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Browse our SP1 Proteins (SP1)

Full name:
Sp1 Transcription Factor Proteins (SP1)
On are 9 Sp1 Transcription Factor (SP1) Proteins from 6 different suppliers available. Additionally we are shipping SP1 Antibodies (282) and SP1 Kits (22) and many more products for this protein. A total of 326 SP1 products are currently listed.
1110003E12Rik, AA450830, AI845540, fc18h09, SP1, Sp1-1, wu:fc18h09, zgc:85950
list all proteins Gene Name GeneID UniProt
SP1 6667 P08047
Rat SP1 SP1 24790 Q01714
SP1 20683 O89090

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SP1 Proteins (SP1) by Origin

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More Proteins for SP1 Interaction Partners

Zebrafish Sp1 Transcription Factor (SP1) interaction partners

  1. A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Proteins), sp1 and sod1 (show SOD1 Proteins) in zebrafish.

  2. zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1

Human Sp1 Transcription Factor (SP1) interaction partners

  1. decreased expression of transcription factor Sp1 contributes to suppression of SHIP2 (show INPPL1 Proteins) in gastric cancer cells.

  2. this study shows that IL-10 (show IL10 Proteins) production by CD20 (show MS4A1 Proteins)+ B cells among peripheral blood mononuclear cell is enhanced by bendamustine via p38 MAP kinase (show MAPK14 Proteins)-Sp1 (show PSG1 Proteins) pathway

  3. During inflammatory conditions, AP-1 (show FOSB Proteins) and Sp1 (show PSG1 Proteins) sustained the expression of ADAMTS7 (show ADAMTS7 Proteins), and ADAMTS7 (show ADAMTS7 Proteins) sustained the expression of catabolic genes in nucleus pulposus cells

  4. there is a SP1 (show PSG1 Proteins) site in DKK1 (show DKK1 Proteins) promoter region; overexpression of SP1 (show PSG1 Proteins) could increase DKK1 (show DKK1 Proteins) promoter activity in a dose dependent manner; and siRNA inhibition of SP1 (show PSG1 Proteins) expression reduced DKK1 (show DKK1 Proteins) promoter activity and decreased the expression of DKK1 (show DKK1 Proteins) protein.

  5. The data demonstrated that Sp1 transcription factor protein (show SSRP1 Proteins) expression is induced by TNFalpha (show TNF Proteins) and interleukin1 beta.

  6. It was found that miR411 was significantly downregulated in breast cancer, and associated with lymph node metastasis and histological grade. Additionally, it was observed that miR411 suppressed cell growth, migration and invasion in the breast cancer cells. miRNA-411 acts as a potential tumor suppressor miRNA via the downregulation of specificity protein 1 in breast cancer.

  7. the present study suggests that GAPDH (show GAPDH Proteins) plays an important role in cancer metastasis by affecting EMT (show ITK Proteins) through regulation of Sp1 (show PSG1 Proteins)-mediated SNAIL (show SNAI1 Proteins) expression.

  8. the primary activating regulatory region of human IRF5 (show IRF5 Proteins) was located in its minimal promoter region between nucleotides -179 and +62. In addition, it was shown that Sp1 (show PSG1 Proteins) was able to bind to the multiple sites in IRF5 (show IRF5 Proteins) promoter region, and was involved in the transcriptional regulation of IRF5 (show IRF5 Proteins) at the basal level.

  9. melatonin suppresses the motility of NPC (show NPC1 Proteins) by regulating TPA (show PLAT Proteins)-induced MMP-9 (show MMP9 Proteins) gene expression via inhibiting SP-1 (show PSG1 Proteins)-DNA binding ability. The results provide a functional link between melatonin-mediated SP-1 (show PSG1 Proteins) regulation and the antimetastatic actions of melatonin on nasopharyngeal carcinoma.

