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Browse our Lysine (K)-Specific Demethylase 1A Proteins (KDM1A)

Full name:
Lysine (K)-Specific Demethylase 1A Proteins (KDM1A)
On www.antibodies-online.com are 9 Lysine (K)-Specific Demethylase 1A (KDM1A) Proteins from 6 different suppliers available. Additionally we are shipping Lysine (K)-Specific Demethylase 1A Antibodies (218) and Lysine (K)-Specific Demethylase 1A Kits (2) and many more products for this protein. A total of 244 Lysine (K)-Specific Demethylase 1A products are currently listed.
Synonyms:
1810043O07Rik, AA408884, Aof2, ARABIDOPSIS LYSINE-SPECIFIC HISTONE DEMETHYLASE, ATLSD1, ATSWP1, BHC110, D4Ertd478e, DKFZp459N2450, F23N19.21, F23N19_21, Kdm1, KDM1A, Lsd1, LSD1-like 1, LYSINE-SPECIFIC HISTONE DEMETHYLASE, mKIAA0601, RGD1562975, SWP1, wu:fb82e06, wu:fc51a02, wu:fj36a05, wu:fj66b06, xLSD1
list all proteins Gene Name GeneID UniProt
KDM1A 23028 O60341
KDM1A 99982 Q6ZQ88
Rat KDM1A KDM1A 500569  

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Lysine (K)-Specific Demethylase 1A Proteins (KDM1A) by Origin

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Top referenced Lysine (K)-Specific Demethylase 1A Proteins

  1. Human KDM1A Protein expressed in Baculovirus infected Insect Cells - ABIN2005873 : Kusaba, Ito, Morita, Iida, Sato, Fujimoto, Kawasaki, Tanaka, Hirochika, Nishimura, Tanaka: Rice NON-YELLOW COLORING1 is involved in light-harvesting complex II and grana degradation during leaf senescence. in The Plant cell 2007 (PubMed)

  2. Human KDM1A Protein expressed in Human - ABIN2714763 : Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014 (PubMed)

More Proteins for Lysine (K)-Specific Demethylase 1A Interaction Partners

Human Lysine (K)-Specific Demethylase 1A (KDM1A) interaction partners

  1. lysine-specific demethylase (show MBD2 Proteins)-1 is an important oncogene (show RAB1A Proteins) in gastric cancer, and lysine-specific demethylase (show MBD2 Proteins)-1-mediated epigenetic repression of KLF2 (show KLF2 Proteins) plays a critical role in gastric cancer development and progression.

  2. The data indicate that LSD1 acts as an epigenetic regulator of epithelial-mesenchymal transition and contributes to the metastasis of ovarian cancer.

  3. We also uncovered the suppression of the p53 (show TP53 Proteins) signaling pathway that mediated the activity of USP7 (show USP7 Proteins) and LSD1. Furthermore, USP7 (show USP7 Proteins) and LSD1 expression levels were higher in the 150 glioma patients than these levels in normal brain tissues and were correlated with glioma progression.

  4. LSD1 knockdown affected the fuction of gastric cancer MKN-28 cell line.

  5. our findings showed that miR (show MLXIP Proteins)-708 might serve as an antioncogene by directly targeting LSD1, through promoting cell growth and cell invasion.

  6. Data show that lysine-specific demethylase (show MBD2 Proteins) 1 (LSD1) is a drug target for mixed lineage leukemia (MLL (show MLL Proteins))-rearranged leukemia, and LSD1 inhibitors are potential therapeutics for the malignancy.

  7. Results show that LSD1 is upregulated in human prostate cancer and plays an oncogenic role.

  8. Authors found positive correlations between LSD1 expression and other proteins: epithelial-mesenchymal transition markers, C-myc (show MYC Proteins) and cyclin (show PCNA Proteins)-related proteins. Inhibiting LSD1 expression in vitro impaired the proliferation and invasiveness of GBC cells and also downregulated c-myc (show MYC Proteins) expression and consequently inhibited GBC cell proliferation.

  9. These results highlight a novel mechanism regulating LSD1 expression and identify LSD1 as a promising therapeutic target for treating metastatic ovarian cancer driven by EGF (show EGF Proteins) signaling.

  10. these data suggest that KDM1A likely contains a histone H3 (show HIST3H3 Proteins) secondary specificity element on the enzyme surface that contributes significantly to its recognition of substrates and products.

Mouse (Murine) Lysine (K)-Specific Demethylase 1A (KDM1A) interaction partners

  1. RIP140 (show NRIP1 Proteins) protects LSD1's catalytic domain and antagonizes its Jade-2 (show PHF15 Proteins)-mediated ubiquitination and degradation.

  2. Loss of maternal LSD1/KDM1A in mice results in embryonic arrest at the 1-2 cell stage, with arrested embryos failing to undergo the maternal-to-zygotic transition.

  3. KDM1A plays critical roles in establishing the correct epigenetic landscape of the zygote upon fertilization, in preserving genome integrity and in initiating new patterns of genome expression that drive early mouse development.

