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Integrating population variation and protein structural analysis is harnessed to improve clinical interpretation of missense mutations in WD40 domain (show DCAF12L2 Proteins)-containing TBLR1 protein for the prognosis of developmental disabilities.
in splenic hemangioma with t(3;6)(q26;p21 (show CDKN1A Proteins)), the entire coding region of HMGA1 (show HMGA1 Proteins) comes under the control of the TBL1XR1 promoter, bringing about dysregulation of HMGA1 (show HMGA1 Proteins)
These finding suggested that TBLR1 is likely to be a potential prognostic indicator and therapeutic target for HCC (show FAM126A Proteins) and that TBLR1 may be implicated in EMT (show ITK Proteins) of HCC (show FAM126A Proteins) cells.
Results show that upregulation of TBL1XR1 induces Nasopharyngeal Carcinoma cells resistance to cisplatin by activating the NF-kappaB (show NFKB1 Proteins) pathway.
that TBL1XR1 haploinsufficiency can cause intellectual disability with a recognizable dysmorphism, without necessarily causing autistic behavior.
TBLR1 plays a key role in the development and progression of breast cancer cells via cyclin D1 (show CCND1 Proteins)-transactivation and activation of the beta-catenin (show CTNNB1 Proteins) signaling pathway.
Patient with TBL1XR1 mutation [c.209 G>A (p.Gly70Asp)] leading to West syndrome with Rett-like features, together with autistic features was reported.
results demonstrated that TBL1XR1 induced lymphangiogenesis and lymphatic metastasis in esophageal squamous cell carcinoma via upregulation of VEGF-C (show VEGFC Proteins), and may represent a novel prognostic biomarker and therapeutic target for patients with ESCC.
data indicate that loss of TBL1XR1 is a novel driver of glucocorticoid resistance in ALL and that epigenetic therapy may have future application in restoring drug sensitivity at relapse.
The TBLR1 protein may be a prognostic marker in cervical cancer and play an important role in the invasion and metastasis of human cervical cancer
The cell autonomous transcriptional activity of TBLR1 controls multiple beta-adrenoceptor and postreceptor checkpoints in white adipocytes, thereby coordinating an integrated response of cAMP-dependent free fatty acid (FFA) mobilization.
TBLR1 and TBL1 (show TBL1X Proteins) have roles in specific nuclear receptor-mediated gene activation events
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation.
transducin (beta)-like 1 X-linked receptor 1
, F-box-like/WD repeat-containing protein TBL1XR1
, f-box-like/WD repeat-containing protein TBL1XR1-like
, transducin (beta)-like 1X-linked receptor 1
, nuclear receptor co-repressor/HDAC3 complex subunit
, TBL1-related protein 1
, nuclear receptor corepressor/HDAC3 complex subunit TBLR1
, transducin beta-like 1X-related protein 1
, F-box-like/WD repeat protein TBL1XR1