Browse our Gremlin 1 Proteins (GREM1)

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Gremlin 1 Proteins (GREM1)
On are 34 Gremlin 1 (GREM1) Proteins from 13 different suppliers available. Additionally we are shipping Gremlin 1 Antibodies (129) and Gremlin 1 Kits (43) and many more products for this protein. A total of 211 Gremlin 1 products are currently listed.
cktsf1b1, DAND2, DRM, Grem, GREM1, GREMLIN, gremlin-1, IHG-2, ld, MGC136702, pig2, zgc:136702
list all proteins Gene Name GeneID UniProt
GREM1 23892 O70326
GREM1 50566 O35793
GREM1 26585 O60565

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Gremlin 1 Proteins (GREM1) by Origin

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Top referenced Gremlin 1 Proteins

  1. Human GREM1 Protein expressed in CHO Cells - ABIN2666457 : Kim, Yoon, Lee, Ha, Kim, Kim, Chung: Gremlin-1 induces BMP-independent tumor cell proliferation, migration, and invasion. in PLoS ONE 2012 (PubMed)
    Show all 6 references for 2666457

  2. Human GREM1 Protein expressed in Escherichia coli (E. coli) - ABIN1098774 : Stabile, Mitola, Moroni, Belleri, Nicoli, Coltrini, Peri, Pessi, Orsatti, Talamo, Castronovo, Waltregny, Cotelli, Ribatti, Presta: Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor. in Blood 2007 (PubMed)

More Proteins for Gremlin 1 Interaction Partners

Zebrafish Gremlin 1 (GREM1) interaction partners

  1. FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 (show BMP4 Proteins) transcription, and activation of bmp antagonists, nog2 and grem1a.

  2. Results suggest that the negative regulatory loops between BMP/Tbx2 (show TBX2 Proteins) and Gremlin or Hey1 (show HEY1 Proteins) are responsible for defining the territory of the pronephric nephron.

  3. Gremlin encodes a maternal transcript, and the zygotic transcription is turned on at the mid-blastula transition.

Mouse (Murine) Gremlin 1 (GREM1) interaction partners

  1. Grem1 expression in the tubular epithelial compartment plays a significant role in the fibrotic response to renal injury in vivo.

  2. Gremlin-1 protein expression was detected specifically in the lung after birth and did not result in any signs of respiratory insufficiency. CXCL10 chemokine le (show CXCL10 Proteins)vels correlate negatively with gremlin-1 levels in mouse and human lung.

  3. Data show that parathyroid hormone-related protein (PTHrP) regulates gremlin levels in pancreatic acinar and stellate cells.

  4. Gremlin is a key pro-fibrogenic factor in chronic pancreatitis

  5. Gremlin/VEGFR2 (show KDR Proteins) axis participates in renal inflammation and could be a novel target for kidney disease.

  6. GREM1 induces fibrosis and angiogenesis in mouse peritoneum and is associated with increased solute transport in peritoneal dialysis patients.

  7. Grem1 expression identifies distinct connective tissue stem cells in both the bone (osteochondroreticular stem cells) and the intestine (reticular stem cells).

  8. A Gli (show GLI1 Proteins)-dependent cis (show CISH Proteins)-regulatory module (CRM), regulation of Grem1 in the mouse limb bud, is reported.

  9. Suggest cross-talk between angiogenesis and inflammation and demonstrate a crucial role of CREB (show CREB1 Proteins) activation in the modulation of the VEGFR2 (show KDR Proteins)-mediated proinflammatory/proangiogenic response of endothelial cells to gremlin.

  10. The present data disclose that Gremlin-1 is an endogenous antagonist of MIF (show MIF Proteins) and define a role for Gremlin-1/MIF (show MIF Proteins) interaction in atherosclerosis.

Goat Gremlin 1 (GREM1) interaction partners

  1. Wattles in goats are associated with the FMN1 (show FMN1 Proteins)/GREM1 region on chromosome 10

Human Gremlin 1 (GREM1) interaction partners

  1. GREM1 plays an important role in the development of glioma, and it may serve as a potential target in glioma therapy.

  2. Describe a hereditary mixed polyposis syndrome in which is characterized by SCG5 (show SCG5 Proteins)-GREM1 duplication.

  3. GREM1 is frequently expressed by myofibroblasts in scars or in the stroma of basal cell carcinomas, suggesting that GREM1 expression can be a marker for activated myofibroblasts in the cancer stroma or in scar tissue.