  10. miRNA-223 specifically regulates the epithelial-mesenchymal transition (EMT (show ITK Proteins))process of gastric cancer cells through its target gene Sp1 (show PSG1 Proteins). Overexpression of miRNA-223 in these cells inhibits EMT (show ITK Proteins) via the miRNA-223/Sp1 (show PSG1 Proteins)/EMT (show ITK Proteins) pathway

Cow (Bovine) Sp1 Transcription Factor (SP1) interaction partners

  1. study demonstrates the co-expression of DLX3 (show DLX3 Proteins), PPARG (show PPARG Proteins) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation

  2. likely involvement of the Sp family in regulating PTH (show PTH Proteins) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.

  3. These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.

  4. The coordinate regulation of the bovine PRNP (show PRNP Proteins) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP Proteins) promoter and its activity.

Mouse (Murine) Sp1 Transcription Factor (SP1) interaction partners

  1. SP1 expression was up-regulated in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion.MiR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells.

  2. miR (show MLXIP Proteins)-124, -128, and -137 act synergistically to regulate Sp1 expression.

  3. YY1 (show YY1 Proteins) and SP1 independently and cooperatively govern the Mesp1 (show MESP1 Proteins) expression during embryogenesis.

  4. Taken together, these results indicate that the transcription factor Sp1 upregulates the proximal promoter activity of the mouse Col11a1 gene in chondrocytes.

  5. In the initial stage of myocyte differentiation, transcription of the YB-1 (show YBX1 Proteins) gene was regulated by E2F1 (show E2F1 Proteins) and Sp1, and was then gradually replaced under the control of both MyoD (show MYOD1 Proteins) and myogenin (show MYOG Proteins).

  6. Data indicate that Sp1 and AP-1 (show JUN Proteins)-related factors are involved in the regulation of MFG-E8 (show MFGE8 Proteins) gene transcription by targeting their binding sites in the 5'-flanking region under physiological and inflammatory states.

  7. Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.

  8. age-dependent alteration in the Fmr-1 (show FMR1 Proteins) gene expression is associated with Sp1 interaction with Fmr-1 (show FMR1 Proteins) promoter which in turn might be related with cognitive development during brain maturation and aging.

  9. The results of this study suggest that SP4 and SP1 upregulation may be part of the mechanisms deregulated downstream of glutamate (show GRIN1 Proteins) signalling pathways in schizophrenia

  10. The transcription factor SP1 is induced in brain by ischemia/reperfusion.

SP1 Protein Profile

Protein Summary

The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SP1

  • sp1 transcription factor (sp1)
  • Sp1 transcription factor (sp1)
  • Sp1 transcription factor (SP1)
  • Sp1 transcription factor (LOC100351317)
  • Sp1 transcription factor (Sp1)
  • trans-acting transcription factor 1 (Sp1)
  • 1110003E12Rik protein
  • AA450830 protein
  • AI845540 protein
  • fc18h09 protein
  • SP1 protein
  • Sp1-1 protein
  • wu:fc18h09 protein
  • zgc:85950 protein

Protein level used designations for Sp1 Transcription Factor Proteins (SP1)

Sp1-like protein , transcription factor Sp1 , transcription factor , Sp1 transcription factor , transcription factor Sp1-like , specificity protein 1 , specific protein-1 , trans-acting transcription factor 1

324109 Danio rerio
394744 Xenopus (Silurana) tropicalis
451939 Pan troglodytes
702710 Macaca mulatta
100351317 Oryctolagus cuniculus
100407824 Callithrix jacchus
100440745 Pongo abelii
100474983 Ailuropoda melanoleuca
100553756 Anolis carolinensis
100585963 Nomascus leucogenys
6667 Homo sapiens
540741 Bos taurus
24790 Rattus norvegicus
397314 Sus scrofa
431939 Xenopus laevis
395303 Gallus gallus
486507 Canis lupus familiaris
100303456 Ovis aries
20683 Mus musculus
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