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Fragile X Mental Retardation 1 ELISA Kits (FMR1)
On are 5 Fragile X Mental Retardation 1 (FMR1) ELISA Kits from 4 different suppliers available. Additionally we are shipping FMR1 Antibodies (171) and FMR1 Proteins (7) and many more products for this protein. A total of 190 FMR1 products are currently listed.
AT24755, BcDNA:GM08679, cg6203, dfmr, dfmr1, dFmrp, dfxr, dfxr1, dFXRP, Dmel\\CG6203, dmfr1, EP(3)3517, fmr, Fmr-1, fmr1, Fmrp, FRAXA, FXR, POF, POF1, zFMR1
list all ELISA KIts Gene Name GeneID UniProt
FMR1 2332 Q06787
Rat FMR1 FMR1 24948 Q80WE1
Mouse FMR1 FMR1 14265  

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Fruit Fly (Drosophila melanogaster) Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. Fmr1 protein associates with ninaE (show RHO ELISA Kits) mRNA and represses its translation.

  2. Our data strongly support a gain-of-function pathogenic mechanism of PQBP1 (show PQBP1 ELISA Kits) c.459_462delAGAG and c.463_464dupAG mutations, and suggest that therapeutic strategies to restore FMRP function may be beneficial for those patients

  3. dFMRP cooperates with Piwi in maintaining genome integrity by silencing heterochromatic genes and suppressing transposon expression.

  4. results show Fragile X Mental Retardation Protein (FMRP) shapes neuron class-specific calcium signaling in excitatory vs. inhibitory neurons in developing learning/memory circuitry, and that FMRP mediates activity-dependent regulation of calcium signaling specifically during the early-use critical period.

  5. results support a model whereby dFMRP can modulate the neurotoxicity caused by TDP-43 (show TARDBP ELISA Kits) overexpression

  6. demonstrate that Zfrp8 genetically interacts with Fmr1 and tral (show LSM14A ELISA Kits) in an antagonistic manner. Zfrp8 and FMRP both control heterochromatin packaging, also in opposite ways

  7. dFmr1 protein is essential for proper cardiac function and establish the fly as a new model for studying the role(s) of FraX proteins in the heart.

  8. These results show that dfmr1 acts in a neuron type-specific activity-dependent manner for sculpting dendritic arbors during early-use, critical period development of learning and memory circuitry in the Drosophila brain.

  9. upon the stimulation of replication stress, dFMR1 is associated with chromatin in a domain-specific manner, which is essential for its ability to induce the phosphorylation of H2Av (show H2AFV ELISA Kits).

  10. FMRP inhibits translation by binding directly to the L5 protein on the 80S ribosome.

Human Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. Data show that EZH2 (show EZH2 ELISA Kits) plays a critical role in the FMR1 gene silencing process and that its inhibition can prolong expression of the FMR1 gene even in the presence of its transcript.

  2. Intragenic FMR1 variants, although much less frequent than CGG expansions, are a significant mutational mechanism leading to FXS.

  3. FMR1 triple CGG repeats in the normal range may be associated with primary ovarian insufficiency in China

  4. Expression of FMRpolyG is pathogenic, while the sole expression of CGG RNA is not. FMRpolyG interacts with the nuclear lamina protein LAP2beta (show TMPO ELISA Kits) and disorganizes the nuclear lamina architecture in neurons differentiated from FXTAS iPS (show SLC27A4 ELISA Kits) cells. Finally, expression of LAP2beta (show TMPO ELISA Kits) rescues neuronal death induced by FMRpolyG.

  5. FMR1 CGG trinucleotide repeats were low in Caucasian women with diminished ovarian reserve.

  6. For routine screening of patients/carriers with full/pre-mutations of the FMR1 gene in the population.

  7. Data show that the FMRP deficiency in fragile X syndrome (FXS) patients has significant impact on the gene expression patterns during development, which will help to discover potential targeting candidates for the cure of FXS symptoms.

  8. FMRP plays a role regulating mRNAs during pivotal maturational processes in fetal germ cells, and ovarian dysfunction resulting from FMR1 premutation may have its origins during these stages of oocyte development.

  9. Social anxiety is more frequent in females with the fragile X mental retardation 1 protein (FMR1) premutation than in controls, but not in males.

  10. Study provides evidence linking white matter microstructure to executive dysfunction and elevated FMR1 mRNA and FMR1 exon 1/intron 1 boundary methylation in women with a FMR1 premutation expansion without fragile X-associated tremor/ataxia (show USP14 ELISA Kits) syndrome

Zebrafish Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. We identified thousands of clustered RNA editing sites in the zebrafish transcriptome and showed that Fmrp biochemically interacts with the Adar2a protein. The expression levels of the adar (show ADAR ELISA Kits) genes and Adar2 (show ADARB1 ELISA Kits) protein increased in fmr1-/- zebrafish

  2. Loss-of-function fmr1 mutants carrying an anti-fmr1 miRNA transgene show abnormal neuronal morphology and connectivity similar to that seen in human fragile X syndrome.

