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Human APOE ELISA Kit for Sandwich ELISA - ABIN2683480
Schultz, Lyons, Franz, Grant, Boake, Jacobson, Xian, Schellenberg, Eisen, Kremen: Apolipoprotein E genotype and memory in the sixth decade of life. in Neurology 2008
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Human APOE ELISA Kit for Sandwich ELISA - ABIN417091
Wu, Liu, Lei, Zhang: Comment on: Cerebrospinal fluid apolipoprotein E concentration decreases after seizure. in Seizure : the journal of the British Epilepsy Association 2010
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Human APOE ELISA Kit for Sandwich ELISA - ABIN2345037
Lee, Acosta, Stoeck, Long, Hiet, Mueller, Fackler, Kallis, Bartenschlager: Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins. in Journal of virology 2014
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Mouse (Murine) APOE ELISA Kit for Sandwich ELISA - ABIN415472
Escolà-Gil, Chen, Julve, Quesada, Santos, Metso, Tous, Jauhiainen, Blanco-Vaca: Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties. in Biochimica et biophysica acta 2013
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Rat (Rattus) APOE ELISA Kit for Sandwich ELISA - ABIN579777
Burgos-Ramos, Sackmann-Sala, Baquedano, Cruz-Topete, Barrios, Argente, Kopchick: Central leptin and insulin administration modulates serum cytokine- and lipoprotein-related markers. in Metabolism: clinical and experimental 2012
Human APOE ELISA Kit for Sandwich ELISA - ABIN612665
Butt, Bernhardt, Smolenski, Kotsonis, Fröhlich, Sickmann, Meyer, Lohmann, Schmidt: Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases. in The Journal of biological chemistry 2000
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Human APOE ELISA Kit for Sandwich ELISA - ABIN2532293
Johnson, Drugan, Miller, Evans: 38 in 1991
224 male F2 mice were generated from the two Apoe (-/-) strains to perform quantitative trait locus (QTL) analysis of atherosclerosis. F2 mice were fed 5 weeks of Western diet and analyzed for atherosclerotic lesions in the aortic root
Low dose dietary nitrate improves endothelial dysfunction and plaque stability in the ApoE-deficient mouse fed a high fat diet.
Ovariectomy and ApoE deficiency showed interaction potentializing the insulin (show INS ELISA Kits) resistance, increasing triglycerides levels and altering angiotensin-converting enzyme (ACE (show ACE ELISA Kits))-2 (show ACE2 ELISA Kits) and Mas (show MAS1 ELISA Kits) receptor gene expressions.
AMPK activation reduces the formation of atheromata-inducing macrophages in ApoE(-/-)-deficient mice by inhibiting expression of Ccr2, thereby preventing the Ccr2-mediated migration of Ly6C(hi) monocytes from the bone marrow.
Deletion of apolipoprotein E in astrocytes ameliorates the spatial learning and memory deficits in Alzheimer's disease by inhibiting TGF-beta (show TGFB1 ELISA Kits)/Smad2 (show SMAD2 ELISA Kits)/STAT3 (show STAT3 ELISA Kits) signaling.
choroid plexus/CSF (show CSF2 ELISA Kits) provides an additional source of apoE and the glymphatic fluid transporting system delivers it to brain via the periarterial space
Longxuetongluo capsule inhibits atherosclerosis progression in high-fat diet-induced ApoE(-/-) mice by improving endothelial dysfunction via MAPK (show MAPK1 ELISA Kits)/IKK (show CHUK ELISA Kits)/IkappaB/NF-kappaB (show NFKB1 ELISA Kits) signaling pathway.
Major orthopedic surgery in ApoE-/- mice triggers a systemic inflammatory response. Atherosclerotic plaque area is enlarged after surgery mainly due to an increase of the necrotic core.
Saffron (Crocus sativus) protects against myocardial ischemia-reperfusion injury in Wild Type and ApoE((-/-)) mice via Nrf2 (show NFE2L2 ELISA Kits) pathway.
Zinc supplementation has a therapeutic effect on the advanced atherosclerosis of ApoE gene-deleted mice, which can significantly improve the efficacy of irbesartan.
The data indicate that the APOE rs405509 T homozygote modulates the effect of APOE epsilon4 on both cognitive performance and brain gray matter structure
ApoE2 and apoE4 increase the risk for heart disease; ApoE4 also increases the risk for neurodegenerative diseases. (Review)
in a population with low levels of cerebrovascular disease and a lower prevalence of SNAP than the general population, APOE and known genetic drivers of AD do not appear to contribute to the neurodegeneration observed in SNAP
Data conclude that the ER-stress mediated reduction in apoA-I (show APOA1 ELISA Kits) transcription could be partly mediated via the inhibition of PPARalpha (show PPARA ELISA Kits) mRNA expression and activity. In addition, BET inhibition increased apoA-I (show APOA1 ELISA Kits) transcription, even if PPARalpha (show PPARA ELISA Kits) production and activity were decreased. Both BET inhibition and PPARalpha (show PPARA ELISA Kits) activation ameliorate the apoA-I (show APOA1 ELISA Kits) lowering effect of ER-stress and are therefore interesting targets to elev...
Elevated cholesterol and APOE 4 genotype are independent risk factors for cognitive decline in ART-adherent HIV(+) men aged >50 years. Treatment of dyslipidemia may be an effective strategy to reduce cognitive decline in older HIV(+) individuals.
Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 x 10(-8)) were identified for the interaction of the (apolipoprotein E) APOE epsilon4 allele with NFIC (show NFIC ELISA Kits) SNP.
These findings suggest that both the APOE epsilon4 allele and education appear to be associated with cognitive function even in centenarians, but the interaction between the epsilon4 allele and education might depend on gender in this cohort.
The results suggested positive association of a specific ApoE genotype and onset of non-lesional temporal lobe epilepsy.
protective role of epsilon4 on each subtypes of age-related macular degeneration (AMD (show AMD1 ELISA Kits)), but no supportive evidence of the association of epsilon2 with AMD (show AMD1 ELISA Kits). [meta-analysis]
Results suggest that in healthy mid-age individuals, carrying the e4 variant of APOE is not associated with disadvantaged performance on dynamic scaling and perceptual load measures of visuospatial attention, despite the established detrimental effects of this gene in older adults. Association of e2 genotype with slower visual search performance complicates premised protective effects of this allele in cognitive ageing.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (show APOA1 ELISA Kits) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 ELISA Kits) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB ELISA Kits), ApoE, MTP (show MTTP ELISA Kits), and LDLR (show LDLR ELISA Kits), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (show HSD11B1 ELISA Kits) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (show APOB ELISA Kits)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (show MTTP ELISA Kits)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3