  4. Data show that CCAAT-enhancer-binding protein-alpha (C/EBPalpha (show CEBPA Proteins)) directly regulates Kruppel-like factor 4 (Klf4 (show KLF4 Proteins)) expression and increasing the levels of histone demethylase (show MBD2 Proteins) Lsd1 and transcription factor Brd4 (show BRD4 Proteins) in B cell.

  5. Deletion or reduction of isoform neuro LSD1 translates into decreased levels of activating histone marks at egr1 and c-fos promoters, dampening their psychosocial stress-induced transcription and resulting in low anxiety-like behavior.

  6. Rcor2 (show Rcor2 Proteins), a co-repressor of LSD1, controls neurogenesis in the developing mouse brain.

  7. GFI1 (show ZNF163 Proteins) proteins recruit the chromatin-modifying protein LSD1, a member of the CoREST (show Rcor2 Proteins) repressive complex, to epigenetically silence the endothelial program in haemogenic endothelium and allow the emergence of blood cells

  8. LSD1 is essential for oocyte meiotic progression by upregulating CDC25B (show CDC25B Proteins) expression.

  9. This study described how neuronal activity controls the neurospecific splicing of the epigenetic co-repressor LSD1 in mammalian nervous system.

  10. LSD1 mediates erythroid differentiation, via epigenetic modification of the GATA-2 (show GATA2 Proteins) locus.

Zebrafish Lysine (K)-Specific Demethylase 1A (KDM1A) interaction partners

  1. LSD1 plays a critical role in hair cell regeneration and might represent a novel biomarker and potential therapeutic approach for the treatment of hearing loss.

  2. results suggest that the LSD1-dependent shutdown of Etv2 (show ETV2 Proteins) gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation

  3. Results indicate that LSD1 demethylase (show MBD2 Proteins) activity is required for neuromast development in zebrafish larvae.

Pig (Porcine) Lysine (K)-Specific Demethylase 1A (KDM1A) interaction partners

  1. LSD1 gene has two transcripts and is expressed in various tissues and relatively higher in ovary, kidney, and spleen.

Arabidopsis thaliana Lysine (K)-Specific Demethylase 1A (KDM1A) interaction partners

  1. LSD1, EDS1, and PAD4 (show PADI4 Proteins) participate in the regulation of various molecular and physiological processes that influence Arabidopsis fitness.

  2. AtSWP1 and AtCZS represent two main components of a co-repressor complex that fine tunes flowering and is unique to plants.

  3. AtLSD1, similar to HsLSD1, has demethylase (show MBD2 Proteins) activity toward mono- and dimethylated Lys4 but not dimethylated Lys9 and Lys27 of histone 3. [LSD1]

Lysine (K)-Specific Demethylase 1A (KDM1A) Protein Profile

Protein Summary

This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Lysine (K)-Specific Demethylase 1A (KDM1A)

  • amine oxidase (flavin containing) domain 2 (AOF2)
  • lysine (K)-specific demethylase 1 (KDM1)
  • lysine (K)-specific demethylase 1A (KDM1A)
  • lysine (K)-specific demethylase 1A (kdm1a)
  • lysine (K)-specific demethylase 1A (Kdm1a)
  • lysine (K)-specific demethylase 1a (kdm1a)
  • Lysine-specific histone demethylase 1-1 (LDL1)
  • 1810043O07Rik protein
  • AA408884 protein
  • Aof2 protein
  • ARABIDOPSIS LYSINE-SPECIFIC HISTONE DEMETHYLASE protein
  • ATLSD1 protein
  • ATSWP1 protein
  • BHC110 protein
  • D4Ertd478e protein
  • DKFZp459N2450 protein
  • F23N19.21 protein
  • F23N19_21 protein
  • Kdm1 protein
  • KDM1A protein
  • Lsd1 protein
  • LSD1-like 1 protein
  • LYSINE-SPECIFIC HISTONE DEMETHYLASE protein
  • mKIAA0601 protein
  • RGD1562975 protein
  • SWP1 protein
  • wu:fb82e06 protein
  • wu:fc51a02 protein
  • wu:fj36a05 protein
  • wu:fj66b06 protein
  • xLSD1 protein

Protein level used designations for KDM1A

amine oxidase (flavin containing) domain 2 , lysine (K)-specific demethylase 1 , lysine (K)-specific demethylase 1A , BRAF35-HDAC complex protein BHC110 , FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit , flavin-containing amine oxidase domain-containing protein 2 , lysine-specific histone demethylase 1 , lysine-specific histone demethylase 1A , neuroprotective protein 3 , lsd1

GENE ID SPECIES
419571 Gallus gallus
456614 Pan troglodytes
718609 Macaca mulatta
100171870 Pongo abelii
100216250 Xenopus (Silurana) tropicalis
100557968 Anolis carolinensis
23028 Homo sapiens
99982 Mus musculus
478193 Canis lupus familiaris
500569 Rattus norvegicus
558450 Danio rerio
532997 Bos taurus
100127157 Sus scrofa
842582 Arabidopsis thaliana
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