METAP1 Protein (Fc Tag)
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- Target See all METAP1 Proteins
- METAP1 (Methionyl Aminopeptidase 1 (METAP1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This METAP1 protein is labelled with Fc Tag.
- Purpose
- Recombinant Human METAP1 Protein (Fc Tag)
- Sequence
- Met 1-Phe 272
- Characteristics
- A DNA sequence encoding the N-terminal domain (Met 1-Phe 272) of human METAP1 (NP_055958.2) was fused with the Fc region of human IgG1 at the N-terminus.
- Purity
- > 85 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product METAP1 Protein
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Methionyl Aminopeptidase 1 (METAP1) (AA 1-386) protein (His tag)
METAP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Methionyl Aminopeptidase 1 (METAP1) (AA 1-272) protein (GST tag)METAP1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Methionyl Aminopeptidase 1 (METAP1) (AA 2-386) protein (His tag)Crystallography grade METAP1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Methionyl Aminopeptidase 1 (METAP1) (AA 2-386) protein (His tag)Crystallography grade METAP1 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Methionyl Aminopeptidase 1 (METAP1) protein (Myc-DYKDDDDK Tag)METAP1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- METAP1 (Methionyl Aminopeptidase 1 (METAP1))
- Alternative Name
- METAP1 (METAP1 Products)
- Synonyms
- MGC64362 Protein, METAP1 Protein, metap1 Protein, DKFZp468B1413 Protein, LOC100228334 Protein, DDBDRAFT_0205763 Protein, DDBDRAFT_0235405 Protein, DDB_0205763 Protein, DDB_0235405 Protein, MAP1A Protein, MetAP1A Protein, 1700029C17Rik Protein, AW047992 Protein, mKIAA0094 Protein, Metap1 Protein, im:7047238 Protein, wu:fc84e12 Protein, zgc:110093 Protein, methionyl aminopeptidase 1 S homeolog Protein, methionyl aminopeptidase 1 Protein, methionine aminopeptidase 1 Protein, methionyl aminopeptidase 1 L homeolog Protein, metap1.S Protein, METAP1 Protein, metap1 Protein, Metap1 Protein, metap1.L Protein
- Background
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Background: Processing of the N-terminal initiator methionine or formylated methionine is an essential cellular process conserved from prokaryotes to eukaryotes. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. As a member of the M24 family of metalloproteases, METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents.
Synonym: Methionine aminopeptidase 1, MAP 1, MetAP 1, Peptidase M 1, METAP1,MAP1A,MetAP1A
- Molecular Weight
- 57 kDa
- NCBI Accession
- NP_055958
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
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