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Browse our Gremlin 1 Proteins (GREM1)

Full name:
Gremlin 1 Proteins (GREM1)
On www.antibodies-online.com are 34 Gremlin 1 (GREM1) Proteins from 13 different suppliers available. Additionally we are shipping Gremlin 1 Antibodies (129) and Gremlin 1 Kits (40) and many more products for this protein. A total of 208 Gremlin 1 products are currently listed.
Synonyms:
cktsf1b1, DAND2, DRM, Grem, GREM1, GREMLIN, gremlin-1, IHG-2, ld, MGC136702, pig2, zgc:136702
list all proteins Gene Name GeneID UniProt
GREM1 23892 O70326
GREM1 50566 O35793
GREM1 26585 O60565

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Gremlin 1 Proteins (GREM1) by Origin

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Top referenced Gremlin 1 Proteins

  1. Human GREM1 Protein expressed in CHO Cells - ABIN2666457 : Kim, Yoon, Lee, Ha, Kim, Kim, Chung: Gremlin-1 induces BMP-independent tumor cell proliferation, migration, and invasion. in PLoS ONE 2012 (PubMed)
    Show all 6 references for ABIN2666457

  2. Human GREM1 Protein expressed in Escherichia coli (E. coli) - ABIN1098774 : Stabile, Mitola, Moroni, Belleri, Nicoli, Coltrini, Peri, Pessi, Orsatti, Talamo, Castronovo, Waltregny, Cotelli, Ribatti, Presta: Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor. in Blood 2007 (PubMed)

More Proteins for Gremlin 1 Interaction Partners

Zebrafish Gremlin 1 (GREM1) interaction partners

  1. FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 (show BMP4 Proteins) transcription, and activation of bmp antagonists, nog2 and grem1a.

  2. Results suggest that the negative regulatory loops between BMP/Tbx2 (show TBX2 Proteins) and Gremlin or Hey1 (show HEY1 Proteins) are responsible for defining the territory of the pronephric nephron.

  3. Gremlin encodes a maternal transcript, and the zygotic transcription is turned on at the mid-blastula transition.

Mouse (Murine) Gremlin 1 (GREM1) interaction partners

  1. Data show that parathyroid hormone-related protein (PTHrP) regulates gremlin levels in pancreatic acinar and stellate cells.

  2. Gremlin is a key pro-fibrogenic factor in chronic pancreatitis

  3. Gremlin/VEGFR2 (show KDR Proteins) axis participates in renal inflammation and could be a novel target for kidney disease.

  4. GREM1 induces fibrosis and angiogenesis in mouse peritoneum and is associated with increased solute transport in peritoneal dialysis patients.

  5. Grem1 expression identifies distinct connective tissue stem cells in both the bone (osteochondroreticular stem cells) and the intestine (reticular stem cells).

  6. A Gli (show GLI1 Proteins)-dependent cis (show CISH Proteins)-regulatory module (CRM), regulation of Grem1 in the mouse limb bud, is reported.

  7. Suggest cross-talk between angiogenesis and inflammation and demonstrate a crucial role of CREB (show CREB1 Proteins) activation in the modulation of the VEGFR2 (show KDR Proteins)-mediated proinflammatory/proangiogenic response of endothelial cells to gremlin.

  8. The present data disclose that Gremlin-1 is an endogenous antagonist of MIF (show MIF Proteins) and define a role for Gremlin-1/MIF (show MIF Proteins) interaction in atherosclerosis.

  9. endogenous Gremlin blockade inhibited TGF-beta (show TGFB1 Proteins)-mediated matrix production and epithelial mesenchymal transition in kidney fibroblasts

  10. gremlin was clearly elevated in high glucose cultured mouse podocytes, and likely employed endogenous canonical TGFbeta1 (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling to induce podocyte injury. Knockdown gremlin1 by siRNA may be clinically useful in the attenuation of podocyte injury.

Goat Gremlin 1 (GREM1) interaction partners

  1. Wattles in goats are associated with the FMN1 (show FMN1 Proteins)/GREM1 region on chromosome 10

Human Gremlin 1 (GREM1) interaction partners

  1. Diabetic patients with acute coronary syndrome show increased levels of Gremlin-1 and MIF (show AMH Proteins), leading to unfavorable Gremlin-1/MIF (show AMH Proteins) ratios. However, DM2 (show CNBP Proteins) alone is not associated with low Gremlin-1/MIF (show AMH Proteins) ratios.

