies are needed to examine whether APOE promotes AD by degrading sleep and to clarify the role of race in these associations
Study provides support for the argument that Apolipoprotein E (APOE varepsilon4+) and catechol-O-methyl transferase Met/Met genotypes can be used as predictors of faster cognitive decline in Parkinson's disease.
both apolipoprotein E and Abeta1-42 abundance can differ depending upon the type of CJD (show PRNP ELISA Kits).
report association of APOE and TOMM40 (show TOMM40 ELISA Kits) with behavioural variant frontotemporal dementia, and ARHGAP35 (show GRLF1 ELISA Kits) and SERPINA1 (show SERPINA1 ELISA Kits) with progressive non-fluent aphasia.
We conclude that ApoA-I (show APOA1 ELISA Kits) physically interacts with LL-37 and antagonizes LL-37-induced down-regulation of endothelial cell viability suggesting that this mechanism counteracts endothelial cell dysfunction.
Compared with APOE E3 carriers, E2 and E4 carriers performed worse in the cognitive domains of memory and global cognition. Identification of genetic contributors remains critical to understanding new pathways to prevent and treat dementia in the setting of T2 diabetes.
These results show that epsilon2 allele may favorably influence LDL-C, HD, and survival through three mechanisms. Two of them (HD- and survival-related (show CASZ1 ELISA Kits)) are pronounced in the long-living parents and their offspring; the survival-related (show CASZ1 ELISA Kits) mechanism is also sensitive to gender.
In elderly African Americans in an exercise program, non-APOEepsilon4 carriers showed a significant increase in brain-derived neurotrophic factor (show BDNF ELISA Kits) levels at the 6month time point while epsilon4 carriers did not.
Study used 3 and 7 month old EFAD mice, which express human APOE and over-express specifically human Abeta42 via 5 familial-Alzheimer's disease mutations, to investigate APOE genotype-specific effects on site-specific tau phosphorylation. Results suggest that the APOE4 genotype contributes to increased site-specific tau phosphorylation via activation of the calpain-CDK5 (show CDK5 ELISA Kits) signaling pathway.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (show APOA1 ELISA Kits) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 ELISA Kits) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB ELISA Kits), ApoE, MTP (show MTTP ELISA Kits), and LDLR (show LDLR ELISA Kits), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (show HSD11B1 ELISA Kits) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (show APOB ELISA Kits)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (show MTTP ELISA Kits)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3