Browse our Cyclin-Dependent Kinase 11B Proteins (CDK11B)

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Cyclin-Dependent Kinase 11B Proteins (CDK11B)
On are 6 Cyclin-Dependent Kinase 11B (CDK11B) Proteins from 4 different suppliers available. Additionally we are shipping Cyclin-Dependent Kinase 11B Antibodies (33) and Cyclin-Dependent Kinase 11B Kits (1) and many more products for this protein. A total of 45 Cyclin-Dependent Kinase 11B products are currently listed.
2700084L06Rik, AA989746, AI845279, AW228747, Cdc2l1, Cdc2l2, Cdc2l6, Cdc11b, Cdk11, CDK11-p46, CDK11-p58, CDK11-p110, CDK11B, CLK-1, mKIAA1028, p58, p58CDC2L1, p58CLK-1, PK58
list all proteins Gene Name GeneID UniProt
CDK11B 984 P21127
CDK11B 12537 P24788
CDK11B 252879  

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Human Cyclin-Dependent Kinase 11B (CDK11B) interaction partners

  1. we showed high expression of CDK11 in metastatic and recurrent ovarian cancer and demonstrated that CDK11 is essential for ovarian cancer cell growth and survival in vitro and in vivo.

  2. CDK11 was found associated with the TREX/THOC, which recruited this kinase to DNA. Once at the viral genome, CDK11 phosphorylated serines at position 2 in the CTD of RNAPII, which increased levels of cleavage and polyadenylation factors at the HIV 3' end. In its absence, cleavage of viral transcripts was greatly attenuated.

  3. Real-time PCR and dual-luciferase assay showed CDK11(p58) inhibited the mRNA levels of VEGF and the promoter activity of VEGF

  4. Hepsin (show HPN Proteins) suppressed CDK11p58 internal ribosome entry site activity in prostate cancer cells by modulating UNR (show P2RY4 Proteins) expression and eIF-2alpha (show EIF2S1 Proteins) phosphorylation.

  5. CDK11 and CK2 (show CSNK2A1 Proteins) expression are individually essential for breast cancer cell survival, including TNBC.

  6. CDK11(p58) kinase activity appears to be involved in early events in the establishment of the centromere protection machinery.

  7. Data indicate that CDK11p58 is an anti-metastatic gene in ERalpha (show ESR1 Proteins)-positive breast cancer and that the regulation of integrin beta3 by CDK11p58 via the repression of ERalpha (show ESR1 Proteins) signaling may constitute part of a signaling pathway underlying breast cancer invasion.

  8. CHK2 (show CHEK2 Proteins) kinase constitutively phosphorylates CDK11(p110) in a DNA damage-independent manner.

  9. CDK11 is critical for the growth and proliferation of liposarcoma cells.

  10. CDK11 signaling is essential in osteosarcoma cell growth and survival, further elucidating the regulatory mechanisms controlling the expression of CDK11 and ultimately develop a CDK11 inhibitor that may provide therapeutic benefit against osteosarcoma.

Mouse (Murine) Cyclin-Dependent Kinase 11B (CDK11B) interaction partners

  1. suggested that CDK11p58 acted to regulate microglia activation through CDK11p58 and cyclin D3 (show CCND3 Proteins) interaction

  2. These data suggest that cyclin D3 (show CCND3 Proteins)/CDK11p58 signaling is involved in the negative regulation of AR function.

  3. CDK11(p58) is expressed in proliferating germ cells in the early stages of developing testes

  4. Cdc2l1 is a previously unrecognized member of the Hh signal transduction cascade.

Cyclin-Dependent Kinase 11B (CDK11B) Protein Profile

Protein Summary

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported.

Alternative names and synonyms associated with Cyclin-Dependent Kinase 11B (CDK11B)

  • cyclin-dependent kinase 11B (CDK11B)
  • cell division cycle 2-like 1 (PITSLRE proteins) (CDC2L1)
  • cyclin-dependent kinase 11A (CDK11A)
  • cyclin-dependent kinase 11B (Cdk11b)
  • cyclin-dependent kinase 19 (Cdk19)
  • 2700084L06Rik protein
  • AA989746 protein
  • AI845279 protein
  • AW228747 protein
  • Cdc2l1 protein
  • Cdc2l2 protein
  • Cdc2l6 protein
  • Cdc11b protein
  • Cdk11 protein
  • CDK11-p46 protein
  • CDK11-p58 protein
  • CDK11-p110 protein
  • CDK11B protein
  • CLK-1 protein
  • mKIAA1028 protein
  • p58 protein
  • p58CDC2L1 protein
  • p58CLK-1 protein
  • PK58 protein

Protein level used designations for CDK11B

cyclin-dependent kinase 11B , PITSLRE protein kinase beta 1 , cell division cycle 2-like 2 (PITSLRE proteins) , cell division cycle 2-like 1 (PITSLRE proteins) , CDC-related protein kinase p58 , PITSLRE serine/threonine-protein kinase CDC2L1 , PITSLREA , cell division cycle 2-like protein kinase 1 , cell division protein kinase 11B , galactosyltransferase-associated protein kinase p58/GTA , p58 CLK-1 , PITSLRE proteins , cell division cycle 2 homolog-like 1 , cell division cycle 2 homolog-like 2 , cell division cycle 2-like 1 , cell division cycle 2-like 2 , cell division protein kinase 11 , cyclin-dependent kinase 11 , CDC2-related protein kinase 6 , cell division cycle 2-like 6 (CDK8-like) , cell division cycle 2-like protein kinase 6 , cell division protein kinase 19 , cyclin-dependent kinase (CDC2-like) 11

469457 Pan troglodytes
493708 Bos taurus
489591 Canis lupus familiaris
984 Homo sapiens
12537 Mus musculus
252879 Rattus norvegicus
78334 Mus musculus
309804 Rattus norvegicus
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