  4. Clinical features of hereditary mixed polyposis syndrome caused by GREM1 gene duplication include extracolonic tumors, onset of polyps in adolescence, and rapid progression of some polyps to advanced adenomas.

  5. In human Idiopathic Pulmonary Fibrosis patient samples the study established a strong negative correlation in the mRNA expression levels of gremlin-1 and CXCL10 (show CXCL10 Proteins). The results suggest that in addition to regulation of epithelial-mesenchymal crosstalk during tissue injury, gremlin-1 modulates inflammatory cell recruitment and anti-fibrotic chemokine (show CCL1 Proteins) production in the lung.

  6. The results suggest that inhibition of BMP-2 by Gremlin-1 occurs by a mechanism that is distinct from other known inhibitors such as Noggin and Chordin and study propose a novel model of BMP-2-Gremlin-1 interaction yet not seen among any BMP antagonists, and cannot rule out that several different oligomeric states could be found, depending on the concentration of the two proteins.

  7. Gremlin1 inhibited the cell viability and osteogenic differentiation of human mesenchymal stem cells (MSCs) and the suppression of gremlin1 expression can increase the cell viability and osteogenic differentiation of human MSCs induced by BMP-2 (show BMP2 Proteins).

  8. overexpression of GREM1 in mesenchymal stem cells have greater therapeutic effects against ischemia.

  9. Diabetic patients with acute coronary syndrome show increased levels of Gremlin-1 and MIF (show AMH Proteins), leading to unfavorable Gremlin-1/MIF (show AMH Proteins) ratios. However, DM2 (show CNBP Proteins) alone is not associated with low Gremlin-1/MIF (show AMH Proteins) ratios.

  10. The critical element of the Gremlin-1 molecule for regulating MIF (show AMH Proteins)-induced chemotactic activity lies at the C-terminal region. A single amino acid exchange of an arginine to an alanine residue is sufficient to abolish the antagonistic effect of Gremlin-1 on MIF (show AMH Proteins). The Gremlin-1 mutant R172A failed to reduce MIF (show AMH Proteins)-induced monocyte differentiation into macrophages.

Xenopus laevis Gremlin 1 (GREM1) interaction partners

  1. both the regenerating and contralateral, developing limb of grem1 transgenics developed skeletal defects, suggesting that overexpressing grem1 negatively affects limb patterning

Gremlin 1 (GREM1) Protein Profile

Protein Summary

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Gremlin 1 (GREM1)

  • gremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis) (grem1a)
  • gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) (GREM1)
  • gremlin 1 (Grem1)
  • gremlin 1 (grem1)
  • gremlin 1 (GREM1)
  • gremlin 1, DAN family BMP antagonist (GREM1)
  • gremlin 1, DAN family BMP antagonist (Grem1)
  • gremlin 1, DAN family BMP antagonist (grem1)
  • gremlin-1 (LOC100342066)
  • gremlin-1-like (LOC100156280)
  • cktsf1b1 protein
  • DAND2 protein
  • DRM protein
  • Grem protein
  • GREM1 protein
  • GREMLIN protein
  • gremlin-1 protein
  • IHG-2 protein
  • ld protein
  • MGC136702 protein
  • pig2 protein
  • zgc:136702 protein

Protein level used designations for Gremlin 1 Proteins (GREM1)

gremlin 1 homolog a, cysteine knot superfamily , gremlin 1 homolog, cysteine knot superfamily , gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) , gremlin 1 , GLEAN_07044 , cysteine knot superfamily 1 , cysteine knot superfamily 1, BMP antagonist 1 , down-regulated in Mos-transformed cells protein , down-regulated in v-mos-transformed cells , gremlin-1 , gremlin 1, cysteine knot superfamily, homolog , Cysteine knot superfamily 1, BMP antagonist 1 , DAN domain family member 2 , cell proliferation-inducing gene 2 protein , gremlin 1-like protein , increased in high glucose-2

405778 Danio rerio
467642 Pan troglodytes
662541 Tribolium castaneum
100101711 Xenopus (Silurana) tropicalis
23892 Mus musculus
50566 Rattus norvegicus
100860969 Capra hircus
487475 Canis lupus familiaris
539079 Bos taurus
395826 Gallus gallus
101102396 Ovis aries
574176 Macaca mulatta
26585 Homo sapiens
100730568 Cavia porcellus
399094 Xenopus laevis
100342066 Oryctolagus cuniculus
100156280 Sus scrofa
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