Browse our Metabotropic Glutamate Receptor 5 Proteins (GRM5)

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Glutamate Receptor, Metabotropic 5 Proteins (GRM5)
On are 7 Glutamate Receptor, Metabotropic 5 (GRM5) Proteins from 2 different suppliers available. Additionally we are shipping Metabotropic Glutamate Receptor 5 Antibodies (161) and Metabotropic Glutamate Receptor 5 Kits (18) and many more products for this protein. A total of 193 Metabotropic Glutamate Receptor 5 products are currently listed.
6430542K11Rik, AI850523, Glu5R, Gprc1e, mGlu5, mGlur5, mGluR5b
list all proteins Gene Name GeneID UniProt
GRM5 2915 P41594
Rat GRM5 GRM5 24418 P31424
GRM5 108071 Q3UVX5

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Metabotropic Glutamate Receptor 5 Proteins (GRM5) by Origin

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More Proteins for Metabotropic Glutamate Receptor 5 Interaction Partners

Human Glutamate Receptor, Metabotropic 5 (GRM5) interaction partners

  1. We report that expr (show PAM Proteins)ession of a key regulator of synaptic protein synthesis, the metabotropic glutamate receptor 5 (mGlu5) protein, is significantly reduced in both the brains of RS model mice and in the motor cortex of human RS autopsy samples.

  2. once at the inner nuclear membrane, mGluR5 is stably retained via interactions with chromatin and is perfectly positioned to regulate nucleoplasmic Ca(2 (show CA2 Proteins)+)in situ

  3. Overall, these data posit mGluR5 in key paralimbic areas as a strong determinant of the temperament trait novelty seeking. These data add to our understanding of how brain neurochemistry accounts for the variation in human behavior and strongly support further research on mGluR5 as a potential therapeutic target in neuropsychiatric disorders associated with abnormal novelty-seeking behaviors.

  4. Decrease of mGluR5 receptor density goes parallel with changes in enkephalin and substance P (show TAC1 Proteins) immunoreactivity in Huntington's disease

  5. The metabotropic glutamate (show GRIN1 Proteins) receptor subtype 5 (mGluR5) has been implicated in the pathophysiology of mood and anxiety disorders.

  6. The interaction between GRM5 and cellular prion protein (show PRNP Proteins) has a central role in transgenic mouse model of Alzheimer's disease pathogenesis.

  7. Data suggest that metabotropic glutamate receptors recycling is completely dependent on the activity of PP2A whereas, PP2B has partial effect on this process.

  8. findings provide evidence for decreased expression of metabotropic glutamate receptor 5 and its signaling components representing a key pathophysiological hallmark in autism spectrum disorder.

  9. Study provided evidence that protein expression of mGluR5 is significantly higher (total: 42%; monomer: 25%; dimer: 52%) in the hippocampal CA1 (show CA1 Proteins) region of schizophrenia subjects relative to healthy controls

  10. Results provide compelling evidence that mGluR5 regulation is altered in schizophrenia, likely contributing to the altered glutamatergic signaling that is associated with the disorder

Mouse (Murine) Glutamate Receptor, Metabotropic 5 (GRM5) interaction partners

  1. Here, we show in a mouse model of Rett syndrome (Mecp2 (show MECP2 Proteins) KO) that metabotropic glutamate receptor 5 (mGluR5)- and protein-synthesis-dependent synaptic plasticity are abnormal in the hippocampus.

  2. In a mouse model mimicking n-3 PUFA dietary deficiency during adolescence and adulthood, we found strong increases in anxiety and anhedonia which lead to decreases in specific cognitive functions in adulthood. We found that endocannabinoid/mGlu5-mediated LTD and NMDAR (show GRIN1 Proteins)-dependent LTP (show SCP2 Proteins) were lacking in adult n-3-deficient mice.

  3. findings demonstrate a causal role for increased mGluR5 signaling in driving striatal output abnormalities and behaviors with relevance to Obsessive Compulsive Disorder and show the tractability of acute mGluR5 inhibition to remedy circuit and behavioral abnormalities.

  4. our novel mGlu5 PAM (show PAM Proteins) improves Rett syndrome (RS)phenotypes and synaptic plasticity defects without evoking the overt adverse effects commonly associated with potentiation of mGlu5 signaling (i.e. seizures), or affecting cardiorespiratory defects in RS model mice. These findings provide strong support for the continued development of mGlu5 PAMs as potential therapeutic agents for use in RS, and, more broadly, for utility in

  5. This study used genetic mGluR5 mosaic animals to elucidate mGluR5s' cell-autonomous influences on the anatomical and functional development of cortical glutamatergic neurons.

  6. There was a general decline in mGluR5 brain expression and elevated levels of mGluR5 in older amyloid precursor protein (show APP Proteins) transgenic mice compared to wild-type.

  7. Here we identify mGluR1 (show GRM1 Proteins) and mGluR5 as key elements in the dynamic regulation of cholinergic synaptic inputs onto neurons of the TRN (show TNPO1 Proteins). Our findings highlight potential mechanisms that regulate cholinergic signaling in the mammalian brain.

  8. The present results showed that ER knockout alpha and beta male mice had lower striatal mGlu5 receptor binding and protein measured by Western blot.

  9. These results suggest that PrP(C (show PRNP Proteins))-mGluR5 form a functional response unit by which multiple ligands can trigger signaling. We propose that trafficking of PrP(C (show PRNP Proteins))-mGluR5 may modulate signaling intensity by different PrP(C (show PRNP Proteins)) ligands.

  10. GluD1 (show GLUD1 Proteins) interacts with mGlu5, and loss of GluD1 (show GLUD1 Proteins) impairs normal mGlu5 signaling potentially by dysregulating coupling to its effector.

Metabotropic Glutamate Receptor 5 (GRM5) Protein Profile

Protein Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Metabotropic Glutamate Receptor 5 (GRM5)

  • glutamate receptor, metabotropic 5 (GRM5)
  • glutamate receptor, metabotropic 5 (Grm5)
  • 6430542K11Rik protein
  • AI850523 protein
  • Glu5R protein
  • Gprc1e protein
  • mGlu5 protein
  • mGlur5 protein
  • mGluR5b protein

Protein level used designations for GRM5

metabotropic glutamate receptor 5 , metabotropic glutamate receptor 5 variant F , metabotropic glutamate receptor 5 variant G , metabotropic glutamate receptor 5 variant H , metabotropic glutamate receptor (mGluR5) , metabotropic glutamate receptor 5b , G protein coupled receptor, family C, group 1, member E , G protein-coupled receptor GRM5 , G protein-coupled receptor, family C, group 1, member E , metabotropic glutamate receptor subtype 5b , metabotropic glutamate receptor type 5

373933 Gallus gallus
2915 Homo sapiens
24418 Rattus norvegicus
108071 Mus musculus
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