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Browse our DMPK Proteins (DMPK)

Full name:
Dystrophia Myotonica-Protein Kinase Proteins (DMPK)
On are 10 Dystrophia Myotonica-Protein Kinase (DMPK) Proteins from 5 different suppliers available. Additionally we are shipping DMPK Antibodies (79) and DMPK Kits (4) and many more products for this protein. A total of 100 DMPK products are currently listed.
list all proteins Gene Name GeneID UniProt
DMPK 1760 Q09013
DMPK 13400 P54265
DMPK 308405  

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Human Dystrophia Myotonica-Protein Kinase (DMPK) interaction partners

  1. Study shows DMPK expression with a complex pattern of tissue-specific epigenetics consistent with evidence that normal tissue require careful regulation of its RNA and protein levels which might include cis (show CISH Proteins)-acting regulatory elements in neighboring genes.

  2. Sense DMPK RNA foci clearly co-localize with MBNL1 (show MBNL1 Proteins) and MBNL2 (show MBNL2 Proteins) proteins and accumulate in myotonic dystrophy 1 tissues during development.

  3. miR (show MLXIP Proteins)-206 and miR (show MLXIP Proteins)-148a regulate the DMPK transcript and may functionally cooperate.

  4. In conclusion, our data suggest that the frequency of DMPK mutation carriers and the prevalence of DM1 in the Korean population might be higher than those reported in other ethnicities. Supporting

  5. The results show that a DEAD-box helicase, DDX6 (show DDX6 Proteins), interacts with CUG-expanded DMPK-mRNA in primary fibroblasts from dystrophia myotonica type 1 patients.

  6. The mismatch repair components MSH2 (show MSH2 Proteins), MSH3 and MSH6 (show MSH6 Proteins) were highly expressed in iPSCs compared with fibroblasts, and only occupied the DMPK1 gene harboring longer CTG.CAG triplet repeats

  7. This work may shed light on the alteration of this class of non-coding RNA as an additional molecular mechanisms involved in DM1 pathophysiology.

  8. Together with HK II (show HK2 Proteins) and Src (show SRC Proteins), mitochondrial DMPK is part of a multimolecular complex endowed with antioxidant and pro-survival properties.

  9. DMPK alleles in the samples cover four of five DM1 clinical categories: normal (5 to 34 repeats), mild (50 to 100 repeats), classical (101 to 1000 repeats), and congenital (>1000 repeats

  10. The results of this study supported the conclusion that different patterns of CCG interruptions within the CTG array could modulate the DM1 clinical phenotype, variably affecting the mutational dynamics of the variant repeat.

Mouse (Murine) Dystrophia Myotonica-Protein Kinase (DMPK) interaction partners

  1. Sense DMPK RNA foci clearly co-localize with MBNL1 (show MBNL1 Proteins) and MBNL2 (show MBNL2 Proteins) proteins and accumulate in myotonic dystrophy 1 tissues during development.

  2. The data of this study demonstrated that DMPK knockout mice present altered beta-agonist-induced responses and suggest that this is due, at least in part, to a reduced density of beta(1)-adrenergic receptors in cardiac plasma membranes.

  3. Cytosolic DMPK participates in remodeling of the actomyosin cytoskeleton in developing skeletal muscle cells.

  4. Muscleblind1, but not Dmpk or Six5, contributes to a complex phenotype of muscular and motivational deficits in mouse models of myotonic dystrophy

  5. a tail-anchored myotonic dystrophy protein kinase isoform induces perinuclear clustering of mitochondria, autophagy, and apoptosis

  6. Dmpk deficiency results in a sodium (Na) channel abnormality comprising frequent, long bursts of Na channel reopenings during sustained depolarization resulting in a plateau of non-inactivating late Na current.

  7. DMPK has a modulatory role in the control of intracellular Ca2 (show CA2 Proteins)+ concentration in mouse ventricular cardiomyocytes, loss of which contributes to cardiac dysfunction in myotonic dystrophy.

  8. role for DMPK in synaptic plasticity that could be relevant to the cognitive dysfunction associated with myotonic dystrophy

  9. DMPK isoforms have cell-type and location dependent substrate specificities with a role in organellar and cytoarchitectural dynamics

  10. Dmpk mRNA is expressed in a range of adult mouse tissues that including skeletal muscle, heart, smooth muscle, bone, testis, pituitary, brain, eye, skin, thymus,lung,intestinal epithelium, cartilage and liver.

DMPK Protein Profile

Protein Summary

The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Alternative names and synonyms associated with DMPK

  • dystrophia myotonica-protein kinase (DMPK)
  • dystrophia myotonica-protein kinase (Dmpk)
  • DM protein
  • DM1 protein
  • DM1PK protein
  • Dm15 protein
  • DMK protein
  • DMPK protein
  • MDPK protein
  • MT-PK protein

Protein level used designations for DMPK

dystrophia myotonica-protein kinase , myotonic dystrophy protein kinase , myotonin-protein kinase-like , DM protein kinase , DM-kinase , DM1 protein kinase , myotonic dystrophy associated protein kinase , myotonin protein kinase A , myotonin-protein kinase , thymopoietin homolog , dystrophia myotonica kinase, B15

456139 Pan troglodytes
715328 Macaca mulatta
100434494 Pongo abelii
100617691 Monodelphis domestica
1760 Homo sapiens
13400 Mus musculus
308405 Rattus norvegicus
484436 Canis lupus familiaris
513675 Bos taurus
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