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cullin-5 and cullin-2 (show CUL2 ELISA Kits) play a role in the development of neuromuscular junction and the female germ line of Drosophila
Data show that the follicular epithelium that normally encapsulates single germ line cysts develops aberrantly in cul-5 mutant.
cul-5 plays multiple roles in cell fate specification and synapse formation during Drosophila development.
these findings identify Cul-5 as a signaling component that connects an LPS (show IRF6 ELISA Kits)-activated TLR4 (show TLR4 ELISA Kits)-MyD88 (show MYD88 ELISA Kits) complex to TRAF6 (show TRAF6 ELISA Kits) for efficient activation of NF-kappaB (show NFKB1 ELISA Kits)
CUL5 neddylation may allosterically tune polyubiquitin (show UBB ELISA Kits) chain length and topology.
Study found that CUL5 expression was significantly decreased in both endometrioid adenocarcinomas with the more aggressive serous type displaying a higher reduction. Its mRNA and protein overexpression in endometrial cancer cells resulted in decreased cell proliferation.
Studies indicate that Cullin-RING E3 ubiquitin ligases (CRL) are key players of the ubiquitylation pathway.
These results provide important information on the assembly of the Vif (show BTG1 ELISA Kits)-CUL5-E3 ubiquitin ligase and identify a new viV binding interface with CBF-beta (show CBFB ELISA Kits) at the C-terminus of HIV-1 Vif (show BTG1 ELISA Kits).
Data indicate that cell surface adhesion molecules VCAM-1 (show VCAM1 ELISA Kits) and P-selectin (show SELP ELISA Kits) play some roles in mechanical stretch-induced HL-60 cell adhesion to mouse common carotid arteries.
N-terminal mutants of HIV-1 vif that demonstrated reduced Cul5 binding were also unable to degrade APOBEC3G as well as APOBEC3F.
A tumor suppressor gene, CUL5, is identified as a direct target of miR-7 (show LILRB1 ELISA Kits) in hepatocellular carcinoma.
Silencing CUL5 reduced cellular sensitivity to three distinct HSP90 (show HSP90 ELISA Kits) inhibitors, across four cancer types driven by different protein kinases.
In the absence of CBFbeta (show CBFB ELISA Kits), Vif (show BTG1 ELISA Kits) does not bind Cul5, thus preventing the assembly of the E3 ligase complex.
neural precursor cell expressed developmentally downregulated (show NEDD8 ELISA Kits) protein 8 (Nedd8 (show NEDD8 ELISA Kits)) modification of Cul-5 is required for its interaction with TRAF6 (show TRAF6 ELISA Kits).
Our results show that endogenous Cul5 suppresses epithelial cell transformation by several pathways, including inhibition of Src (show SRC ELISA Kits)-Cas (show CTNND1 ELISA Kits)-induced ruffling through SOCS6 (show SOCS6 ELISA Kits)
The expression of cullin5 on retinal cells and reduction in the percentage of dead retinal cells induced by L-glutamate (show GRIN1 ELISA Kits) suggest that cullin5 has neuroprotective properties in retinal cells.
SOCS (show CISH ELISA Kits) box acts as an independent binding domain capable of recruiting elonginBC and cullin5 to promote E3 ligase formation.
The role of Cul5 is to degrade disabled homolog 1 (Dab1 (show DAB1 ELISA Kits)) and thus control neuron migration speed and neuron insertion at the top of the cortical plate.
These results suggest that, when Src (show SRC ELISA Kits) is activated by mutation or physiological mechanisms, its effects are limited by Culllin 5, which downregulates active Src (show SRC ELISA Kits) and its phosphorylated substrates.
data imply the existence of two distinct subclasses of SOCS (show CISH ELISA Kits) proteins with a high affinity for Cullin5, the E3 ligase scaffold, possibly reflecting complete dependence upon ubiquitination for suppression of cytokine signalling
The study results suggest that VACM-1 may regulate endothelial AQP1 concentration both in vivo and in vitro.
oocyte maturation from pachytene exit and MPK-1 (show MAPK1 ELISA Kits) activation are redundantly controlled by the RBX-2-CUL-5- and RBX-1 (show RBX1 ELISA Kits)-CUL-2 (show CUL2 ELISA Kits)-based complexes.
neuropeptide arginine vasopressin receptor\; may have a role in the central nervous system
Vasopressin-activated calcium-mobilizing receptor (VACM-1)
, cullin 5
, Vasopressin-activated calcium-mobilizing receptor-1
, Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1)
, vasopressin-activated calcium-mobilizing receptor 1
, vasopressin-activated calcium-mobilizing receptor protein
, vasopressin-activated calcium-mobilizing protein