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this paper shows that endosomal retention of TLR9 (show TLR9 Proteins) via the interaction of IRAP (show IL1RN Proteins) with the actin cytoskeleton is a mechanism that prevents hyper-activation of TLR9 (show TLR9 Proteins) in dendritic cells
IRAP (show IL1RN Proteins) is more highly expressed in pro-inflammatory M1-activated macrophages.
IRAP (show IL1RN Proteins) deficiency may lead to suppression of PAI-1 (show SERPINE1 Proteins) expression in adipocytes and upregulation of UCP-1 (show UCP1 Proteins)-mediated thermogenesis in brown adipose tissue and increased energy expenditure to prevent the development of obesity.
The current study demonstrates that deletion of the IRAP (show IL1RN Proteins) gene protects the brain from ischemic damage
IRAP (show IL1RN Proteins)-deficient mice are less sensitive to the development of acute pentylenetetrazol-induced seizures, demonstrating that IRAP (show IL1RN Proteins) may be involved in generalized seizure generation.
requirement of IRAP (show IL1RN Proteins) in cross-presentation extends to steady-state conventional dendritic cells (cDCs);data suggest increased recruitment of an IRAP (show IL1RN Proteins)(+)/Rab14 (show RAB14 Proteins)(+) compartment to Ag-containing vesicles contributes to cross-presentation efficacy of CD8 (show CD8A Proteins)(+)cDCs
These findings suggest that the IRAP (show IL1RN Proteins) binding protein, vimentin (show VIM Proteins), plays an important role in retention of GLUT4 (show SLC2A4 Proteins) storage vesicles.
IRAP (show IL1RN Proteins) functions in GLUT4 (show SLC2A4 Proteins) sorting from endosomes to GLUT4 (show SLC2A4 Proteins)-specialized compartments.
study shows the high-affinity binding site for angiotensin IV is absent in IRAP (show IL1RN Proteins) knockout mice brain sections in parallel with loss of IRAP (show IL1RN Proteins) immunostaining, providing irrefutable proof that IRAP (show IL1RN Proteins) is the specific high-affinity binding site for AT(4) ligands
Data suggest that the physiological significance of circulating insulin-regulated aminopeptidase during human pregnancy cannot be addressed by investigations on mice.
Vasopressinase might be a potential early biomarker for acute kidney injury after cardiopulmonary bypass.
Structural and biological characterization of three low molecular weight aryl sulfonamides: binding modes to human IRAP (show IL1RN Proteins) were explored by docking calculations combined with molecular dynamics simulations and binding affinity estimations using the linear interaction energy method. Two of these drug-like IRAP (show IL1RN Proteins) inhibitors can alter dendritic spine morphology and increase spine density in primary cultures of hippocampal neurons
The PCR-RFLP is a simple and reliable method that allows a quick genotyping for the rs4869317 SNP of LNPEP gene.
This study describes a crystal structure of insulin-regulated aminopeptidase in complex with a recently developed bioactive and selective inhibitor at 2.53 A resolution.
The substrate Angiotensin II, the enzymes aminopeptidases-A, B, M as well as IRAP (show IL1RN Proteins) were detected in the jejunal mucosa.
Determined is the crystal structure of human IRAP (show IL1RN Proteins) revealing a closed, four domain arrangement with a large, mostly buried cavity abutting the active site.
We identified the missense variant rs2303138 (p.Ala763Thr) within the LNPEP gene associated with psoriasis.
Activities of aminopeptidases N and B and insulin-regulated aminopeptidase could be useful non-invasive biomarkers of Alzheimer's disease from the earliest stages.
An association between maternal common polymorphisms in LNPEP and susceptibility to preterm birth was observed.
The genetic variation in LNPEP (vasopressinase) is associated with 28-day mortality in septic shock and is associated with biologic effects on vasopressin (show AVP Proteins) clearance and serum sodium regulation
This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.
, leucyl-cystinyl aminopeptidase-like
, leucyl-cystinyl aminopeptidase
, cystinyl aminopeptidase
, aminopeptidase Vp165
, angiotensin IV receptor
, insulin-regulated membrane aminopeptidase IRAP
, insulin-responsive aminopeptidase
, placental leucine aminopeptidase
, vesicle protein of 165 kDa
, AT (4) receptor
, insulin-regulated aminopeptidase
, insulin-regulated membrane aminopeptidase
, AT4 receptor