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A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Proteins), sp1 and sod1 (show SOD1 Proteins) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
High SP1 (show PSG1 Proteins) expression is associated with obesity.
The up-regulation of Hsp27 (show HSPB1 Proteins) by E2 is mediated by ERalpha (show ESR1 Proteins)/Sp1 (show PSG1 Proteins).
Identification of heteromolecular binding sites in transcription factors Sp1 (show PSG1 Proteins) and TAF4 (show TAF4 Proteins) using high-resolution nuclear magnetic resonance spectroscopy has been reported.
Stimulation of ribosomal RNA gene promoter by transcription factor Sp1 involves active DNA demethylation by Gadd45 (show GADD45A Proteins)-NER (show NR1H2 Proteins) pathway.
TIP60 (show KAT5 Proteins)-mediated growth suppression of HPV-induced cervical cancer is mediated in part due to TERT (show TERT Proteins) repression through Sp1 (show PSG1 Proteins) acetylation. In summary, our study has identified a novel substrate for TIP60 (show KAT5 Proteins) catalytic activity and a unique repressive mechanism acting at the TERT (show TERT Proteins) promoter in virus-induced malignancies.
AGEs treatment increased the expression of RAGE (show AGER Proteins), Sp1 (show PSG1 Proteins), and MMP2 (show MMP2 Proteins) in a dose-dependent manner.
E6 upregulation of hTERT by downregulated LKB1 (show STK11 Proteins) and upregulated SP1 (show PSG1 Proteins) in lung cancer cells. These results indicated that E6 played a predominant role in the regulation of telomerase activation and may be a valuable therapeutic targets for HPV-related cancer.
Results have shown crosstalk among the EGFR (show EGFR Proteins) cascade and Sp1 (show PSG1 Proteins) and DPD (show DPYD Proteins) expressions in EGFR (show EGFR Proteins) mutant non-small-cell lung cancer cell lines. EGF (show EGF Proteins)-induced Sp1 (show PSG1 Proteins) up-regulation resulted in both DPYD (show DPYD Proteins) mRNA and DPD (show DPYD Proteins) protein expressions.
AKT (show AKT1 Proteins)/GSK-3beta-mediated stabilization of SP1 (show PSG1 Proteins) is required for TGF-beta (show TGFB1 Proteins) induced up-regulation of NKG2DLs.
miR-612 has a suppressive role on hepatocellular carcinoma cell stemness via Sp1/Nanog signaling pathway.
study demonstrates the co-expression of DLX3 (show DLX3 Proteins), PPARG (show PPARG Proteins) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (show PTH Proteins) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (show PRNP Proteins) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP Proteins) promoter and its activity.
Using MA, we demonstrated Sp1 as a critical stemness-related transcriptional factor protecting GBM cells against stress- and TMZ-induced death. Thus, Sp1 inhibition may prevent recurrence of malignant cells persisting after primary therapy.
Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 (show NFATC1 Proteins) and Sp1, reducing the level of free Sp1 to inhibit microRNA miR (show MLXIP Proteins)-139-5p expression and promote osteoclastogenesis.
data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1/SIRT1 (show SIRT1 Proteins) signaling pathway.
This resulted in Sp1 displacement from the promoter and binding of Sp3 to it, leading to p300 recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3-mediated gene regulation that may apply to other genes
adrenergic stimulation induced complex formation between Ifrd1 (show IFRD1 Proteins), Sp1 and mSIN3B, which is a component of the SIN (show POLR3E Proteins) complex containing histone deacetylase (show HDAC1 Proteins), in brown adipocytes. These findings, therefore, suggest that Ifrd1 (show IFRD1 Proteins) could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.
Dp71 (show DMD Proteins) expression in hepatic cells is carried out, in part, by YY1 (show YY1 Proteins)-, Sp1- and Sp3-mediated transcription from the Dp71 (show DMD Proteins) promoter.
SP1 expression was up-regulated in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion.MiR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells.
miR (show MLXIP Proteins)-124, -128, and -137 act synergistically to regulate Sp1 expression.
YY1 (show YY1 Proteins) and SP1 independently and cooperatively govern the Mesp1 (show MESP1 Proteins) expression during embryogenesis.
Taken together, these results indicate that the transcription factor Sp1 upregulates the proximal promoter activity of the mouse Col11a1 gene in chondrocytes.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1