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CDK11 Products

(Cyclin-Dependent Kinase 11B (CDK11B))
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported. [provided by RefSeq, Jul 2008].

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Featured CDK11 Categories

CDK11 Antibodies

High quality antibodies with extensive validation data.

CDK11 ELISA Kits

Reliable ELISA kits for a wide range of species.

CDK11 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CDK11 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application ELISA, ICC, IF, WB
Validations
  • (3)
Cat. No. ABIN6260708
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, IHC, WB
Validations
  • (3)
Cat. No. ABIN7238792
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, ICC, IF, WB
Validations
  • (2)
Cat. No. ABIN6258011
Quantity 100 μL
Datasheet Datasheet

Recommended CDK11 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN5648163
Quantity 96 tests
Datasheet Datasheet

Recommended CDK11 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3091381
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3133418
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348803
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our CDK11 products

Hu, Mayeda, Trembley, Lahti, Kidd: "CDK11 complexes promote pre-mRNA splicing." in: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 8623-9, (2003) (PubMed).

Chen, Yin, Zhu, Yan, Ji, Chen, Cai, Zhang, Zong, Hu, Yuan, Shen, Gu: "The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis." in: The Journal of biological chemistry, Vol. 278, Issue 22, pp. 20029-36, (2003) (PubMed).

Hadano, Hand, Osuga, Yanagisawa, Otomo, Devon, Miyamoto, Showguchi-Miyata, Okada, Singaraja, Figlewicz, Kwiatkowski, Hosler, Sagie, Skaug, Nasir, Brown, Scherer, Rouleau, Hayden, Ikeda: "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2." in: Nature genetics, Vol. 29, Issue 2, pp. 166-73, (2001) (PubMed).

Cornelis, Bruynooghe, Denecker, Van Huffel, Tinton, Beyaert: "Identification and characterization of a novel cell cycle-regulated internal ribosome entry site." in: Molecular cell, Vol. 5, Issue 4, pp. 597-605, (2000) (PubMed).

Gururajan, Lahti, Grenet, Easton, Gruber, Ambros, Kidd: "Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2." in: Genome research, Vol. 8, Issue 9, pp. 929-39, (1998) (PubMed).

Xiang, Lahti, Grenet, Easton, Kidd: "Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms." in: The Journal of biological chemistry, Vol. 269, Issue 22, pp. 15786-94, (1994) (PubMed).

Eipers, Lahti, Kidd: "Structure and expression of the human p58clk-1 protein kinase chromosomal gene." in: Genomics, Vol. 13, Issue 3, pp. 613-21, (1992) (PubMed).

Lake, de la Cruz, Ferreira, Morel, Simpson: "Evolution of parasitism: kinetoplastid protozoan history reconstructed from mitochondrial rRNA gene sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 6, pp. 2612, (1991) (PubMed).

Bunnell, Heath, Adams, Lahti, Kidd: "Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 19, pp. 7467-71, (1990) (PubMed).

Synonyms and alternative names related to CDK11

cyclin dependent kinase 11B (CDK11B), cyclin-dependent kinase 11B (Cdk11b), cyclin-dependent kinase 11B (LOC489591), cyclin-dependent kinase 11B (CDK11B), cyclin-dependent kinase 11B (cdk11b), cyclin-dependent kinase 11B S homeolog (cdk11b.S), AA989746, CDC2L1, Cdc2l1, cdc2l1, Cdc2l2, CDC2L2, cdc2l2, Cdc11b, CDK11, Cdk11, cdk11, CDK11-p46, cdk11-p46, CDK11-p58, cdk11-p58, CDK11-p110, cdk11-p110, CDK11B, cdk11b, CLK-1, clk-1, im:7142267, p58, p58CDC2L1, p58cdc2l1, p58CLK-1, p58clk-1, PK58, pk58, zgc:101589

Protein level used designations for CDK11

  • CDC-related protein kinase p58
  • PITSLRE serine/threonine-protein kinase CDC2L1
  • PITSLREA
  • cell division cycle 2-like 1 (PITSLRE proteins)
  • cell division cycle 2-like protein kinase 1
  • cell division protein kinase 11B
  • galactosyltransferase-associated protein kinase p58/GTA
  • p58 CLK-1
  • cyclin-dependent kinase 11B
  • PITSLRE proteins
  • cell division cycle 2 homolog-like 1
  • cell division cycle 2 homolog-like 2
  • cell division cycle 2-like 1
  • cell division cycle 2-like 2
  • cell division protein kinase 11
  • cyclin-dependent kinase 11
  • PITSLRE protein kinase beta 1
  • cell division cycle 2-like 2 (PITSLRE proteins)
  • cyclin-dependent kinase 11B S homeolog
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