Browse our anti-Gremlin 1 (GREM1) Antibodies

Full name:
anti-Gremlin 1 Antibodies (GREM1)
On www.antibodies-online.com are 129 Gremlin 1 (GREM1) Antibodies from 20 different suppliers available. Additionally we are shipping Gremlin 1 Kits (43) and Gremlin 1 Proteins (34) and many more products for this protein. A total of 211 Gremlin 1 products are currently listed.
Synonyms:
cktsf1b1, DAND2, DRM, Grem, GREM1, GREMLIN, gremlin-1, IHG-2, ld, MGC136702, pig2, zgc:136702
list all antibodies Gene Name GeneID UniProt
GREM1 23892 O70326
GREM1 50566 O35793
GREM1 26585 O60565

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Top referenced anti-Gremlin 1 Antibodies

  1. Human Polyclonal GREM1 Primary Antibody for IHC (p), WB - ABIN390078 : Jara, Chacón, Burgos, Droguett, Valdivieso, Ortiz, Troncoso, Mezzano: Expression of gremlin, a bone morphogenetic protein antagonist,is associated with vascular calcification in uraemia. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009 (PubMed)
    Show all 10 references for 390078

  2. Human Polyclonal GREM1 Primary Antibody for IHC (p), IHC - ABIN252810 : Okamoto, Lezhava, Hosaka, Okamoto-Hosoya, Ochi: Enhanced expression of S-adenosylmethionine synthetase causes overproduction of actinorhodin in Streptomyces coelicolor A3(2). in Journal of bacteriology 2003 (PubMed)
    Show all 5 references for 252810

  3. Human Polyclonal GREM1 Primary Antibody for EIA, WB - ABIN952628 : Dimitrov, Voet, De Smet, Vermeesch, Devriendt, Fryns, Debeer: Genomic rearrangements of the GREM1-FMN1 locus cause oligosyndactyly, radio-ulnar synostosis, hearing loss, renal defects syndrome and Cenani--Lenz-like non-syndromic oligosyndactyly. in Journal of medical genetics 2010 (PubMed)
    Show all 5 references for 952628

  4. Human Polyclonal GREM1 Primary Antibody for IF (p), IHC (p) - ABIN687082 : Wellbrock, Sheikhzadeh, Oliveira-Ferrer, Stamm, Hillebrand, Keyser, Klokow, Vohwinkel, Bonk, Otto, Streichert, Balabanov, Hagel, Rybczynski, Bentzien, Bokemeyer, von Kodolitsch, Fiedler: Overexpression of Gremlin-1 in patients with Loeys-Dietz syndrome: implications on pathophysiology and early disease detection. in PLoS ONE 2014 (PubMed)

  5. Human Monoclonal GREM1 Primary Antibody for ELISA, WB - ABIN565294 : Sha, Zhang, Zhang, Wan, Zhao, Li, Lang: Elevated levels of gremlin-1 in eutopic endometrium and peripheral serum in patients with endometriosis. in Fertility and sterility 2009 (PubMed)

More Antibodies against Gremlin 1 Interaction Partners

Zebrafish Gremlin 1 (GREM1) interaction partners

  1. FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 (show BMP4 Antibodies) transcription, and activation of bmp antagonists, nog2 and grem1a.

  2. Results suggest that the negative regulatory loops between BMP/Tbx2 (show TBX2 Antibodies) and Gremlin or Hey1 (show HEY1 Antibodies) are responsible for defining the territory of the pronephric nephron.

  3. Gremlin encodes a maternal transcript, and the zygotic transcription is turned on at the mid-blastula transition.

Mouse (Murine) Gremlin 1 (GREM1) interaction partners

  1. Gremlin-1 protein expression was detected specifically in the lung after birth and did not result in any signs of respiratory insufficiency. CXCL10 chemokine le (show CXCL10 Antibodies)vels correlate negatively with gremlin-1 levels in mouse and human lung.

  2. Data show that parathyroid hormone-related protein (PTHrP (show PTHLH Antibodies)) regulates gremlin levels in pancreatic acinar and stellate cells.

  3. Gremlin is a key pro-fibrogenic factor in chronic pancreatitis

  4. Gremlin/VEGFR2 (show KDR Antibodies) axis participates in renal inflammation and could be a novel target for kidney disease.

  5. GREM1 induces fibrosis and angiogenesis in mouse peritoneum and is associated with increased solute transport in peritoneal dialysis patients.

  6. Grem1 expression identifies distinct connective tissue stem cells in both the bone (osteochondroreticular stem cells) and the intestine (reticular stem cells).

  7. A Gli (show GLI1 Antibodies)-dependent cis (show CISH Antibodies)-regulatory module (CRM), regulation of Grem1 in the mouse limb bud, is reported.

  8. Suggest cross-talk between angiogenesis and inflammation and demonstrate a crucial role of CREB (show CREB1 Antibodies) activation in the modulation of the VEGFR2 (show KDR Antibodies)-mediated proinflammatory/proangiogenic response of endothelial cells to gremlin.

  9. The present data disclose that Gremlin-1 is an endogenous antagonist of MIF (show MIF Antibodies) and define a role for Gremlin-1/MIF (show MIF Antibodies) interaction in atherosclerosis.

