Browse our HLA-B Proteins (HLA-B)

On www.antibodies-online.com are 76 Major Histocompatibility Complex, Class I, B (HLA-B) Proteins from 4 different suppliers available. Additionally we are shipping HLA-B Antibodies (126) and HLA-B Kits (6) and many more products for this protein. A total of 213 HLA-B products are currently listed.
Synonyms:
AS, HLAB, SPDA1
list all proteins Gene Name GeneID UniProt
HLA-B 3106 P01889

HLA-B Proteins (HLA-B) by Origin

More Proteins for HLA-B Interaction Partners

Human Major Histocompatibility Complex, Class I, B (HLA-B) interaction partners

  1. The HLA-B*50 allele was associated with conversion to myasthenia gravis generalized disease in patients with pure ocular symptoms at disease onset.

  2. findings demonstrate that gliadins contain epitopes that elicit CD8 (show CD8A Proteins)+ T cell responses restricted by HLA class I (show MICA Proteins) A*0101 and B*0801 molecules

  3. The HLA-B*42, HLA-C*17, HLA-DPA1*03, and HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 genotype with the nonallergic phenotype.

  4. There was no increased risk of rheumatoid arthritis in mothers of children with aspartic acid at position 9 of HLA-B.

  5. HLA-B*15:13 and HLA-B*15:02 are associated with phenytoin-induced severe cutaneous adverse reactions in a Malay population.

  6. The study found a strong association between the presence of HLA-B27 and the diagnosis of axial spondyloarthritis (axSpA) and ankylosing spondylitis (AS), but the HLA-B15 (show NDUFB4 Proteins) is also significantly associated with all subtypes of the disease, predominantly with peripheral spondyloarthritis (pSpA). Additionally, HLA-DR1 (show DR1 Proteins) and DR4 (show HLADRB4 Proteins) were associated in a cohort of patients with SpA (show FASL Proteins) from Colombia.

  7. selecting a MICA (show MICA Proteins)-matched donor significantly influences key clinical outcomes of HCT in which a marked reduction of GVHD is paramount. The tight linkage disequilibrium between MICA (show MICA Proteins) and HLA-B renders identifying a MICA (show MICA Proteins)-matched donor readily feasible in clinical practice.

  8. HLA-B51 is a primary association marker in predisposition to Behcet disease, with IL-23R and IL12A being the additional strongest loci.

  9. Here we define the nature and extent of the variation in 3,489 HLA-A, 4,356 HLA-B and 3,111 HLA-C alleles. The common alleles of human populations comprise 42 core alleles, which represent all selected polymorphism, and recombinants that have assorted this polymorphism

  10. It was shown that the HLA-A*34 allele is a risk factor for recurrent spontaneous abortion, while the HLA-A*24 and HLA-B*35 alleles are associated with protection, and no allele of the DRB1 locus was associated with recurrent spontaneous abortion

HLA-B Protein Profile

Protein Summary

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

Alternative names and synonyms associated with HLA-B

  • major histocompatibility complex, class I, B (BOLA-B)
  • major histocompatibility complex, class I, B (MAMU-B18)
  • major histocompatibility complex, class I, B (DKFZP469N1225)
  • major histocompatibility complex, class I, B (HLA-B)
  • AS protein
  • HLAB protein
  • SPDA1 protein

Protein level used designations for HLA-B

major histocompatibility complex, class I, B , HLA class I histocompatibility antigen, B alpha chain , MHC Class I HLA heavy chain , MHC HLA-B cell surface glycoprotein , MHC HLA-B transmembrane glycoprotein , MHC class I antigen GN00104 , MHC class I antigen HLA-B heavy chain , MHC class I antigen SHCHA , leukocyte antigen class I-B , lymphocyte antigen

GENE ID SPECIES
282156 Bos taurus
100141394 Macaca mulatta
100173276 Pongo abelii
3106 Homo sapiens
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