GREM1 Protein (AA 25-184) (Fc Tag)

Catalog No. ABIN4949105

This Recombinant GREM1 protein is produced in HEK-293 Cells. There is 1 publication available.

Quick Overview for GREM1 Protein (AA 25-184) (Fc Tag) (ABIN4949105)

Target: GREM1 (Gremlin 1 (GREM1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Application: Functional Studies (Func)

Purity: >95 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 25-184

Purification tag / Conjugate: This GREM1 protein is labelled with Fc Tag.

Sequence: AA 25-184

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.2 kDa. The protein migrates as 48-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, pH 7.5 with 1 mM EDTA

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

References

Kim, Sung, Youn, Park: "Gremlin-1 activates Akt/STAT3 signaling, which increases the glycolysis rate in breast cancer cells." in: Biochemical and biophysical research communications, Vol. 533, Issue 4, pp. 1378-1384, (2020) (PubMed).

Target Details

Target: GREM1 (Gremlin 1 (GREM1))

Alternative Name: Gremlin

Background: Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.

Molecular Weight: 44.2 kDa

NCBI Accession: NP_037504

Pathways: Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location