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Human KDM1A Protein expressed in HEK-293 Cells - ABIN2714763
Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014
we show that KDM1A promotes cancer metastasis in non-small cell lung cancer cells by repressing TIMP3 (tissue inhibitor of metalloproteinase 3 (show TIMP3 Proteins)) expression.
Results show that LSD1 expression was upregulated in breast carcinoma and, induced EMT (show ITK Proteins) in breast cancer cells through demethylation of H3K4me at the E-cadherin (show CDH1 Proteins) promoter. Its phosphorylation at Ser112 is crucial for these functions.
LSD1 directly associates with the promoter of the HEYL (show HEYL Proteins) gene.
LSD1 controls autophagy in neuroblastoma (show ARHGEF16 Proteins) cells through SESN2 (show SESN2 Proteins) transcription regulation.
Mechanistic investigations showed that LINC01133 could interact with EZH2 (show EZH2 Proteins), LSD1 and recruit them to KLF2 (show KLF2 Proteins), P21 (show CDKN1A Proteins) or E-cadherin (show CDH1 Proteins) promoter regions to repress their transcription.
estrogen induced TFPI-2 (show TFPI2 Proteins) expression in MCF7 cells is mediated by ERalpha (show ESR1 Proteins) and also by the action of LSD1.
CENPE (show CENPE Proteins) was regulated by the co-binding of LSD1 and AR to its promoter, which was associated with loss of RB1 (show RB1 Proteins) in CRPC.
RBPJ (show RBPJ Proteins) interacts with L3MBTL3 (show L3MBTL3 Proteins) to promote repression of Notch (show NOTCH1 Proteins) signaling via histone demethylase (show MBD2 Proteins) KDM1A.
High LSD1 expression is associated with small-cell lung cancer.
The role of LSD1 in the EMT (show ITK Proteins) process.
LSD1 is required for the timely expression of MyoD (show MYOD1 Proteins) in limb buds.
Lsd1 is a key regulator of gene expression and metabolic function in brown adipose tissue.
The Demethylase (show MBD2 Proteins) Activity of LSD1 Is Required for Brown Adipogenesis.
through interaction with Zfp516, LSD1 is recruited to UCP1 (show UCP1 Proteins) and other brown adipose tissue-enriched genes.
Study propose that KDM1A is a key regulator of spermatogenesis and germ cell maintenance in the mouse.
This study demonstrates that the FGF19 (show FGF19 Proteins)-SHP (show LAMC1 Proteins)-LSD1 axis maintains homeostasis by suppressing unnecessary autophagic breakdown of cellular components, including lipids, under nutrient-rich postprandial conditions.
This analysis identified that LSD1 is the only lysine demethylase (show MBD2 Proteins) required for myogenic differentiation and that KDM3B (show KDM3B Proteins), KDM6A (show KDM6A Proteins), and KDM8 (show JMJD5 Proteins) are the candidate lysine demethylases required for osteoblast differentiation.
Class I KDACs facilitate Dex-induced transcriptional repression by suppressing LSD1 complex activity at selected target gene promoters
The study describes an interaction network of STAT5a (show STAT5A Proteins)/LSD1/HDAC3 (show HDAC3 Proteins) and a dual function of LSD1/HDAC3 (show HDAC3 Proteins) on STAT5a (show STAT5A Proteins)-dependent transcription, defined by protein-protein interactions, genomic binding localization/affinity and motifs.
that nuclear GSK3beta- and USP22 (show USP22 Proteins)-mediated KDM1A stabilization is essential for glioblastoma tumorigenesis
LSD1 plays a critical role in hair cell regeneration and might represent a novel biomarker and potential therapeutic approach for the treatment of hearing loss.
results suggest that the LSD1-dependent shutdown of Etv2 (show ETV2 Proteins) gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation
Results indicate that LSD1 demethylase (show MBD2 Proteins) activity is required for neuromast development in zebrafish larvae.
LSD1 gene has two transcripts and is expressed in various tissues and relatively higher in ovary, kidney, and spleen.
LSD1, EDS1, and PAD4 (show PADI4 Proteins) participate in the regulation of various molecular and physiological processes that influence Arabidopsis fitness.
AtSWP1 and AtCZS represent two main components of a co-repressor complex that fine tunes flowering and is unique to plants.
AtLSD1, similar to HsLSD1, has demethylase (show MBD2 Proteins) activity toward mono- and dimethylated Lys4 but not dimethylated Lys9 and Lys27 of histone 3. [LSD1]
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
amine oxidase (flavin containing) domain 2
, lysine (K)-specific demethylase 1
, lysine (K)-specific demethylase 1A
, BRAF35-HDAC complex protein BHC110
, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
, flavin-containing amine oxidase domain-containing protein 2
, lysine-specific histone demethylase 1
, lysine-specific histone demethylase 1A
, neuroprotective protein 3