Browse our Osteopontin Proteins (SPP1)

Full name:
Secreted phosphoprotein 1 Proteins (SPP1)
On are 54 Secreted phosphoprotein 1 (SPP1) Proteins from 18 different suppliers available. Additionally we are shipping Osteopontin Antibodies (443) and Osteopontin Kits (124) and many more products for this protein. A total of 643 Osteopontin products are currently listed.
2AR, AI463453, Apl-1, BNSP, Bsp, BSPI, Eta, ETA-1, OP, Opn, Opnl, OSP, Ric, SPP, Spp-1, SPP1, SPPase1, Spph1, zgc:111821
list all proteins Gene Name GeneID UniProt
SPP1 6696 P10451
SPP1 20750 P10923
SPP1 25353 P08721

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Osteopontin Proteins (SPP1) by Origin

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Top referenced Osteopontin Proteins

  1. Human Osteopontin Protein expressed in HEK-293 - ABIN2666563 : Yokosaki, Tanaka, Higashikawa, Yamashita, Eboshida: Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin. in Matrix biology : journal of the International Society for Matrix Biology 2005 (PubMed)
    Show all 5 references for 2666563

  2. Human Osteopontin Protein expressed in Escherichia coli (E. coli) - ABIN1047487 : Kiefer, Bauer, Barr: The cDNA and derived amino acid sequence for human osteopontin. in Nucleic acids research 1989 (PubMed)
    Show all 3 references for 1047487

  3. Human Osteopontin Protein expressed in Escherichia coli (E. coli) - ABIN668040 : Koh, da Silva, Bansal, Bansal, Sun, Lee, Glogauer, Sodek, Zohar: Role of osteopontin in neutrophil function. in Immunology 2007 (PubMed)
    Show all 2 references for 668040

  4. Human Osteopontin Protein expressed in Human Cells - ABIN2002652 : Nagasaka, Matsue, Matsushima, Aoki, Nakamura, Kambe, Kon, Uede, Shimada: Osteopontin is produced by mast cells and affects IgE-mediated degranulation and migration of mast cells. in European journal of immunology 2008 (PubMed)

  5. Human Osteopontin Protein expressed in HEK-293 Cells - ABIN2181569 : Christensen, Nielsen, Haselmann, Petersen, Sørensen: Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications. in The Biochemical journal 2005 (PubMed)

More Proteins for Osteopontin Interaction Partners

Human Secreted phosphoprotein 1 (SPP1) interaction partners

  1. Upregulation of PD-L1 (show CD274 Proteins) by SPP1 mediates macrophage polarization and facilitates immune escape in lung adenocarcinoma.

  2. Expression and inactivation of osteopontin-degrading PHEX (show PHEX Proteins) enzyme in squamous cell carcinoma

  3. These results describe the pleiotropic roles of OPN in the tumor metastasis cascade, which indicate its potential as an effective target for both early and advanced tumors.

  4. Osteopontin exon 4 was associated with a favorable response to tamoxifen, but a poor response to chemotherapy with CMF (cyclophosphamide, methotrexate, fluorouracil) in 119 Polish breast cancer patients.

  5. Results show that the presence of OPN and TSP-1 (show THBS1 Proteins) in the serum of patients with non-small cell lung cancer may reflect the aggressiveness of the tumor.

  6. no evidence for an association between SNPs on the osteopontin gene and plasma OPN levels or the presence of sarcoidosis

  7. Higher levels of OPN in cervical cancer patients compared to healthy subjects.OPN fragments with an intact thrombin (show F2 Proteins)-sensitive site circulate in cervical cancer patients.

  8. Study characterized SPP1 in the human central nervous system by investigating its expression in the primary somatosensory cortex and spinal cord, in addition to primary motor cortex. Results suggest that SPP1 has a role in the specialization of motor projection neurons and suggest that its reduced expression may be implicated in the neurodegeneration seen in ALS.

