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Human METAP1 Protein expressed in Human Cells - ABIN2002419
Addlagatta, Hu, Liu, Matthews: Structural basis for the functional differences between type I and type II human methionine aminopeptidases. in Biochemistry 2005
Show all 3 references for ABIN2002419
Human METAP1 Protein expressed in Escherichia coli (E. coli) - ABIN1098259
Dummitt, Fei, Chang: Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae. in Protein and peptide letters 2002
Show all 2 references for ABIN1098259
the substrate specificities of Escherichia coli MetAP1, human MetAP1, and human MetAP2 (show METAP2 Proteins) were systematically profiled
Data show that human methionine aminopeptidase 1 (MetAP1) fully rescued the slow growth phenotype associated with deletion of yeast MetAP1, suggesting that the yeast and human proteins may have similar roles in vivo.
results suggest that MetAP1 plays an important role in G(2)/M phase of the cell cycle and that it may serve as a promising target for the discovery and development of new anticancer agents
Human MetAP1 is distinct from other members of the MetAP superfamily in the number of metal ions employed and likely mechanism of catalysis.
Removes the N-terminal methionine from nascent proteins (By similarity).
methionyl aminopeptidase 1
, Methionine aminopeptidase 1
, MAP 1
, metAP 1
, methionine aminopeptidase 1
, peptidase M 1
, Putative methionine aminopeptidase 1 (MetAP 1) (Peptidase M 1)
, similar to methionyl aminopeptidase 1