DMPK Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
Quick Overview for DMPK Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag) (ABIN2719534)
Target
See all DMPK ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- Transcript Variant 2
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Purification tag / Conjugate
- This DMPK protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human DMPK (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Dystrophia Myotonica-Protein Kinase (DMPK) (AA 1-631) protein (His tag)
custom-made DMPK Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Dystrophia Myotonica-Protein Kinase (DMPK) (AA 1-629) protein (His tag)custom-made DMPK Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Dystrophia Myotonica-Protein Kinase (DMPK) (AA 1-629) protein (GST tag)DMPK Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Dystrophia Myotonica-Protein Kinase (DMPK) (Transcript Variant 4) protein (Myc-DYKDDDDK Tag)DMPK Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- DMPK (Dystrophia Myotonica-Protein Kinase (DMPK))
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Alternative Name
- Dmpk
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Background
- The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3&apos untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
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Molecular Weight
- 69.2 kDa
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NCBI Accession
- NP_004400
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Pathways
- Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development
Target
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