Browse our SP1 Proteins (SP1)

Full name:
Sp1 Transcription Factor Proteins (SP1)
On are 9 Sp1 Transcription Factor (SP1) Proteins from 6 different suppliers available. Additionally we are shipping SP1 Antibodies (286) and SP1 Kits (25) and many more products for this protein. A total of 334 SP1 products are currently listed.
1110003E12Rik, AA450830, AI845540, fc18h09, SP1, Sp1-1, wu:fc18h09, zgc:85950
list all proteins Gene Name GeneID UniProt
SP1 6667 P08047
Rat SP1 SP1 24790 Q01714
SP1 20683 O89090

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SP1 Proteins (SP1) by Origin

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More Proteins for SP1 Interaction Partners

Zebrafish Sp1 Transcription Factor (SP1) interaction partners

  1. A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Proteins), sp1 and sod1 (show SOD1 Proteins) in zebrafish.

  2. zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1

Human Sp1 Transcription Factor (SP1) interaction partners

  1. Data indicate that DNMT3A (show DNMT3A Proteins) allele G of rs1550117 was associated with an increased risk of non-small cell lung cancer (NSCLC) susceptibility and binding affinity of transcription repressor SP1 (show PSG1 Proteins).

  2. Sp1 (show PSG1 Proteins)-DNA binding affinity is reduced under Cu replete conditions but increased under reduced Cu conditions.

  3. Triptolide downregulates Sp1 (show PSG1 Proteins) and HSP70 (show HSP70 Proteins) mRNA in gastric cancer cell lines.

  4. Data indicate that interleukin 1alpha (IL-1alpha) propiece can activate NF-kappa B (NFkappaB (show NFKB1 Proteins)) and Sp1 transcription factor (SP1).

  5. miR (show MLXIP Proteins)-31-5p acted as a tumor suppressor to regulate SP1 (show PSG1 Proteins), miR (show MLXIP Proteins)-31-5p could be used as a therapeutic target for the treatment ofhepatocellular carcinoma.

  6. the overexpression of miR (show MLXIP Proteins)-141 augments anoikis resistance in ovarian cancer cells by targeting and repressing the expression of KLF12 (show KLF12 Proteins), which, in turn, competes for binding sites in the survivin (show BIRC5 Proteins) promoter with Sp1 (show PSG1 Proteins). The subsequent increase in survivin (show BIRC5 Proteins) then protects ovarian cancer cells against anoikis by blocking the intrinsic apoptotic activity.

  7. this study uncovered the mechanism through which mithramycin inhibits epithelial-to-mesenchymal transition and invasion in salivary adenoid cystic carcinoma cell lines, namely, via downregulating specificity protein 1 and SNAI1 (show SNAI1 Proteins) expression, which suggests mithramycin may be a promising therapeutic option for salivary adenoid cystic carcinoma.

  8. the two Q-domains of Sp1 (show PSG1 Proteins) and four Q-domains of TAF4 (show TAF4 Proteins) were disordered under physiological conditions.

  9. Taken together, these findings collectively demonstrate that microRNA-337 exerts its tumor-suppressing roles in cervical cancer by directly targeting specificity protein 1, thereby indicating a potential novel potential therapeutic target for patients with cervical cancer.

  10. findings support the idea that RYBP (show RYBP Proteins) may represent a target for cancer therapy and suggest that it may be useful as a prognostic biomarker for HCC (show FAM126A Proteins), either alone or in combination with KLF4 (show KLF4 Proteins) and Sp1 (show PSG1 Proteins)

Cow (Bovine) Sp1 Transcription Factor (SP1) interaction partners

  1. study demonstrates the co-expression of DLX3 (show DLX3 Proteins), PPARG (show PPARG Proteins) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation

  2. likely involvement of the Sp family in regulating PTH (show PTH Proteins) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.

  3. These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.

  4. The coordinate regulation of the bovine PRNP (show PRNP Proteins) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP Proteins) promoter and its activity.

Mouse (Murine) Sp1 Transcription Factor (SP1) interaction partners

  1. Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 (show NFATC1 Proteins) and Sp1, reducing the level of free Sp1 to inhibit microRNA miR (show MLXIP Proteins)-139-5p expression and promote osteoclastogenesis.

  2. data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1/SIRT1 (show SIRT1 Proteins) signaling pathway.

  3. This resulted in Sp1 displacement from the promoter and binding of Sp3 to it, leading to p300 recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3-mediated gene regulation that may apply to other genes

  4. adrenergic stimulation induced complex formation between Ifrd1 (show IFRD1 Proteins), Sp1 and mSIN3B, which is a component of the SIN (show POLR3E Proteins) complex containing histone deacetylase (show HDAC1 Proteins), in brown adipocytes. These findings, therefore, suggest that Ifrd1 (show IFRD1 Proteins) could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.

  5. Dp71 (show DMD Proteins) expression in hepatic cells is carried out, in part, by YY1 (show YY1 Proteins)-, Sp1- and Sp3-mediated transcription from the Dp71 (show DMD Proteins) promoter.

  6. SP1 expression was up-regulated in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion.MiR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells.

  7. miR (show MLXIP Proteins)-124, -128, and -137 act synergistically to regulate Sp1 expression.

  8. YY1 (show YY1 Proteins) and SP1 independently and cooperatively govern the Mesp1 (show MESP1 Proteins) expression during embryogenesis.

  9. Taken together, these results indicate that the transcription factor Sp1 upregulates the proximal promoter activity of the mouse Col11a1 gene in chondrocytes.

  10. In the initial stage of myocyte differentiation, transcription of the YB-1 (show YBX1 Proteins) gene was regulated by E2F1 (show E2F1 Proteins) and Sp1, and was then gradually replaced under the control of both MyoD (show MYOD1 Proteins) and myogenin (show MYOG Proteins).

SP1 Protein Profile

Protein Summary

The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SP1

  • sp1 transcription factor (sp1)
  • Sp1 transcription factor (sp1)
  • Sp1 transcription factor (SP1)
  • Sp1 transcription factor (LOC100351317)
  • Sp1 transcription factor (Sp1)
  • trans-acting transcription factor 1 (Sp1)
  • 1110003E12Rik protein
  • AA450830 protein
  • AI845540 protein
  • fc18h09 protein
  • SP1 protein
  • Sp1-1 protein
  • wu:fc18h09 protein
  • zgc:85950 protein

Protein level used designations for Sp1 Transcription Factor Proteins (SP1)

Sp1-like protein , transcription factor Sp1 , transcription factor , Sp1 transcription factor , transcription factor Sp1-like , specificity protein 1 , specific protein-1 , trans-acting transcription factor 1

324109 Danio rerio
394744 Xenopus (Silurana) tropicalis
451939 Pan troglodytes
702710 Macaca mulatta
100351317 Oryctolagus cuniculus
100407824 Callithrix jacchus
100440745 Pongo abelii
100474983 Ailuropoda melanoleuca
100553756 Anolis carolinensis
100585963 Nomascus leucogenys
6667 Homo sapiens
540741 Bos taurus
24790 Rattus norvegicus
397314 Sus scrofa
431939 Xenopus laevis
395303 Gallus gallus
486507 Canis lupus familiaris
100303456 Ovis aries
20683 Mus musculus
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