  2. The critical element of the Gremlin-1 molecule for regulating MIF (show AMH Proteins)-induced chemotactic activity lies at the C-terminal region. A single amino acid exchange of an arginine to an alanine residue is sufficient to abolish the antagonistic effect of Gremlin-1 on MIF (show AMH Proteins). The Gremlin-1 mutant R172A failed to reduce MIF (show AMH Proteins)-induced monocyte differentiation into macrophages.

  3. Study identified a high penetrant duplication in the regulatory region of GREM1, predisposing to colorectal cancer (CRC (show CALR Proteins)) in a family with attenuated/ atypical polyposis. A POLE variant was also identified in a patient with early onset CRC (show CALR Proteins).

  4. Results found that high mRNA expression level of Gremlin 1 was an independent poor prognostic factor for cervical neoplasm. it is suggested that Gremlin 1 may have a role in clinical recurrence and maintaining cancer stem cell-like properties.

  5. our data suggest that the closely located GREM1 gene contributes to a rare clinical Nonsyndromic orofacial clefts entity

  6. results might suggest that variants influencing GREM1 expression levels, rather than variants affecting the function of the encoded protein, are significant factors in NSCL (show NHLH1 Proteins)/P etiology.

  7. Gremlin is a key pro-fibrogenic factor in chronic pancreatitis

  8. Data suggest that the hereditary mixed polyposis syndrome (HMPS) 40 kb duplication upstream of the gremlin 1 protein (GREM1) gene is present at low rates in Jewish Ashkenazi individuals of a familial predisposition to colorectal cancer (CRC (show CALR Proteins)).

  9. Gremlin-1 plasma levels of Loeys-Dietz syndrome patients were significantly elevated compared to healthy control subjects.

  10. transgenic mice overexpressing Gremlin in renal tubules develop greater glomerular and tubulointerstitial injury in response to diabetic-mediated damage

Xenopus laevis Gremlin 1 (GREM1) interaction partners

  1. both the regenerating and contralateral, developing limb of grem1 transgenics developed skeletal defects, suggesting that overexpressing grem1 negatively affects limb patterning

Gremlin 1 (GREM1) Protein Profile

Protein Summary

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Gremlin 1 (GREM1)

  • gremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis) (grem1a)
  • gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) (GREM1)
  • gremlin 1 (Grem1)
  • gremlin 1 (grem1)
  • gremlin 1 (GREM1)
  • gremlin 1, DAN family BMP antagonist (GREM1)
  • gremlin 1, DAN family BMP antagonist (Grem1)
  • gremlin 1, DAN family BMP antagonist (grem1)
  • gremlin-1 (LOC100342066)
  • gremlin-1-like (LOC100156280)
  • cktsf1b1 protein
  • DAND2 protein
  • DRM protein
  • Grem protein
  • GREM1 protein
  • GREMLIN protein
  • gremlin-1 protein
  • IHG-2 protein
  • ld protein
  • MGC136702 protein
  • pig2 protein
  • zgc:136702 protein

Protein level used designations for Gremlin 1 Proteins (GREM1)

gremlin 1 homolog a, cysteine knot superfamily , gremlin 1 homolog, cysteine knot superfamily , gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) , gremlin 1 , GLEAN_07044 , cysteine knot superfamily 1 , cysteine knot superfamily 1, BMP antagonist 1 , down-regulated in Mos-transformed cells protein , down-regulated in v-mos-transformed cells , gremlin-1 , gremlin 1, cysteine knot superfamily, homolog , Cysteine knot superfamily 1, BMP antagonist 1 , DAN domain family member 2 , cell proliferation-inducing gene 2 protein , gremlin 1-like protein , increased in high glucose-2

GENE ID SPECIES
405778 Danio rerio
467642 Pan troglodytes
662541 Tribolium castaneum
100101711 Xenopus (Silurana) tropicalis
23892 Mus musculus
50566 Rattus norvegicus
100860969 Capra hircus
487475 Canis lupus familiaris
539079 Bos taurus
395826 Gallus gallus
101102396 Ovis aries
574176 Macaca mulatta
26585 Homo sapiens
100730568 Cavia porcellus
399094 Xenopus laevis
100342066 Oryctolagus cuniculus
100156280 Sus scrofa
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