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Arginine (di)methylated human leukocyte antigen class I peptides, which are asymmetrically dimethylated, most likely by CARM1, are favorably presented by HLA-B*07.
This study demonstrated that the expression of a single human class I MHC molecule, independent of persistent virus infection, influences the extent of sub frequent chronic neuronal injury or repair in the absence of a class II MHC immune response.
The HLA-B*50 allele was associated with conversion to myasthenia gravis generalized disease in patients with pure ocular symptoms at disease onset.
findings demonstrate that gliadins contain epitopes that elicit CD8 (show CD8A ELISA Kits)+ T cell responses restricted by HLA class I (show MICA ELISA Kits) A*0101 and B*0801 molecules
The HLA-B*42, HLA-C*17, HLA-DPA1*03, and HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 genotype with the nonallergic phenotype.
There was no increased risk of rheumatoid arthritis in mothers of children with aspartic acid at position 9 of HLA-B.
HLA-B*15:13 and HLA-B*15:02 are associated with phenytoin-induced severe cutaneous adverse reactions in a Malay population.
The study found a strong association between the presence of HLA-B27 and the diagnosis of axial spondyloarthritis (axSpA) and ankylosing spondylitis (AS), but the HLA-B15 (show NDUFB4 ELISA Kits) is also significantly associated with all subtypes of the disease, predominantly with peripheral spondyloarthritis (pSpA). Additionally, HLA-DR1 (show DR1 ELISA Kits) and DR4 were associated in a cohort of patients with SpA (show FASL ELISA Kits) from Colombia.
selecting a MICA (show MICA ELISA Kits)-matched donor significantly influences key clinical outcomes of HCT in which a marked reduction of GVHD is paramount. The tight linkage disequilibrium between MICA (show MICA ELISA Kits) and HLA-B renders identifying a MICA (show MICA ELISA Kits)-matched donor readily feasible in clinical practice.
HLA-B51 is a primary association marker in predisposition to Behcet disease, with IL-23R and IL12A being the additional strongest loci.
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
major histocompatibility complex, class I, B
, HLA class I histocompatibility antigen, B alpha chain
, MHC Class I HLA heavy chain
, MHC HLA-B cell surface glycoprotein
, MHC HLA-B transmembrane glycoprotein
, MHC class I antigen GN00104
, MHC class I antigen HLA-B heavy chain
, MHC class I antigen SHCHA
, leukocyte antigen class I-B
, lymphocyte antigen