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In Osteoarthritis tissues, OPN mRNA, and NEAT1 expression was upregulated, whereas miR (show MLXIP Proteins)-181c expression was downregulated, indicating that targeting NEAT1 to rescue miR (show MLXIP Proteins)-181c expression so as to inhibit OPN expression and synoviocyte proliferation
IL-6 (show IL6 Proteins) and sIL (show PMEL Proteins)-6R induced by IL-1beta (show IL1B Proteins) may trigger IL-6 (show IL6 Proteins) trans-signaling, contributing to the upregulation of OPN in THP-1 macrophages. Macrophages may be used as a source of IL-6 (show IL6 Proteins) and sIL (show PMEL Proteins)-6R and evoke IL-6 (show IL6 Proteins) trans-signaling.
OPN is a key mediator of intracerebral tumor growth, invasion, and dissemination in central nervous system lymphoma, and these effects depend upon activation of NF-kappaB (show NFKB1 Proteins).
These observations provided evidence on the protective role of OPN in pancreatic islets under diabetic condition, and may point to novel therapeutic targets for islet protection in T2D.
Osteopontin, neopterin, and myeloperoxidase (show MPO Proteins) were independently associated with the risk of recurrent stroke and improved risk classification when added to a clinical risk algorithm
The findings of an excess of inhibitory OPN near osteocytes and their cell processes, and in dentin, spatially correlates with the defective mineralization observed at these sites in the skeleton and teeth of X-linked hypophosphatemia patients.
Simvastatin reversed IL-13 (show IL13 Proteins)-suppressed adenosine deaminase (show ADA Proteins) activity, leading to the down-regulation of adenosine signaling and inhibition osteopontin expression through the direct inhibition of IL-13 (show IL13 Proteins)-activated STAT6 (show STAT6 Proteins) pathway in COPD (show ARCN1 Proteins).
Epistatic effects of SPP rs4754 with SPARC (show SPARC Proteins) polymorphisms are associated with gastric carcinogenesis.
this study indicates that OPN can induce epithelial-mesenchymal transition of hepatocellular carcinoma cells through increasing vimentin (show VIM Proteins) stability
This review summarizes the current understanding of OPN in liver diseases. Further understanding of the pathophysiological role of OPN in cellular interactions and molecular mechanisms associated with hepatic inflammation, fibrosis and cancer may contribute to the development of novel strategies for clinical diagnosis, monitoring and therapy of liver diseases.
Data show that, together, osteocalcin (OC (show BGLAP Proteins)) and osteopontin (OPN) play important roles in determining bone size, shape, and strength.
Results show that BSP (show KLK6 Proteins) and OPN are present in the mineralized tissues of fibrocartilaginous enthuses.
AMPK (show PRKAA1 Proteins) was sufficient to stimulate osteogenesis of MC3T3-E1 cells and inhibit adipogenesis of 3T3-L1 cells through the AMPK (show PRKAA1 Proteins)-Gfi1 (show ZNF163 Proteins)-OPN axis.
Excess osteopontin exacerbated sarcolemmal injury, and correspondingly, that loss of osteopontin reduced injury extent both in isolated myofibers and in muscle.
A MMP-9-cleaved OPN fragment, OPN-32kDa, was responsible for inducing expansion of myeloid-derived suppressor cells, which may contribute to 3LL tumor's evasion of the immune response.
OPN played a critical role in activating the migration of Mesenchymal stem cells to injured sites and their differentiation into specific skin cell types during skin wound healing.
Findings demonstrate that claudin-low mammary tumor cells rely on OPN for proliferation, survival and migration as knockdown of OPN using siRNA inhibited proliferation and migration while increasing apoptosis.
TSC1 (show TSC1 Proteins)/TSC2 complex upregulation of OPN expression is mediated by transcription factor SOX9 (show SOX9 Proteins) in an mTOR (show FRAP1 Proteins)-independent manner. Moreover, ablation of OPN by deficient TSC1 (show TSC1 Proteins)/TSC2 complex contributed to inactivation of AKT (show AKT1 Proteins) in TSC (show SLC12A3 Proteins) cells
Intracellular OPN (iOPN) diminished the population size of myeloid progenitor cells and myeloid cells, and secreted OPN (sOPN) increase the population size of lymphoid cells. The total effect of OPN on skewing the leukocyte population balance was observed as host sensitivity to early systemic infection with Candida albicans and T cell-mediated colitis.
this study shows that OPN promotes sepsis in Pseudomonas aeruginosa-infected mice and potentially blocks B cell-dependent immunity
This implies that a majority of the acidic residues within OPN must be engaged in calcium interaction under physiological conditions.
Genetic variations in the SPP1 promoter affect gene expression and the level of osteopontin secretion into bovine milk.
Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.
osteopontin (OPN) can serve as a process-directing agent for the intrafibrillar mineralization of collagen.
Results suggest a mechanism of the interaction of UO2(2+) with bone metabolism and a new role for osteopontin (OPN) as a metal transporter.
Upon induction of luteolysis, SPP1 serves as a signaling molecule to recruit or activate immune cells to facilitate luteal regression and tissue degradation.
OPN strongly reduces the amount of biofilm formed in a well-defined laboratory model of acidogenic dental biofilm.
This study demonstrates that adhesion of isolated neonatal rat osteoclasts in vitro was augmented on bovine milk osteopontin (bmOPN) with post-translational modifications (PTMs) compared to human Escherichia-coli-derived recombinant OPN without PTMs.
topographical distribution of both the in vivo and in vitro phosphorylation sites of bone sialoprotein (show CRISP1 Proteins)
the bovine osteopontin gene has two functionally distinct clusters of haplotypes within the QTL region on chromosome 6
These data suggested that methylation in the OPN promoter plays a crucial role in the regulation of OPN expression that we found in cloned pigs genome.
The striking breed differences between hyperprolific Large White and Meishanin pigs of secreted phospoprotein 1 expression in endometrium suggest that SPP1 may be associated with placental efficiency.
Microglia incubated in vitro with different concentrations (0.1 fM-1 nM) of recombinant osteopontin showed increased proliferation at 10 fM.
results of this study reveal faster growth rate and differences in pig productivity according to genotypes of the SPP1 gene
Osteopontin could play an important role in the development of neointimal hyperplasia in venous conduits after coronary artery bypass grafting.
A different MSSCP pattern was shown in osteopontin which indicates that mutation is located in promotor region; the A --> G transitions was identified in two positions -617 and -608
The 3' terminal end of the first intron of porcine SPP1 harbors a C/EBPbeta (show CEBPB Proteins) binding site and this binding site is negatively affected by the mutant G allele.
in pregnant pigs SPP1 is induced by conceptus estrogen in uterine luminal epithelium and is regulated in a manner coincident with placental progesterone production
osteopontin promotes pathologic mineralization via calcium pyrophosphate dihydrate crystal formation in articular cartilage.
Osteopontin is detected in the majority of germ cells and is involved in spermatogenesis in boar testis.
Infection of urinary tract by Escherichia coli caused higher than normal expression of promoter protein osteopontin and mucosal damage at renal tubular cells.
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.
, early T-lymphocyte activation 1
, osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
, urinary stone protein
, 44 kDa bone phosphoprotein
, bone sialoprotein 1
, calcium oxalate crystal growth inhibitor protein
, early T-lymphocyte activation 1 protein
, osteopontin-like protein
, Sialoprotein (osteopontin)
, bone sialoprotein I
, spp1 protein
, secreted phosphoprotein-1
, LOW QUALITY PROTEIN: osteopontin