Browse our Integrin-Linked Kinase Proteins (ILK)

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Integrin-Linked Kinase Proteins (ILK)
On are 25 Integrin-Linked Kinase (ILK) Proteins from 11 different suppliers available. Additionally we are shipping Integrin-Linked Kinase Antibodies (247) and Integrin-Linked Kinase Kits (23) and many more products for this protein. A total of 316 Integrin-Linked Kinase products are currently listed.
AA511515, CG10504, CT29478, Dmel\\CG10504, DmILK, ESTM24, ilk, ILK-1, ILK-2, l(3)78Ca, P59, p59ILK, zgc:65842
list all proteins Gene Name GeneID UniProt
ILK 16202 O55222
ILK 3611 Q13418
ILK 170922 Q99J82

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Integrin-Linked Kinase Proteins (ILK) by Origin

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Top referenced Integrin-Linked Kinase Proteins

  1. Human ILK Protein expressed in HEK-293 Cells - ABIN2723535 : Radovanac, Morgner, Schulz, Blumbach, Patterson, Geiger, Mann, Krieg, Eckes, Fässler, Wickström: Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response. in The EMBO journal 2013 (PubMed)

More Proteins for Integrin-Linked Kinase Interaction Partners

Fruit Fly (Drosophila melanogaster) Integrin-Linked Kinase (ILK) interaction partners

  1. Targeted knockdown of the integrin focal adhesion complex components beta-integrin, PINCH (show LIMS1 Proteins), and integrin-linked kinase caused formation of multinucleate epidermal cells within the Drosophila larval epidermis.

  2. PINCH (show LIMS1 Proteins) and ILK have an independent capacity to localize at muscle attachment sites in vivo.

  3. ILK functions as an essential hub in the assembly of its partner proteins at sites of integrin adhesion.

Xenopus laevis Integrin-Linked Kinase (ILK) interaction partners

Mouse (Murine) Integrin-Linked Kinase (ILK) interaction partners

  1. It was concluded that ILK depletion modifies the transcription of GLUT4 (show SLC2A4 Proteins), which results in reduced peripheral insulin (show INS Proteins) sensitivity and glucose uptake, suggesting ILK as a molecular target and a prognostic biomarker of insulin (show INS Proteins) resistance.

  2. results demonstrate that TGF-beta1 (show TGFB1 Proteins)-induced autophagy links beta-catenin (show CTNNB1 Proteins) and Smad (show SMAD1 Proteins) signaling to promote epithelial-mesenchymal transition in C1.1 cells through a novel pY654-beta-catenin (show CTNNB1 Proteins)/p-Smad2 (show SMAD2 Proteins)/ILK pathway.

  3. ILK deletion impaired the developmental profile, proliferation, and differentiation of oligodendrocyte precursor cells.

  4. Our results define ILK as a key mechanotransducer in modulating breast cancer stem-like cells development in response to tissue mechanics and oxygen tension.

  5. iNOS (show NOS2 Proteins)-derived NO plays a crucial role during atherosclerosis by regulating the endocytic-lysosomal degradation of ILK in endothelial cells.

  6. Hepatic ILK deletion has no effect on insulin (show INS Proteins) action in lean mice but sensitizes the liver to insulin (show INS Proteins) during the challenge of high fat feeding. This effect corresponds to changes in the expression and activation of key insulin (show INS Proteins) signaling pathways as well as a greater capacity for hepatic mitochondrial glucose oxidation.

  7. this study has identified a new role for Parvin (show PARVA Proteins) and alphaPix (show ARHGEF6 Proteins) downstream of the integrin-ILK signaling axis for mammary epithelial cell differentiation.

  8. Work provides a new tool for studying mouse oligodendrocyte precursor cell migration and highlights the role of integrin-linked kinase in its regulation on extracellular matrix proteins relevant to multiple sclerosis.

  9. We conclude that ILK negatively and independently of PI3K regulated MEF2C (show MEF2C Proteins) phosphorylation activity and MCK (show CKM Proteins) mRNA expression in C2C12 cells

  10. high extracellular concentration of phosphate induced senescence in cultured smooth muscle through the activation of IGF-1 (show IGF1 Proteins) receptor and ILK overexpression

Zebrafish Integrin-Linked Kinase (ILK) interaction partners

  1. Heart failure in recessive embryonic lethal zebrafish mutant main squeeze (msq) mutants is due to a mutation in the integrin-linked kinase (ilk) gene.

  2. The lost-contact mutant on chromosome 10 encodes a nonsense mutation (Y319X) associated with defective cardiomyocytes & endothelial cells that leads to severe myocardial dysfunction. There is epistatic regulation between laminin-alpha4, integrin, & Ilk.

  3. Data show that integrin-linked kinase is an essential component downstream of laminin and integrin alpha7, providing strengthening of skeletal muscle fibre adhesion with the extracellular matrix.

