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Browse our anti-F2RL1 (F2RL1) Antibodies

Full name:
anti-Coagulation Factor II (thrombin) Receptor-Like 1 Antibodies (F2RL1)
On are 28 Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) Antibodies from 11 different suppliers available. Additionally we are shipping F2RL1 Kits (30) and F2RL1 Proteins (7) and many more products for this protein. A total of 71 F2RL1 products are currently listed.
Gpcr11, GPR11, Par-2, Par2
list all antibodies Gene Name GeneID UniProt
F2RL1 2150 P55085
F2RL1 14063 P55086
F2RL1 116677 Q63645

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Most Popular Reactivities for anti-F2RL1 (F2RL1) Antibodies

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anti-Human F2RL1 Antibodies:

anti-Mouse (Murine) F2RL1 Antibodies:

anti-Rat (Rattus) F2RL1 Antibodies:

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Top referenced anti-F2RL1 Antibodies

  1. Human Polyclonal F2RL1 Primary Antibody for WB - ABIN2788314 : Yau, Liu, Fairlie: Toward drugs for protease-activated receptor 2 (PAR2). in Journal of medicinal chemistry 2013 (PubMed)

More Antibodies against F2RL1 Interaction Partners

Human Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) interaction partners

  1. Study suggests that deregulated pericellular matriptase (show ST14 Antibodies) activity in OSCC may transactivate PAR-2 on fibroblasts in the surrounding tissue and thus promote their recruitment to the perimeter of the tumor, contributing to a microenvironement that favors tumor growth of oral squamous cell carcinoma.

  2. Study demonstrates that AHRR (show CYP1A1 Antibodies) and F2RL3 (show F2RL3 Antibodies) methylation are strong predictors individually for lung cancer development.

  3. PAR2 activation promoted obesity.

  4. Data suggest that thrombin (show F2 Antibodies) can directly activate PAR2 vasorelaxation, signal transduction (stimulating both calcium and MAP kinase (show MAPK1 Antibodies) responses), and triggering beta-arrestin recruitment (both beta-arrestin 1 (show ARRB1 Antibodies) and 2).

  5. Activation of PAR-2 by SLIGRL, a PAR-2 specific ligand, leads to dual phosphorylation of both catalytic sites but primarily regulated eNOS (show NOS3 Antibodies)-Thr (show TRH Antibodies)-495 phosphorylation with no change in nitric oxide production.

  6. Stimulation of PAR-2 activates Nf-kappaB (show NFKB1 Antibodies) signaling, resulting in RelA (show NFkBP65 Antibodies) nuclear translocation and enhanced expression of pro-inflammatory mRNAs in oral squamous cell carcinoma.

  7. This study provides evidence for the major role of PAR-2 in the pathogenesis of gastroesophageal reflux disease (GERD) and GERD-associated mucosal alterations.

  8. PAR-2 expression is increased on CD14 (show NDUFA2 Antibodies)++CD16 (show CD16 Antibodies)+ monocytes in the peripheral blood of subjects with severe asthma and may be a biomarker of asthma severity.

  9. PAR-2 contributes to the progression of pulmonary fibrosis, and targeting PAR-2 may be a promising therapeutic strategy for treating pulmonary fibrosis.

  10. Binding of the PH domain of PAR-2 enables breast cancer growth and extravillous trophoblast invasion.

Mouse (Murine) Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) interaction partners

  1. The levels of miR (show MLXIP Antibodies)-223, miR (show MLXIP Antibodies)-339 and miR (show MLXIP Antibodies)-21, which are associated with platelet activation, were elevated in pooled mouse plasma exosomes before thrombosis and enriched in thrombin (show F2 Antibodies)-stimulated platelet-derived exosomes in vitro.

  2. Neutrophil elastase (show ELANE Antibodies) induced acute inflammation and pain in knee joints of mice. These changes are PAR2-dependent and appear to involve activation of a p44 (show GTF2H4 Antibodies)/42 MAPK (show MAPK1 Antibodies) pathway. Blocking neutrophil elastase (show ELANE Antibodies), PAR2 and p44 (show GTF2H4 Antibodies)/42 MAPK (show MAPK1 Antibodies) activity can reduce inflammation and pain, suggesting their utility as therapeutic targets.

  3. Reductions in astrogliosis, inflammation and neuromotor recovery observed in protease Activated Receptor 2 knockout mice after spinal cord injury suggests that this receptor and its agonists represent new drug targets to foster neuromotor recovery.

  4. Stimulation of PAR-2 activates Nf-kappaB (show NFKB1 Antibodies) signaling, resulting in RelA (show NFkBP65 Antibodies) nuclear translocation and enhanced expression of pro-inflammatory mRNAs in oral squamous cell carcinoma.

  5. Tryptase (show TPSAB1 Antibodies) and protease-activated receptor-2 stimulate scratching behavior in a murine model of ovalbumin (show OVA Antibodies)-induced atopic-like dermatitis

  6. This study reveals, for the first time, an important role for PAR2 in allergic lung inflammation

  7. HAI-1 (show SPINT1 Antibodies) may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2-dependent p38 mitogen-activated protein kinase (show MAPK14 Antibodies) signaling.

  8. PAR2 activation through endogenous mast cell tryptase activity could be required, at least partially, to mediate CCL11 (show CCL11 Antibodies)-induced eosinophil migration

  9. These studies identify the thrombin receptor (show F2R Antibodies) as a powerful extracellular regulatory switch that could be readily targeted to improve myelin production in the face of white matter injury and disease.

  10. PAR2 knockout prevented bone cancer-related pain behaviours and associated neurochemical changes in dorsal root ganglion and dorsal horn.

Cow (Bovine) Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) interaction partners

  1. PAR1 (show F2R Antibodies) and PAR2 regulate endothelial NO synthase (show NOS Antibodies) phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.

F2RL1 Antigen Profile

Antigen Summary

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.

Alternative names and synonyms associated with F2RL1

  • Proteinase-activated receptor 2 (par2) antibody
  • coagulation factor II (thrombin) receptor-like 1 (F2RL1) antibody
  • coagulation factor II (thrombin) receptor-like 1 (F2rl1) antibody
  • Gpcr11 antibody
  • GPR11 antibody
  • Par-2 antibody
  • Par2 antibody

Protein level used designations for F2RL1

Proteinase-activated receptor 2 , G-protein coupled receptor 11 , coagulation factor II receptor-like 1 , protease-activated receptor 2 , proteinase-activated receptor 2 , thrombin receptor-like 1 , Protease-activated receptor-2 , proteinase-activated receptor-2 , Proteinase-activated receptor-2 G protein-coupled receptor 11 , Proteinase-activated receptor-2, G protein-coupled receptor 11 , PAR-2

100195488 Salmo salar
2150 Homo sapiens
14063 Mus musculus
116677 Rattus norvegicus
526525 Bos taurus
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