Mouse (Murine) Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. We show here that in mouse models PFC (show CFP ELISA Kits) dysfunction in Fragile X Syndrome (FX) can be attributed to the continued absence of FMRP from the PFC (show CFP ELISA Kits), independent of FMRP status during development.

  2. Loss of the Fragile X mental retardation protein leads to excessive excitatory compared with inhibitory inputs in neurons extracting information about sound levels. Functionally, this elevated excitation results in increased firing rates, and abnormal coding of frequency and binaural sound localization cues. Imbalanced early-stage sound level processing could partially explain the auditory processing deficits in FXS.

  3. The results of this study suggest dysregulated NMDARs in the pathophysiology of FXS leading to altered mGluR (show GRM8 ELISA Kits)-mediated Long-Term Depression.

  4. FMRP mediates structural plasticity of olfactory bulb adult-born neurons to support olfactory learning through alphaCaMKII local translation.

  5. This study demonstrated that astrocyte-specific Fmr1 conditional knock-out and restoration mice, and provided compelling evidence that the selective loss of astroglial FMRP contributes to cortical synaptic deficits in FXS.

  6. FMRP is involved in pri-miRNA processing via enhancing DROSHA (show DROSHA ELISA Kits) expression that may play an important role in fragile X syndrome.

  7. FMRP is likely to participate in retinal physiology, since its expression changes with light exposure. In addition, the expression pattern and regulation by light of FMRP seems well conserved since it was similar in both mouse and chick.

  8. Male offspring of Fmr1+/- mothers, independent of their own Fmr1 genotype, exhibit social behavior abnormality.

  9. This study demonstrated that alterations in intrinsic properties in individual neurons are involved in the abnormal excitability of cortical circuitry in Fmr-1 knockout mice.

  10. One third of the putative mRNA targets described for FMRP appear to be transported in granules and FMRP is more abundant in granules than in polyribosomes. This observation supports a primary role for FMRP in granules biology.

FMR1 Antigen Profile

Antigen Summary

The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.

Alternative names and synonyms associated with FMR1

  • CG6203 gene product from transcript CG6203-RC (Fmr1) Elisa Kit
  • fragile X mental retardation 1 (FMR1) Elisa Kit
  • fragile X mental retardation 1 (Fmr1) Elisa Kit
  • fragile X mental retardation 1 (fmr1) Elisa Kit
  • fragile X mental retardation syndrome 1 (Fmr1) Elisa Kit
  • AT24755 Elisa Kit
  • BcDNA:GM08679 Elisa Kit
  • cg6203 Elisa Kit
  • dfmr Elisa Kit
  • dfmr1 Elisa Kit
  • dFmrp Elisa Kit
  • dfxr Elisa Kit
  • dfxr1 Elisa Kit
  • dFXRP Elisa Kit
  • Dmel\\CG6203 Elisa Kit
  • dmfr1 Elisa Kit
  • EP(3)3517 Elisa Kit
  • fmr Elisa Kit
  • Fmr-1 Elisa Kit
  • fmr1 Elisa Kit
  • Fmrp Elisa Kit
  • FRAXA Elisa Kit
  • FXR Elisa Kit
  • POF Elisa Kit
  • POF1 Elisa Kit
  • zFMR1 Elisa Kit

Protein level used designations for FMR1

CG6203-PA , CG6203-PB , CG6203-PC , CG6203-PD , CG6203-PE , CG6203-PF , CG6203-PG , CG6203-PH , CG6203-PI , Fmr1-PA , Fmr1-PB , Fmr1-PC , Fmr1-PD , Fmr1-PE , Fmr1-PF , Fmr1-PG , Fmr1-PH , Fmr1-PI , Fragile-X mental retardation protein , Fragile-X-related , dFmr1 , drosophila fragile X mental retardation protein , fragile X , fragile X mental retardation , fragile X mental retardation 1 , fragile X mental retardation gene , fragile X mental retardation protein , fragile X protein , fragile X related protein , fragile X-related , fragile x related , fragile-X , fragile X mental retardation protein 1 , fragile X mental retardation protein 1 homolog , fragile X mental retardation syndrome 1 homolog , fragile X mental retardation-1 protein , protein FMR-1 , ragile X mental retardation protein , fragile X mental retardation 1 protein , FMRP , mFmr1p

37528 Drosophila melanogaster
465894 Pan troglodytes
2332 Homo sapiens
481070 Canis lupus familiaris
24948 Rattus norvegicus
259191 Danio rerio
422395 Gallus gallus
100155078 Sus scrofa
507482 Bos taurus
100172902 Pongo abelii
14265 Mus musculus
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