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HLA-B Products

(Major Histocompatibility Complex, Class I, B (HLA-B))

Categories

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008].

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Featured HLA-B Categories

HLA-B Antibodies

High quality antibodies with extensive validation data.

HLA-B ELISA Kits

Reliable ELISA kits for a wide range of species.

HLA-B Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HLA-B Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, FACS, ICC, IHC, WB
Validations
  • (7)
Cat. No. ABIN5542339
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, WB
Validations
  • (4)
Cat. No. ABIN7256404
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN7155621
Quantity 100 μg
Datasheet Datasheet

Recommended HLA-B ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957622
Quantity 96 tests
Datasheet Datasheet

Recommended HLA-B Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN6386493
Quantity 2 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5712958
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7123829
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our HLA-B products

Lorente, Infantes, Abia, Barnea, Beer, García, Lasala, Jiménez, Mir, Morreale, Admon, López et al.: "A viral, transporter associated with antigen processing (TAP)-independent, high affinity ligand with alternative interactions endogenously presented by the nonclassical human leukocyte antigen E ..." in: The Journal of biological chemistry, Vol. 287, Issue 42, pp. 34895-903, (2012) (PubMed).

Lorente, García, López: "Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells." in: The Journal of biological chemistry, Vol. 286, Issue 44, pp. 38054-9, (2011) (PubMed).

Lorente, Infantes, Barnea, Beer, García, Lasala, Jiménez, Vilches, Lemonnier, Admon, López: "Multiple viral ligands naturally presented by different class I molecules in transporter antigen processing-deficient vaccinia virus-infected cells." in: Journal of virology, Vol. 86, Issue 1, pp. 527-41, (2011) (PubMed).

Lin, Tokunaga, Tanaka, Nakajima, Imanishi, Kashiwase, Bannai, Mizuno, Akaza, Tadokoro, Shibata, Juji: "Further molecular diversity in the HLA-B15 group." in: Tissue antigens, Vol. 47, Issue 4, pp. 265-74, (1996) (PubMed).

Hildebrand, Domena, Shen, Lau, Terasaki, Bunce, Marsh, Guttridge, Bias, Parham: "HLA-B15: a widespread and diverse family of HLA-B alleles." in: Tissue antigens, Vol. 43, Issue 4, pp. 209-18, (1994) (PubMed).

Little, Parham: "The HLA-Bw75 subtype of B15: molecular characterization and comparison with crossreacting antigens." in: Tissue antigens, Vol. 38, Issue 4, pp. 186-90, (1992) (PubMed).

Madrigal, Belich, Hildebrand, Benjamin, Little, Zemmour, Ennis, Ward, Petzl-Erler, du Toit: "Distinctive HLA-A,B antigens of black populations formed by interallelic conversion." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 10, pp. 3411-5, (1992) (PubMed).

Watkins, McAdam, Liu, Strang, Milford, Levine, Garber, Dogon, Lord, Ghim: "New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci." in: Nature, Vol. 357, Issue 6376, pp. 329-33, (1992) (PubMed).

Synonyms and alternative names related to HLA-B

major histocompatibility complex, class I, B (HLA-B), major histocompatibility complex, class I, B (BOLA-B), major histocompatibility complex, class I, B (MAMU-B18), major histocompatibility complex, class I, B (DKFZP469N1225), major histocompatibility complex nonclassical class Ib L homeolog (mhc1b.L), AS, HLAB, mhc1b, SPDA1

Protein level used designations for HLA-B

  • HLA class I histocompatibility antigen, B alpha chain
  • MHC Class I HLA heavy chain
  • MHC HLA-B cell surface glycoprotein
  • MHC HLA-B transmembrane glycoprotein
  • MHC class I antigen GN00104
  • MHC class I antigen HLA-B heavy chain
  • MHC class I antigen SHCHA
  • leukocyte antigen class I-B
  • lymphocyte antigen
  • major histocompatibility complex, class I, B
  • major histocompatibility complex nonclassical class Ib L homeolog
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