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anti-Human F2RL1 Antibodies:
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Human Monoclonal F2RL1 Primary Antibody for FACS - ABIN4898819
Amiable, Tat, Lajeunesse, Duval, Pelletier, Martel-Pelletier, Boileau: Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts. in Bone 2009
Show all 2 Pubmed References
Dog (Canine) Polyclonal F2RL1 Primary Antibody for WB - ABIN2788314
Yau, Liu, Fairlie: Toward drugs for protease-activated receptor 2 (PAR2). in Journal of medicinal chemistry 2013
TF-induced microvessel stabilization is regulated via PAR2-SMAD3 (show SMAD3 Antibodies) that is indispensable for the maintenance of vascular integrity.
PAR-2- and PAR-1 (show MARK2 Antibodies)-mediated TNF-alpha (show TNF Antibodies) release from monocytes suggests that these unique protease receptors are involved in the pathogenesis of inflammation.
Results indicate that chymotrypsin-like serine protease (show F2 Antibodies) enhances soluble fms-like tyrosine kinase 1 (show FLT1 Antibodies) production through protease-activated receptor-2 in trophoblast cells and thus plays an important additional role in preeclampsia pathogenesis.
crystal structures of PAR2 in complex with two distinct antagonists and a blocking antibody
PAR-2 plays an important role in the progression of ovarian clear cell carcinoma.
Data suggest activation of PAR2 via FVIIA/TF signaling activates PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling, inactivates GSK3b (show GSK3b Antibodies) signaling, leads to accumulation of beta-catenin (show CTNNB1 Antibodies), and promotes tumor cell migration/invasion. (PAR2 = protease-activated receptor 2; FVIIA = coagulation factor VIIa; TF = tissue factor/thromboplastin (show F3 Antibodies); PI3K (show PIK3CA Antibodies) = phosphatidylinositol 3-kinase; AKT (show AKT1 Antibodies) = proto-oncogene (show RAB1A Antibodies) protein c (show PROC Antibodies)-akt (show AKT1 Antibodies); GSK3b (show GSK3b Antibodies) = glycogen synthase kinase 3 beta (show GSK3b Antibodies))
PAR2 modulation was sufficient to induce islet cell transdifferentiation in the absence of beta-cells.
Studies provide increasing evidence that PAR2 plays a significant role in inflammatory diseases both in the periphery and in the CNS. There is a clear similarity between PAR2 expression and activation on cells of the immune system and those cell types that are proposed to play a role within the CNS, astrocytes and microglia. [review]
Results show that PAR2 in hepatic stellate cells plays a crucial role in promoting hepatocellular carcinoma growth presumably by mediating migration and secretion of pro-angiogenic and pro-mitotic factors.
Data highlight functional differences in proliferation and barrier integrity between dark keratinocytes and fair keratinocytes that are partly associated with their differential expression of PAR1 (show MARK2 Antibodies) and PAR2.
thrombin (show F2 Antibodies) has a role in diet-induced obesity through fibrin-driven inflammation
Our results are suggestive that PAR2 inhibition may play a role in the treatment of diseases with increased inflammatory responses in renal systems
PAR2/GSK3beta (show GSK3b Antibodies) is a novel pathway that plays a critical role in the regulation of stem/progenitor cell survival and proliferation in normal colon crypts and colon cancer.
Enhanced FXa (show F10 Antibodies) and PAR2 exacerbate DN and that both are promising targets for preventing diabetic nephropathy.
PAR2 is critically important in the pathogenesis of adenine-induced tubular injury
The levels of miR (show MLXIP Antibodies)-223, miR (show MLXIP Antibodies)-339 and miR (show MLXIP Antibodies)-21, which are associated with platelet activation, were elevated in pooled mouse plasma exosomes before thrombosis and enriched in thrombin (show F2 Antibodies)-stimulated platelet-derived exosomes in vitro.
Neutrophil elastase (show ELANE Antibodies) induced acute inflammation and pain in knee joints of mice. These changes are PAR2-dependent and appear to involve activation of a p44 (show GTF2H4 Antibodies)/42 MAPK (show MAPK1 Antibodies) pathway. Blocking neutrophil elastase (show ELANE Antibodies), PAR2 and p44 (show GTF2H4 Antibodies)/42 MAPK (show MAPK1 Antibodies) activity can reduce inflammation and pain, suggesting their utility as therapeutic targets.
Reductions in astrogliosis, inflammation and neuromotor recovery observed in protease Activated Receptor 2 knockout mice after spinal cord injury suggests that this receptor and its agonists represent new drug targets to foster neuromotor recovery.
Stimulation of PAR-2 activates Nf-kappaB (show NFKB1 Antibodies) signaling, resulting in RelA (show NFkBP65 Antibodies) nuclear translocation and enhanced expression of pro-inflammatory mRNAs in oral squamous cell carcinoma.
PAR1 (show F2R Antibodies) and PAR2 regulate endothelial NO synthase (show NOS Antibodies) phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.
Proteinase-activated receptor 2
, G-protein coupled receptor 11
, coagulation factor II receptor-like 1
, protease-activated receptor 2
, proteinase-activated receptor 2
, thrombin receptor-like 1
, Protease-activated receptor-2
, proteinase-activated receptor-2
, Proteinase-activated receptor-2 G protein-coupled receptor 11
, Proteinase-activated receptor-2, G protein-coupled receptor 11