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These results suggested that the role of SLIT1 is altered postnatally and that this is particularly important for prefrontal connectivity in the Old World monkey cortex.
Slit acts via Robo2 (show ROBO2 Proteins) in dendrites as a branching/growth factor but not in guidance, while Robo2 (show ROBO2 Proteins) and Robo3 (show ROBO3 Proteins) function in concert in axons to mediate axonal interactions and respond to Slits as guidance factors
Data indicate the roles of Slit1/Robo1 (show ROBO1 Proteins) and Netrin1/DCC (show DCC Proteins) signals in positioning motor neuron cell bodies.
a role for Slit1 in corpus callosum development
Robo-2 (show ROBO2 Proteins)-mediated targeting of P2 axons along the dorsoventral axis of the OB is controlled by Slit-1 expression
This study demonistrated that production of IPCs is enhanced in Robo1 (show ROBO1 Proteins)/2 and Slit1/2 mutants, suggesting that Slit/Robo signaling modulates the transition between primary and intermediate progenitors.
Disruption of either the Robo1 (show ROBO1 Proteins) or Slit1 genes accelerates progression of thalamocortical axons in vivo.
Slit1 has a dual context-dependent role in thalamocortical axons formation
Robo1 (show ROBO1 Proteins) and Robo2 (show ROBO2 Proteins) are expressed in the nucleus origin of the tract of the postoptic commissure TPOC (nTPOC), while Slit expression domains flank the TPOC trajectory.
Nkx2.9 controls SACMN axon exit from the mammalian spinal cord by regulating Robo-Slit signaling
Data show that only Nck2 (show NCK2 Proteins) is required for the Slit1-induced changes in cortical neuron morphology in vitro.
These results indicate that Slit1/2 - Robo1 (show ROBO1 Proteins)/2 signaling is critical during the initial establishment of dopaminergic pathways, with roles in the dorsoventral positioning and precise pathfinding of these ascending longitudinal axons.
evidence showing that Slit1 and Slit2 proteins are selective inhibitors and repellents for dorsally projecting, but not for ventrally projecting, cranial motor axons
In fetal and embryonic stem cell cultures Slit-1 inhibited neurite outgrowth.
Slits are negative regulators of Sdf1 (show CXCL12 Proteins) and Cxcr4 (show CXCR4 Proteins) in breast cancer cells.
homolog of Drosophila slit\; may play a role in protein-protein interactions during midline formation in the central nervous system\; specifically expressed in fetal and adult forebrain neurons
slit homolog 1 (Drosophila)
, slit homolog 1
, slit homolog 1 protein-like
, slit homolog 1 protein
, multiple EGF-like domains protein 4
, multiple epidermal growth factor-like domains 4
, multiple epidermal growth factor-like domains protein 4