  9. Study extended understanding of the effect of phosphorylation on the recombinant human-like osteopontin rOPN; showed that phosphorylation can thus selectively change the dynamic behavior of even a highly disordered protein such as osteopontin. Through such an effect on rOPN, phosphorylation can direct allosteric mechanisms, interactions with substrates, cofactors and, in this case, amorphous or crystalline biom

  10. OPN promotes chemo-resistance of hepatocellular carcinoma via autophagy pathway.

Pig (Porcine) Secreted phosphoprotein 1 (SPP1) interaction partners

  1. These data suggested that methylation in the OPN promoter plays a crucial role in the regulation of OPN expression that we found in cloned pigs genome.

  2. The striking breed differences between hyperprolific Large White and Meishanin pigs of secreted phospoprotein 1 expression in endometrium suggest that SPP1 may be associated with placental efficiency.

  3. Microglia incubated in vitro with different concentrations (0.1 fM-1 nM) of recombinant osteopontin showed increased proliferation at 10 fM.

  4. results of this study reveal faster growth rate and differences in pig productivity according to genotypes of the SPP1 gene

  5. Osteopontin could play an important role in the development of neointimal hyperplasia in venous conduits after coronary artery bypass grafting.

  6. A different MSSCP pattern was shown in osteopontin which indicates that mutation is located in promotor region; the A --> G transitions was identified in two positions -617 and -608

  7. The 3' terminal end of the first intron of porcine SPP1 harbors a C/EBPbeta (show CEBPB Proteins) binding site and this binding site is negatively affected by the mutant G allele.

  8. in pregnant pigs SPP1 is induced by conceptus estrogen in uterine luminal epithelium and is regulated in a manner coincident with placental progesterone production

  9. osteopontin promotes pathologic mineralization via calcium pyrophosphate dihydrate crystal formation in articular cartilage.

  10. Osteopontin is detected in the majority of germ cells and is involved in spermatogenesis in boar testis.

Mouse (Murine) Secreted phosphoprotein 1 (SPP1) interaction partners

  1. Findings demonstrate that claudin-low mammary tumor cells rely on OPN for proliferation, survival and migration as knockdown of OPN using siRNA inhibited proliferation and migration while increasing apoptosis.

  2. TSC1 (show TSC1 Proteins)/TSC2 complex upregulation of OPN expression is mediated by transcription factor SOX9 (show SOX9 Proteins) in an mTOR (show FRAP1 Proteins)-independent manner. Moreover, ablation of OPN by deficient TSC1 (show TSC1 Proteins)/TSC2 complex contributed to inactivation of AKT (show AKT1 Proteins) in TSC (show SLC12A3 Proteins) cells

  3. Intracellular OPN (iOPN) diminished the population size of myeloid progenitor cells and myeloid cells, and secreted OPN (sOPN) increase the population size of lymphoid cells. The total effect of OPN on skewing the leukocyte population balance was observed as host sensitivity to early systemic infection with Candida albicans and T cell-mediated colitis.

  4. this study shows that OPN promotes sepsis in Pseudomonas aeruginosa-infected mice and potentially blocks B cell-dependent immunity

  5. observed a marked decrease of renal gene expression and urinary excretion of osteopontin in Npt2a (show SLC34A1 Proteins)(-/-) mice

  6. data suggest the possibility that Opn might regulate the homeostasis of intestinal microflora through maintenance of TCRgammadelta+ IELs, possibly by support of IEL survival

  7. OPN secreted by follicular CD153 (show TNFSF8 Proteins)(+) senescence-associated T cells in germinal centers (GCs (show UGCG Proteins)) promotes a continuous supply of intracellular autoantigens via apoptotic cells, thus playing a key role in the progression of the autoreactive GC reaction and leading to pathogenic autoantibody production in lupus-prone mice.