Human Integrin-Linked Kinase (ILK) interaction partners

  1. KRAS-E2F1-ILK-hnRNPA1 regulatory loop enables pancreatic cancer cells to promote oncogenic KRAS signaling and to interact with the tumor microenvironment to promote aggressive phenotypes.

  2. Data indicate a regulatory role for tetraspanin 8 (Tspan8 (show TSPAN8 Proteins)) in melanoma progression by modulating cell-matrix interactions through beta1 integrin - integrin-linked kinase (ILK) axis and establish Tspan8 (show TSPAN8 Proteins) as a negative regulator of ILK activity.

  3. Our results define ILK as a key mechanotransducer in modulating breast cancer stem-like cells development in response to tissue mechanics and oxygen tension.

  4. Overexpression of ILK therefore promoted the proliferation of SHG44 human glioma cells, reduced apoptosis and reduced sensitivity to TMZ via decreasing the activity of caspase3.

  5. iNOS (show NOS2 Proteins)-derived NO plays a crucial role during atherosclerosis by regulating the endocytic-lysosomal degradation of ILK in endothelial cells.

  6. Using in vitro studies, we demonstrated that ILK and PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) inhibitors suppressed the contraction of fibroblast-populated collagen lattices, inhibited fibroblast migration, and interrupted the effect of TGF-beta1 (show TGFB1 Proteins) on promoting alpha smooth muscle actin (show ACTG2 Proteins) (alpha-SMA (show SMN1 Proteins)) expression in fibroblasts.

  7. During human endometrial decidualization, ILK is essential for morphologic transformation of endometrial stromal cells through organization of the actin cytoskeleton.

  8. These data suggest a novel link between Tiam1 and RhoG/ILK /ELMO2 pathway as upstream effectors of the Rac1-mediated phagocytic process in trabecular meshwork cells.

  9. silencing of ILK attenuates the abnormal proliferation and migration of human Tenon's capsule fibroblasts induced by TGF-beta2 (show TGFB2 Proteins).

  10. findings describe a TNFalpha (show TNF Proteins)-NF-kappaB (show NFKB1 Proteins)-mediated mechanism by which ILK expression is induced in the lymph node microenvironment and propose that ILK promotes leukemogenesis by enabling CLL cells to cope with centrosomal defects acquired during malignant transformation

Cow (Bovine) Integrin-Linked Kinase (ILK) interaction partners

  1. Integrin-linked kinase (ILK, MGC129022) is an important regulator of the endothelial phenotype and vascular network formation by directing the assembly and/or maturation of alpha5beta1-competent matrix-forming adhesions.

  2. Rac1 only partially restores the spreading defects of integrin linked kinasse (ILK)-depleted cells, suggesting that an additional ILK-dependent signal is required for cell spreading.

  3. Profilin (show PFN1 Proteins)-dependent dissociation of G-actin (show ACTB Proteins)-Tbeta4 complexes simultaneously liberates actin for filament assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK) in the lamellipodia.

Integrin-Linked Kinase (ILK) Protein Profile

Protein Summary

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with Integrin-Linked Kinase (ILK)

  • Integrin linked kinase (Ilk)
  • integrin-linked kinase (ILK)
  • integrin-linked kinase (ilk)
  • integrin-linked protein kinase (CpipJ_CPIJ016644)
  • integrin-linked kinase (Bm1_20815)
  • integrin-linked protein kinase (Tsp_07213)
  • integrin-linked protein kinase (Tsp_07224)
  • integrin-linked protein kinase (Tsp_15354)
  • Integrin-linked protein kinase (ilk)
  • integrin linked kinase (Ilk)
  • integrin linked kinase (ilk)
  • integrin-linked kinase (Ilk)
  • AA511515 protein
  • CG10504 protein
  • CT29478 protein
  • Dmel\\CG10504 protein
  • DmILK protein
  • ESTM24 protein
  • ilk protein
  • ILK-1 protein
  • ILK-2 protein
  • l(3)78Ca protein
  • P59 protein
  • p59ILK protein
  • zgc:65842 protein

Protein level used designations for Integrin-Linked Kinase Proteins (ILK)

CG10504-PA , CG10504-PB , Ilk-PA , Ilk-PB , Integrin-linked kinase , integrin linked kinase , integrin-linked protein kinase , integrin-linked kinase , Integrin-linked protein kinase , integrin binding protein kinase , loc , lost-contact , main squeeze , msq , zilk , beta-integrin-linked kinase , 59 kDa serine/threonine-protein kinase , integrin-linked kinase-2

53573 Drosophila melanogaster
374018 Gallus gallus
446640 Xenopus laevis
709944 Macaca mulatta
6050160 Culex quinquefasciatus
6099066 Brugia malayi
10898169 Trichinella spiralis
10898276 Trichinella spiralis
10910217 Trichinella spiralis
100145644 Xenopus (Silurana) tropicalis
100194973 Salmo salar
16202 Mus musculus
393543 Danio rerio
100135559 Cavia porcellus
3611 Homo sapiens
170922 Rattus norvegicus
540207 Bos taurus
100173674 Pongo abelii
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