  10. endogenous Gremlin blockade inhibited TGF-beta (show TGFB1 Antibodies)-mediated matrix production and epithelial mesenchymal transition in kidney fibroblasts

Goat Gremlin 1 (GREM1) interaction partners

  1. Wattles in goats are associated with the FMN1 (show FMN1 Antibodies)/GREM1 region on chromosome 10

Human Gremlin 1 (GREM1) interaction partners

  1. In human Idiopathic Pulmonary Fibrosis patient samples the study established a strong negative correlation in the mRNA expression levels of gremlin-1 and CXCL10 (show CXCL10 Antibodies). The results suggest that in addition to regulation of epithelial-mesenchymal crosstalk during tissue injury, gremlin-1 modulates inflammatory cell recruitment and anti-fibrotic chemokine (show CCL1 Antibodies) production in the lung.

  2. The results suggest that inhibition of BMP-2 by Gremlin-1 occurs by a mechanism that is distinct from other known inhibitors such as Noggin and Chordin and study propose a novel model of BMP-2-Gremlin-1 interaction yet not seen among any BMP antagonists, and cannot rule out that several different oligomeric states could be found, depending on the concentration of the two proteins.

  3. Gremlin1 inhibited the cell viability and osteogenic differentiation of human mesenchymal stem cells (MSCs) and the suppression of gremlin1 expression can increase the cell viability and osteogenic differentiation of human MSCs induced by BMP-2 (show BMP2 Antibodies).

  4. overexpression of GREM1 in mesenchymal stem cells have greater therapeutic effects against ischemia.

  5. Diabetic patients with acute coronary syndrome show increased levels of Gremlin-1 and MIF (show AMH Antibodies), leading to unfavorable Gremlin-1/MIF (show AMH Antibodies) ratios. However, DM2 (show CNBP Antibodies) alone is not associated with low Gremlin-1/MIF (show AMH Antibodies) ratios.

  6. The critical element of the Gremlin-1 molecule for regulating MIF (show AMH Antibodies)-induced chemotactic activity lies at the C-terminal region. A single amino acid exchange of an arginine to an alanine residue is sufficient to abolish the antagonistic effect of Gremlin-1 on MIF (show AMH Antibodies). The Gremlin-1 mutant R172A failed to reduce MIF (show AMH Antibodies)-induced monocyte differentiation into macrophages.

  7. Study identified a high penetrant duplication in the regulatory region of GREM1, predisposing to colorectal cancer (CRC (show CALR Antibodies)) in a family with attenuated/ atypical polyposis. A POLE variant was also identified in a patient with early onset CRC (show CALR Antibodies).

  8. Results found that high mRNA expression level of Gremlin 1 was an independent poor prognostic factor for cervical neoplasm. it is suggested that Gremlin 1 may have a role in clinical recurrence and maintaining cancer stem cell-like properties.

  9. our data suggest that the closely located GREM1 gene contributes to a rare clinical Nonsyndromic orofacial clefts entity

  10. results might suggest that variants influencing GREM1 expression levels, rather than variants affecting the function of the encoded protein, are significant factors in NSCL (show NHLH1 Antibodies)/P etiology.

Xenopus laevis Gremlin 1 (GREM1) interaction partners

  1. both the regenerating and contralateral, developing limb of grem1 transgenics developed skeletal defects, suggesting that overexpressing grem1 negatively affects limb patterning

Gremlin 1 (GREM1) Antigen Profile

Antigen Summary

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Gremlin 1 (GREM1)

  • gremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis) (grem1a) antibody
  • gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) (GREM1) antibody
  • gremlin 1 (Grem1) antibody
  • gremlin 1 (grem1) antibody
  • gremlin 1 (GREM1) antibody
  • gremlin 1, DAN family BMP antagonist (GREM1) antibody
  • gremlin 1, DAN family BMP antagonist (Grem1) antibody
  • gremlin 1, DAN family BMP antagonist (grem1) antibody
  • gremlin-1 (LOC100342066) antibody
  • gremlin-1-like (LOC100156280) antibody
  • cktsf1b1 antibody
  • DAND2 antibody
  • DRM antibody
  • Grem antibody
  • GREM1 antibody
  • GREMLIN antibody
  • gremlin-1 antibody
  • IHG-2 antibody
  • ld antibody
  • MGC136702 antibody
  • pig2 antibody
  • zgc:136702 antibody

Protein level used designations for anti-Gremlin 1 (GREM1) Antibodies

gremlin 1 homolog a, cysteine knot superfamily , gremlin 1 homolog, cysteine knot superfamily , gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) , gremlin 1 , GLEAN_07044 , cysteine knot superfamily 1 , cysteine knot superfamily 1, BMP antagonist 1 , down-regulated in Mos-transformed cells protein , down-regulated in v-mos-transformed cells , gremlin-1 , gremlin 1, cysteine knot superfamily, homolog , Cysteine knot superfamily 1, BMP antagonist 1 , DAN domain family member 2 , cell proliferation-inducing gene 2 protein , gremlin 1-like protein , increased in high glucose-2

GENE ID SPECIES
405778 Danio rerio
467642 Pan troglodytes
662541 Tribolium castaneum
100101711 Xenopus (Silurana) tropicalis
23892 Mus musculus
50566 Rattus norvegicus
100860969 Capra hircus
487475 Canis lupus familiaris
539079 Bos taurus
395826 Gallus gallus
101102396 Ovis aries
574176 Macaca mulatta
26585 Homo sapiens
100730568 Cavia porcellus
399094 Xenopus laevis
100342066 Oryctolagus cuniculus
100156280 Sus scrofa
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