  8. study demonstrated an anti-tumorigenic role of OPN in transgenic adenocarcinoma of the mouse prostate (TRAMP (show DPT Proteins)) development and also suggests that the contribution of OPN to tumor development depends on the type of tumor as well as the source and isoform of OPN

  9. These data suggest a critical role for reduced stroma-derived osteopontin for hematopoietic stem cell aging.

  10. Osteopontin is a key mediator released by senescent pulmonary artery smooth muscle cells and contributes to pulmonary hypertension progression.

Cow (Bovine) Secreted phosphoprotein 1 (SPP1) interaction partners

  1. This implies that a majority of the acidic residues within OPN must be engaged in calcium interaction under physiological conditions.

  2. Genetic variations in the SPP1 promoter affect gene expression and the level of osteopontin secretion into bovine milk.

  3. Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.

  4. osteopontin (OPN) can serve as a process-directing agent for the intrafibrillar mineralization of collagen.

  5. Results suggest a mechanism of the interaction of UO2(2+) with bone metabolism and a new role for osteopontin (OPN) as a metal transporter.

  6. Upon induction of luteolysis, SPP1 serves as a signaling molecule to recruit or activate immune cells to facilitate luteal regression and tissue degradation.

  7. OPN strongly reduces the amount of biofilm formed in a well-defined laboratory model of acidogenic dental biofilm.

  8. This study demonstrates that adhesion of isolated neonatal rat osteoclasts in vitro was augmented on bovine milk osteopontin (bmOPN) with post-translational modifications (PTMs) compared to human Escherichia-coli-derived recombinant OPN without PTMs.

  9. topographical distribution of both the in vivo and in vitro phosphorylation sites of bone sialoprotein (show CRISP1 Proteins)

  10. the bovine osteopontin gene has two functionally distinct clusters of haplotypes within the QTL region on chromosome 6

Rabbit Secreted phosphoprotein 1 (SPP1) interaction partners

  1. Infection of urinary tract by Escherichia coli caused higher than normal expression of promoter protein osteopontin and mucosal damage at renal tubular cells.

Osteopontin (SPP1) Protein Profile

Protein Summary

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000

Alternative names and synonyms associated with Osteopontin (SPP1)

  • secreted phosphoprotein 1 (spp1)
  • secreted phosphoprotein 1 (SPP1)
  • secreted phosphoprotein 1 (Spp1)
  • sphingosine-1-phosphate phosphatase 1 (Sgpp1)
  • sphingosine-1-phosphate phosphatase 1 (SGPP1)
  • 2AR protein
  • AI463453 protein
  • Apl-1 protein
  • BNSP protein
  • Bsp protein
  • BSPI protein
  • Eta protein
  • ETA-1 protein
  • OP protein
  • Opn protein
  • Opnl protein
  • OSP protein
  • Ric protein
  • SPP protein
  • Spp-1 protein
  • SPP1 protein
  • SPPase1 protein
  • Spph1 protein
  • zgc:111821 protein

Protein level used designations for SPP1

spp1 protein , osteopontin , SPP1/CALPHA1 fusion , early T-lymphocyte activation 1 , nephropontin , osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein , secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) , urinary stone protein , uropontin , SPP-1 , bone sialoprotein 1 , 44 kDa bone phosphoprotein , calcium oxalate crystal growth inhibitor protein , early T-lymphocyte activation 1 protein , minopontin , osteopontin-like protein , Sialoprotein (osteopontin) , bone sialoprotein I , osteopontin-K , OC-1 , secreted phosphoprotein-1 , SPPase1 , sphingosine-1-phosphatase 1 , hSPP1 , hSPPase1 , spp1

432385 Danio rerio
6696 Homo sapiens
478471 Canis lupus familiaris
397087 Sus scrofa
20750 Mus musculus
25353 Rattus norvegicus
281499 Bos taurus
100008982 Oryctolagus cuniculus
395210 Gallus gallus
443058 Ovis aries
100860805 Capra hircus
81535 Mus musculus
81537 Homo sapiens
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